Protein Alignment ppk5 and ASIC2

DIOPT Version :10

• Sequence 1: NP_996138.2
• Gene: ppk5 / 2768987
• FlyBaseID: FBgn0053289
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: NP_899233.1
• Gene: ASIC2 / 40
• HGNCID: 99
• Length: 563
• Species: Homo sapiens
• Alignment Length: 507
• Identity: 109/507 - (21%)
• Similarity: 186/507 - (36%)
• Gaps: 127/507 - (25%)

  Fly    16 WIKLYFAIIFALVLFVAVNLAVGIYNKWDSTPVIIGIS-SKMTPID-----QIPFPTITVCNMNQ 74
            |: |.|...|.|:|            .|.|..::..:| ...|.:.     |:|||.:||||.|.
Human    89 WV-LAFCTSFGLLL------------SWSSNRLLYWLSFPSHTRVHREWSRQLPFPAVTVCNNNP 140

  Fly    75 AKKSKVEHLMPGSIRYA-------MLQKTC------------------YKESNFSQYMDTQHRNE 114
            .   :...|..|.:.||       :..:|.                  .|.::|..::..:|...
Human   141 L---RFPRLSKGDLYYAGHWLGLLLPNRTARPLVSELLRGDEPRRQWFRKLADFRLFLPPRHFEG 202

  Fly   115 TFSNFILDVSEKCADLIVSCIFHQQRIPC-TDIFRETFVDEGLCCIFNVLHPYYLYKFKSPYIRD 178
            ..:.|:..:..:..|:::||.:..:.  | ...|...|...|.|.:||
Human   203 ISAAFMDRLGHQLEDMLLSCKYRGEL--CGPHNFSSVFTKYGKCYMFN----------------- 248

  Fly   179 FTSSDRFADIAVDWDPISGYPQRLPSSYYPRPGVGVGTSMGLQIVLNGHVDDYFC------SSTN 237
              |.:       |..|:             ...|..||..||:|:|:...|:|..      .:|.
Human   249 --SGE-------DGKPL-------------LTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTF 291

  Fly   238 GQGFKILLYNPIDQPRMKESGLPVMIGHQTSFRIIARNVEATPSIRNIHRTKRQCIFSDEQELLF 302
            ..|.|:.:::..:.|.::|.|..|..|.||......:.:...|......|       |.|..|.|
Human   292 EAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECR-------SSEMGLDF 349

  Fly   303 YRYYTRRNCEAECDSMFFLRLCSCIPYYLPLIYPNASVC-DVFHFECLNRAESQIFDLQSSQCKE 366
            :..|:...|..:|::.:.:..|:|...::|   .:|..| ...|.||...|...:.:..|:.|
Human   350 FPVYSITACRIDCETRYIVENCNCRMVHMP---GDAPFCTPEQHKECAEPALGLLAEKDSNYC-- 409

  Fly   367 FCLTSCH--------DLIFFPDAFSTPFSQKDVKAQTNYLTNFSSEYMRKNLAVVN-FFHTDNYF 422
            .|.|.|:        .::..|...|..:.:|..        |.|.:|:.:|:.|:: ||...||.
Human   410 LCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKF--------NKSEKYISENILVLDIFFEALNYE 466

  Fly   423 RSSVRTSYTGPTEYMASTGGIMSLMIGFSVIFLAEII-YIILFVSTLLLILI 473
            ....:.:|. ....:...||.|.|.||.|::.:.|:. ||...:...||.|:
Human   467 TIEQKKAYE-VAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLL 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk5	NP_996138.2	ASC	4..460	CDD:459966	104/492 (21%)
ASIC2	NP_899233.1	ENaC	64..547	CDD:273304	109/507 (21%)