DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk5 and asic4a

DIOPT Version :9

Sequence 1:	NP_996138.2	Gene:	ppk5 / 2768987	FlyBaseID:	FBgn0053289	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_999952.1	Gene:	asic4a / 407668	ZFINID:	ZDB-GENE-040513-5	Length:	539	Species:	Danio rerio

Alignment Length:	464	Identity:	98/464 - (21%)
Similarity:	172/464 - (37%)	Gaps:	101/464 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LYFAIIFALVLFVAVNLAVGIYNKWDSTPVIIGISSKMTPIDQIPFPTITVCNMNQAKKS----- 78
            |.|.:..||.|:.|...|:.....    |.:..::.:.||  ::.||.:|:||:|:.:.|
Zfish    71 LAFLVSLALFLYQAAKCAISYLEH----PHVTALNEEATP--EMVFPAVTICNINRFRFSALTDA 129

  Fly    79 KVEHLMPGSIRYAMLQKTCYKESNFSQYMDTQHRNETFSNFILDVSEKCADLIVSCIFHQQRIPC 143
            .:.||       |.|.....|..:..:..|.::......:.......:..:::.||.|..|....
Zfish   130 DIYHL-------ANLTGLPPKNKDGHKPTDLEYPAPDMQDIFNRTGHQLEEMLKSCNFSGQNCSA 187

  Fly   144 TDIFRETFVDEGLCCIFNVLHPYYLYKFKSPYIRDFTSSDRFADIAVDWDPISGYPQRLPSSYYP 208
            .| |...:...|.|..||                                     ..:..|....
Zfish   188 ED-FTVVYTRYGKCYTFN-------------------------------------GNKTTSRKTK 214

  Fly   209 RPGVGVGTSMGLQIVLNGHVDDY--FCSSTN----GQGFKILLYNPIDQPRMKESGLPVMIGHQT 267
            :.|:|    .||:|:|:...|||  ....||    ..|.::.:::..:.|.:.:.|..|..|.||
Zfish   215 QGGMG----NGLEIMLDIQQDDYLPIWKETNETSLEAGIRVQIHSQDEPPYIHQLGFGVSPGFQT 275

  Fly   268 SFRIIARNVEATPSIRNIHRTKRQCIFSDEQELLFYRYYTRRNCEAECDSMFFLRLCSCIPYYLP 332
            ......:.:...|      :....|..:.||.:..|..|:...|...|:::..||.|.|...::|
Zfish   276 FVSCQEQRLTYLP------QPWGNCRSTSEQMIPGYDTYSISACRLRCETLEVLRECKCRMVHMP 334

  Fly   333 LIYPNASVCDVFHFECLNRAESQIFDLQSSQCKEFCLTSCH--------DLIFFPDAFSTPFSQK 389
               .:|::|.....:|:::|.:.:.......|  ||.|.|:        .::..|.
Zfish   335 ---GDANICTPSDIKCVDKALALLQKSSGDTC--FCETPCNLTRYGKELSMVKIPS--------- 385

  Fly   390 DVKAQTNYLT---NFSSEYMRKNLAVVN-FFHTDNYFRSSVRTSYTGPTEYMASTGGIMSLMIGF 450
              |....||:   :.|.:|:|.|..|:: ||...||.....:.:| .....:...||.|.|.||.
Zfish   386 --KGSARYLSRKYDKSEDYIRDNFLVLDIFFEALNYETIEQKKAY-DVAGLLGDIGGQMGLFIGA 447

  Fly   451 SVIFLAEII 459
            ||:.:.||:
Zfish   448 SVLTILEIL 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk5	NP_996138.2	ASC	4..460	CDD:279230	98/464 (21%)
asic4a	NP_999952.1	ASC	44..472	CDD:295594	98/464 (21%)
asic4a	NP_999952.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	474..494
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586640
Domainoid	1	1.000	101	1.000	Domainoid score	I6864
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I4956
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.800