DRSC/TRiP Functional Genomics Resources

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Protein Alignment ppk5 and Scnn1b

DIOPT Version :10

Sequence 1:NP_996138.2 Gene:ppk5 / 2768987 FlyBaseID:FBgn0053289 Length:474 Species:Drosophila melanogaster
Sequence 2:NP_036780.1 Gene:Scnn1b / 24767 RGDID:3640 Length:638 Species:Rattus norvegicus


Alignment Length:581 Identity:116/581 - (19%)
Similarity:203/581 - (34%) Gaps:202/581 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 WWIKLYFAIIFALVLFVAVNLAVGIYNKWDSTPVIIGISSKMTPIDQIPFPTITVCNMNQAKKSK 79
            |::   ..::||.::.....:.:..|..|:     :.:|..| ....:.||.:||||.:..:.||
  Rat    52 WFL---LTLLFACLVCWQWGVFIQTYLSWE-----VSVSLSM-GFKTMNFPAVTVCNSSPFQYSK 107

  Fly    80 VEHLMPG--SIRYAMLQKTCYKES---------NFSQYMDT-----QHRNE-------------- 114
            |:||:..  .:..|:|.|....:|         ||:.:..|     ..||.              
  Rat   108 VKHLLKDLYKLMEAVLDKILAPKSSHTNTTSTLNFTIWNHTPLVLIDERNPDHPVVLNLFGDSHN 172

  Fly   115 -----------------------------TFSNF-----------ILDVSEKCAD---------- 129
                                         ||.||           ||..:...:.          
  Rat   173 SSNPAPGSTCNAQGCKVAMRLCSANGTVCTFRNFTSATQAVTEWYILQATNIFSQVLPQDLVGMG 237

  Fly   130 -----LIVSCIFHQQRIPC-----TDIFRETFVDEGLCCIFNVLHPYYLYKFKSPYIRDFTSSDR 184
                 :|::|:|..:  ||     |.||   :.|.|.|.|||                       
  Rat   238 YAPDRIILACLFGTE--PCSHRNFTPIF---YPDYGNCYIFN----------------------- 274

  Fly   185 FADIAVDWDPISGYPQR-LPSSYYPRPGVGVGTSMGLQIVLNGHVDDY--FCSSTNGQGFKILLY 246
                   |    |..:: |||:       ..||..||:::|:...:||  |.:||  .|.:::|:
  Rat   275 -------W----GMTEKALPSA-------NPGTEFGLKLILDIGQEDYVPFLAST--AGARLMLH 319

  Fly   247 NPIDQPRMKESGLPVMIGHQTSFRIIARNVEA-----TPSIRNIHRTKRQCIFSDEQELLFYRYY 306
            .....|.::|.|:..|.|.:||..::...::.     :|...|......|.::||     :...|
  Rat   320 EQRTYPFIREEGIYAMAGTETSIGVLLDKLQGKGEPYSPCTMNGSDVAIQNLYSD-----YNTTY 379

  Fly   307 TRRNCEAECDSMFFLRLCSCIPYYLPL----------IYPNASVCDVFHFECLNRAESQIFDLQS 361
            :.:.|...|.....:..|||..|..||          .:|:.:.|.:         ..|:..:|.
  Rat   380 SIQACLHSCFQDHMIHNCSCGHYLYPLPAGEKYCNNRDFPDWAYCYL---------SLQMSVVQR 435

  Fly   362 SQCKEFCLTSCHDLIF--------FPDAFSTPFSQKDVKAQTNYLTNFSSEYMRKNLAVVN-FFH 417
            ..|...|..||:|..:        :|...|..:....:..:.:..:|.:  ..||.:..:| :|.
  Rat   436 ETCLSMCKESCNDTQYKMTISMADWPSEASEDWILHVLSQERDQSSNIT--LSRKGIVKLNIYFQ 498

  Fly   418 TDNYFRSSVRTSYTGPTE----YMASTGGIMSLMIGFSVIFL---AEIIYIILFVSTLLLI 471
            ..||     ||....|..    .:::.||.....:|.||:.|   .|||...::::.:.|:
  Rat   499 EFNY-----RTIEESPANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIIIDFIWITVIKLV 554

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ppk5NP_996138.2 ASC 4..460 CDD:459966 114/568 (20%)
Scnn1bNP_036780.1 ENaC 21..621 CDD:273304 116/581 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 598..620
PY motif, recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L. /evidence=ECO:0000269|PubMed:12654927, ECO:0000269|PubMed:8665844 614..618
Blue background indicates that the domain is not in the aligned region.

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