DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk5 and ppk26

DIOPT Version :9

Sequence 1:	NP_996138.2	Gene:	ppk5 / 2768987	FlyBaseID:	FBgn0053289	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_648125.3	Gene:	ppk26 / 38835	FlyBaseID:	FBgn0035785	Length:	597	Species:	Drosophila melanogaster

Alignment Length:	497	Identity:	128/497 - (25%)
Similarity:	228/497 - (45%)	Gaps:	59/497 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 KLYFAIIFALVLFVAVNLAVGIYNKWDSTPVIIGISSKMTPIDQIPFPTITVCNMNQAKKS---- 78
            :|::..:..|.:|..|.|.:.|::||::.|||:..:.|.||:.|||||.:|||...:.::.
  Fly    96 RLFWISVLVLSVFTCVKLTLNIWDKWNNNPVIVSFAEKSTPVWQIPFPAVTVCPETKTRREIFNF 160

  Fly    79 --------KVEHLMPGSIRYAMLQKTCYKESNFSQYMDTQHRNETFSN----------FILDVSE 125
                    ..:..:.|.:..:..||..|  ...||..:....:.|..|          .:.:||.
  Fly   161 TDSYHQVRDFQSNVSGIVDLSDKQKGLY--GAVSQVCEPHLHDVTLGNKTRRGMEIIDALTEVSP 223

  Fly   126 KCADLIVSCIFHQQRIPCTDIFRETFVDEGLCCIFNVLHPYYLYKFKSPYIRDFTSSDRFADIAV 190
            ...|..::|.:....:.|:|||.:...::|:|..||.|.|..:::.:. .|.||...:. ..:::
  Fly   224 HFDDTYLNCKWRNSPVKCSDIFHKFVTEDGVCFSFNSLSPAEIFRAEG-IIPDFIFREE-NRLSM 286

  Fly   191 DWDPISGYPQRLPSSYYPRPGVGVGTSMGLQIVLNG-HVD-DYFCSSTNGQGFKILLYNPIDQPR 253
            ||:...||.....:|.||...:|.|...||.:.:.| .:| |..|... .|||||||:.|.|..:
  Fly   287 DWNVEDGYSASADTSPYPNRVLGPGARAGLYLFMGGAEIDFDDMCRGP-VQGFKILLHTPGDVAQ 350

  Fly   254 MKESGLPVMIGHQTSFRIIARNVEATPSIRNIHRTKRQCIFSDEQELLFYRYYTRRNCEAECDSM 318
            :.:....:....:....|..:.:..:..:::....:|||.|..|:||.::..|::.|||.||.:.
  Fly   351 VSKQYFRIPFDQEVLISIRPKIITTSDGLKHYEPNRRQCYFQKERELRYFNIYSQSNCELECLAN 415

  Fly   319 FFLRLCSCIPYYLPLIYPNASVCDVFHFECLNRAESQIFDLQSSQ--------------CKEFCL 369
            |.|..|.|:.:.:|. ..|..||.....:|.|:||.::...:.:|              |.  ||
  Fly   416 FTLTKCGCVKFSMPR-NVNMPVCGDASLKCYNQAEDELLLREFTQGLVNAGENTRGETECN--CL 477

  Fly   370 TSCHDLIFFPDAFSTPFSQKDVKAQTNYLTNF------SSEYMRKNLAVVNFFHTDNYFRSSVRT 428
            .||..:     |:....||.|...:|...|:.      .|:.....::.|:.|..:..|.:|.|:
  Fly   478 PSCTSI-----AYEAEISQADFDYKTVINTDSPEGKEEQSKRQGMKMSRVSIFFKEAQFLTSRRS 537

  Fly   429 SYTGPTEYMASTGGIMSLMIGFSVIFLAEIIYI--ILFVSTL 468
            ...|.|:::|:.||::.|.:|.|::.:.|:||.  :..:|.|
  Fly   538 ELYGTTDFLANCGGLLGLFMGVSMLSIVELIYFCTVRLISNL 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk5	NP_996138.2	ASC	4..460	CDD:279230	124/485 (26%)
ppk26	NP_648125.3	ASC	74..570	CDD:279230	125/486 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456759
Domainoid	1	1.000	101	1.000	Domainoid score	I6864
eggNOG	1	0.900	-	-		E1_KOG4294
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I4956
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D112386at6656
OrthoFinder	1	1.000	-	-		FOG0000867
OrthoInspector	1	1.000	-	-		mtm8412
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
	10	9.900