Protein Alignment ppk5 and Asic4

DIOPT Version :10

• Sequence 1: NP_996138.2
• Gene: ppk5 / 2768987
• FlyBaseID: FBgn0053289
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: XP_036020902.1
• Gene: Asic4 / 241118
• MGIID: 2652846
• Length: 586
• Species: Mus musculus
• Alignment Length: 522
• Identity: 102/522 - (19%)
• Similarity: 176/522 - (33%)
• Gaps: 145/522 - (27%)

  Fly    15 WWIKLYFAIIFALVLFVAVNLAVGIYNKWDSTPVIIGISSKMTPIDQIP---FPTITVCNMNQAK 76
            |.:.|..::  |..|:.|.:||.|...:    |.::.    |.|....|   ||.:|:||:|:.:
Mouse    70 WALALLTSL--AAFLYQAASLARGYLTR----PHLVA----MDPAAPAPVAGFPAVTLCNINRFR 124

  Fly    77 KSKVE-----HLMPGSIRYAMLQKTCYKESNFSQYMDTQHRNETFSNFILDVSEKCADLIVSCIF 136
            .|.:.     ||       |.|.....|:.:..:....::......:.:.....:.||::.||.|
Mouse   125 HSALSDADIFHL-------ANLTGLPPKDRDGHRAAGLRYPEPDMVDILNRTGHQLADMLKSCNF 182

  Fly   137 HQQRIPCTDIFRETFVDEGLCCIFNVLHPYYLYKFKSPYIRDFTSSDRFADIAVDWDPISGYPQR 201
            .......:: |...:...|.|..||.                              ||.|..|.|
Mouse   183 SGHHCSASN-FSVVYTRYGKCYTFNA------------------------------DPQSSLPSR 216

  Fly   202 LPSSYYPRPGVGVGTSMGLQIVLNGHVDDY--FCSSTN----GQGFKILLYNPIDQPRMKESGLP 260
                     ..|:|:  ||:|:|:...::|  ....||    ..|.::.:::..:.|.:.:.|..
Mouse   217 ---------AGGMGS--GLEIMLDIQQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFG 270

  Fly   261 VMIGHQTSFRIIARNVEATPSIRNIHRTKRQCIFSDEQELLFYRYYTRRNCEAECDSMFFLRLCS 325
            |..|.||......:.:...|......|.:.:.   .|.||..|..|:...|...|:....|:.|.
Mouse   271 VSPGFQTFVSCQEQRLTYLPQPWGNCRAESEL---REPELQGYSAYSVSACRLRCEKEAVLQRCH 332

  Fly   326 CIPYYLP-----------------------------LIYP---------------NASVCDV-FH 345
            |...::|                             .||.               |.::|.. .:
Mouse   333 CRMVHMPGGHLQPVFGATLLSSRTSRRQRCMRTTCTRIYTHERVLMCMSGYLHMGNETICPPNIY 397

  Fly   346 FECLNRAESQIFDLQSSQCKEFCLTSCH--------DLIFFPDAFSTPFSQKDVKAQTNYLT--- 399
            .||.:.....:.......|  ||.|.|:        .::..|:           :....||.
Mouse   398 IECADHTLDSLGGGSEGPC--FCPTPCNLTRYGKEISMVKIPN-----------RGSARYLARKY 449

  Fly   400 NFSSEYMRKNLAVVNFFHTDNYFRSSVRTSYTGPTEYMASTGGIMSLMIGFSVIFLAEIIYIILF 464
            |.:..|:|:|..|::.|.......:..:.:..|.:..:...||.|.|.||.|::.|.||:..|..
Mouse   450 NRNETYIRENFLVLDVFFEALTSEAMEQQAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYE 514

  Fly   465 VS 466
            ||
Mouse   515 VS 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk5	NP_996138.2	ASC	4..460	CDD:459966	99/514 (19%)
Asic4	XP_036020902.1	ENaC	40..535	CDD:273304	102/522 (20%)