DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk5 and Scnn1g

DIOPT Version :9

Sequence 1:	NP_996138.2	Gene:	ppk5 / 2768987	FlyBaseID:	FBgn0053289	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_035456.1	Gene:	Scnn1g / 20278	MGIID:	104695	Length:	655	Species:	Mus musculus

Alignment Length:	588	Identity:	106/588 - (18%)
Similarity:	190/588 - (32%)	Gaps:	211/588 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 WIKLYFAIIFALVLFVAVNLAVGIYNKWDSTPVIIGISSKMTPIDQIPFPTITVCNMNQAKKSKV 80
            ||......: ||:::....|....|.        :.:|.|: ...::.||.:|:||:|..|.|.|
Mouse    56 WIAFTLTAV-ALIIWQCALLVFSFYT--------VSVSIKV-HFQKLDFPAVTICNINPYKYSAV 110

  Fly    81 EHLM------------------------------PGSIRYA------------------------ 91
            ..|:                              .||:|..
Mouse   111 SDLLTDLDSETKQALLSLYGVKDVLDSTPRKRREAGSMRSTWEGTPPRFLNLIPLLVFNENEKGK 175

  Fly    92 -----------MLQKTCYKESNFSQYMDTQH-------RNE-------TFSNFI----------- 120
                       :..|..:|.||.....:::.       .|:       |||:.|
Mouse   176 ARDFFTGRKRKISGKIIHKASNVMHVHESKKLVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHY 240

  Fly   121 ------------LDVSEKCADLIVSCIFHQQRIPCTDIFRETFVDEGLCC------IFNVLHPYY 167
                        :::|....:|:|:|.|                 :|:.|      :|:  ||.|
Mouse   241 MNIMAQVPLEKKINMSYSAEELLVTCFF-----------------DGMSCDARNFTLFH--HPMY 286

  Fly   168 --LYKFKSPYIRDFTSSDRFADIAVDWDPISGYPQRLPSSYYPRPGVGVGTSMGLQIVLNGHVDD 230
              .|.|.:.......|:                            .:| |:..|||::|..:.|:
Mouse   287 GNCYTFNNRENATILST----------------------------SMG-GSEYGLQVILYINEDE 322

  Fly   231 YFCSSTNGQGFKILLYNPIDQPRMKESGLPVMIGHQTSFRIIARNVEATPSIRNIHRTKRQCIFS 295
            |.....:..|.|:|::...:.|.:::.|..:.....||.     .:..|.|.: :.....||. .
Mouse   323 YNPFLVSSTGAKVLVHQQNEYPFIEDVGTEIETAMSTSI-----GMHLTESFK-LSEPYSQCT-E 380

  Fly   296 DEQEL----LFYRYYTRRNCEAECDSMFFLRLCSCIPYYLPL----------IYPNASVCDVFHF 346
            |..::    ::...|:.:.|...|.....:..|.|..|..||          .:||...|   ::
Mouse   381 DGSDVPVTNIYNAAYSLQICLYSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQHPNWMYC---YY 442

  Fly   347 ECLNRAESQIFDLQSSQCKEFCLTSCHDLIFFPDAFSTPFSQKDVKAQTNYLTNF----SSEYMR 407
            :..     |.|..:...|:..|..||.   |.....:|..:|...:|...:|.|.    .|:.:.
Mouse   443 QLY-----QAFVREELGCQSVCKQSCS---FKEWTLTTSLAQWPSEASEKWLLNVLTWDQSQQIN 499

  Fly   408 K-----NLAVVNFFHTDNYFRSSVRTSYTGPTEYMASTGGIMSLMIGFSVIFLAEII--YIILFV 465
            |     :||.:..|:.|...||.:.:........:::.||.:.|.:..||:.:.|||  :.|.|.
Mouse   500 KKLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFIDFF 564

  Fly   466 STL 468
            |.:
Mouse   565 SII 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk5	NP_996138.2	ASC	4..460	CDD:279230	103/578 (18%)
Scnn1g	NP_035456.1	ENaC	24..636	CDD:273304	106/588 (18%)
		deg-1	32..557	CDD:273309	102/576 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	582..636
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842238
Domainoid	1	1.000	108	1.000	Domainoid score	I6420
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8693
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.650