Protein Alignment ppk5 and ASIC1

DIOPT Version :9

• Sequence 1: NP_996138.2
• Gene: ppk5 / 2768987
• FlyBaseID: FBgn0053289
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: NP_064423.2
• Gene: ASIC1 / 41
• HGNCID: 100
• Length: 574
• Species: Homo sapiens
• Alignment Length: 496
• Identity: 97/496 - (19%)
• Similarity: 170/496 - (34%)
• Gaps: 163/496 - (32%)

  Fly    56 MTPID-----QIPFPTITVCNMNQAKKSKV--EHLMPGSIRYAMLQKTCYKESNFSQYMDTQHRN 113
            :|.:|     |:.||.:|:||:|:.:.|:|  ..|.......|:|       :|..:..|||..:
Human    74 VTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALL-------NNRYEIPDTQMAD 131

  Fly   114 ETFSNFILD--------------------VSEKCADLIVSCIFHQQRIPCTDIFRETFVDEGLCC 158
            |.....:.|                    ......|:::||.|..:.....| |:..|...|.|.
Human   132 EKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCSAED-FKVVFTRYGKCY 195

  Fly   159 IFNVLHPYYLYKFKSPYIRDFTSSDRFADIAVDWDPISGYPQRLPSSYYPRPGVGVGTSMGLQIV 223
            .||                    |.|           .|.| ||.:       :..||..||:|:
Human   196 TFN--------------------SGR-----------DGRP-RLKT-------MKGGTGNGLEIM 221

  Fly   224 LNGHVDDYF-----CSSTNGQ-GFKILLYNPIDQPRMKESGLPVMIGHQTSFRIIARNVEATPSI 282
            |:...|:|.     ...|:.: |.|:.:::..:.|.:.:.|..|..|.||......:.:...|..
Human   222 LDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPP 286

  Fly   283 RNIHRTKRQCIFSDEQELLFYRYYTRRNCEAECDSMFFLRLCSCIPYYLPLIYPNASVCDVFHF- 346
            ....:.     .:.:.:|.|:..|:...|..:|::.:.:..|:|...::|   .:|..|....:
Human   287 WGTCKA-----VTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMP---GDAPYCTPEQYK 343

  Fly   347 ECLNRAESQIFDLQSSQCKEFCLTS--CH--------DLIFFPDAFSTPFSQKDVKAQTNYLT-- 399
            ||.:.|    .|....:.:|:|:..  |:        .::..|.           ||...||.
Human   344 ECADPA----LDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPS-----------KASAKYLAKK 393

  Fly   400 -NFSSEYMRKNLAVVN-FFHTDNYFRSSVRTSY-------------------------------- 430
             |.|.:|:.:|:.|:: ||...||.....:.:|
Human   394 FNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGELLMTPVPFSCHGHGVAPYHPKAGC 458

  Fly   431 -----TGPTEY--------MASTGGIMSLMIGFSVIFLAEI 458
                 .||...        :...||.|.|.||.|::.:.|:
Human   459 SLLSHEGPPPQRPFPKPCCLGDIGGQMGLFIGASILTVLEL 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk5	NP_996138.2	ASC	4..460	CDD:279230	97/496 (20%)
ASIC1	NP_064423.2	ENaC	19..556	CDD:273304	97/496 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152131
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.750