DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk5 and Scnn1g

DIOPT Version :9

Sequence 1:	NP_996138.2	Gene:	ppk5 / 2768987	FlyBaseID:	FBgn0053289	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_058742.2	Gene:	Scnn1g / 24768	RGDID:	3641	Length:	650	Species:	Rattus norvegicus

Alignment Length:	583	Identity:	104/583 - (17%)
Similarity:	190/583 - (32%)	Gaps:	206/583 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 WIKLYFAIIFALVLFVAVNLAVGIYNKWDSTPVIIGISSKMTPIDQIPFPTITVCNMNQAKKSKV 80
            ||......: ||:::....|....|.        :.:|.|: ...::.||.:|:||:|..|.|.|
  Rat    56 WIAFTLTAV-ALIIWQCALLVFSFYT--------VSVSIKV-HFQKLDFPAVTICNINPYKYSAV 110

  Fly    81 EHL-----------------------------MPGSIR------YAMLQKTCYKESNFSQYMD-- 108
            ..|                             ||.::.      :.::....:.|:...:..|
  Rat   111 SDLLTDLDSETKQALLSLYGVKESRKRREAGSMPSTLEGTPPRFFKLIPLLVFNENEKGKARDFF 175

  Fly   109 -----------------TQHRNE--------------------TFSNFI---------------- 120
                             ..|.:|                    |||:.|
  Rat   176 TGRKRKISGKIIHKASNVMHVHESKKLVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMA 240

  Fly   121 -------LDVSEKCADLIVSCIFHQQRIPCTDIFRETFVDEGLCC------IFNVLHPYY--LYK 170
                   :::|....:|:|:|.|                 :|:.|      :|:  ||.|  .|.
  Rat   241 QVPLEKKINMSYSAKELLVTCFF-----------------DGMSCDARNFTLFH--HPMYGNCYT 286

  Fly   171 FKSPYIRDFTSSDRFADIAVDWDPISGYPQRLPSSYYPRPGVGVGTSMGLQIVLNGHVDDYFCSS 235
            |.:.......|:                            .:| |:..|||::|..:.|:|....
  Rat   287 FNNKENATILST----------------------------SMG-GSEYGLQVILYINEDEYNPFL 322

  Fly   236 TNGQGFKILLYNPIDQPRMKESGLPVMIGHQTSFRIIARNVEATPSIRNIHRTKRQCIFSDEQEL 300
            .:..|.|:|::...:.|.:::.|:.:.....||.     .:..|.|.: :.....||. .|..::
  Rat   323 VSSTGAKVLIHQQNEYPFIEDVGMEIETAMSTSI-----GMHLTESFK-LSEPYSQCT-EDGSDV 380

  Fly   301 ----LFYRYYTRRNCEAECDSMFFLRLCSCIPYYLPL----------IYPNASVCDVFHFECLNR 351
                ::...|:.:.|...|.....:..|.|..|..||          .:||...|   :::..
  Rat   381 PVTNIYNAAYSLQICLYSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQHPNWMYC---YYQLY-- 440

  Fly   352 AESQIFDLQSSQCKEFCLTSCHDLIFFPDAFSTPFSQKDVKAQTNYLTNF----SSEYMRK---- 408
               |.|..:...|:..|..||.   |.....:|..:|...:|...:|.|.    .|:.:.|
  Rat   441 ---QAFVREELGCQSVCKQSCS---FKEWTLTTSLAQWPSEASEKWLLNVLTWDQSQQINKKLNK 499

  Fly   409 -NLAVVNFFHTDNYFRSSVRTSYTGPTEYMASTGGIMSLMIGFSVIFLAEII--YIILFVSTL 468
             :||.:..|:.|...||.:.:........:::.||.:.|.:..||:.:.|||  :.|.|.|.:
  Rat   500 TDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFIDFFSII 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk5	NP_996138.2	ASC	4..460	CDD:279230	101/573 (18%)
Scnn1g	NP_058742.2	ENaC	24..631	CDD:273304	104/583 (18%)
Scnn1g	NP_058742.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..628
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345668
Domainoid	1	1.000	111	1.000	Domainoid score	I6095
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	111	1.000	Inparanoid score	I4773
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.700