DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk5 and Scnn1b

DIOPT Version :9

Sequence 1:	NP_996138.2	Gene:	ppk5 / 2768987	FlyBaseID:	FBgn0053289	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001258952.1	Gene:	Scnn1b / 20277	MGIID:	104696	Length:	638	Species:	Mus musculus

Alignment Length:	557	Identity:	116/557 - (20%)
Similarity:	208/557 - (37%)	Gaps:	154/557 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 WWIKLYFAIIFALVLFVAVNLAVGIYNKWDSTPVIIGISSKMTPIDQIPFPTITVCNMNQAKKSK 79
            |::   ..::||.::.....:.:..|..|:     :.:|..| ....:.||.:||||.:..:.||
Mouse    52 WFL---LTLLFACLVCWQWGVFIQTYLSWE-----VSVSLSM-GFKTMNFPAVTVCNSSPFQYSK 107

  Fly    80 VEHLMP--GSIRYAMLQKTCYKESNFSQYMDTQHRNETFSNF--ILDVSEKCAD-LIVSCIF--- 136
            |:||:.  ..:..|:|:|....|::.|.  .|:..|.|..|.  ::.:.|:..| .:|..:|
Mouse   108 VKHLLKDLDELMEAVLEKILAPEASHSN--TTRTLNFTIWNHTPLVLIDERNPDHPVVLNLFGDS 170

  Fly   137 HQQRIP----------CTDIFRETFVDEGLCCIFNVLHPYYLYKFKSPYIRDFTSSDRFADIAVD 191
            |....|          |....|....:..:|.                 :|:|||:   .....:
Mouse   171 HNSSNPAPGSTCNAQGCKVAMRLCSANGTVCT-----------------LRNFTSA---TQAVTE 215

  Fly   192 W---------------DPIS-GY-PQRL---------PSS-------YYP--------------- 208
            |               |.:. || |.|:         |.|       :||
Mouse   216 WYILQATNIFSQVLPQDLVGMGYAPDRIILACLFGTEPCSHRNFTPIFYPDYGNCYIFNWGMTEE 280

  Fly   209 -RPGVGVGTSMGLQIVLNGHVDDY--FCSSTNGQGFKILLYNPIDQPRMKESGLPVMIGHQTSFR 270
             .|....||..||:::|:...:||  |.:||  .|.:::|:.....|.::|.|:..|.|.:||..
Mouse   281 TLPSANPGTEFGLKLILDIGQEDYVPFLAST--AGARLMLHEQRTYPFIREEGIYAMAGTETSIG 343

  Fly   271 IIARNVEA-----TPSIRNIHRTKRQCIFSDEQELLFYRYYTRRNCEAECDSMFFLRLCSCIPYY 330
            ::...::.     :|...|......:.::|     ::...|:.:.|...|.....:|.|||..|.
Mouse   344 VLVDKLQRKGEPYSPCTMNGSDVAIKNLYS-----VYNTTYSIQACLHSCFQDHMIRNCSCGHYL 403

  Fly   331 LPL----------IYPNASVCDVFHFECLNRAESQIFDLQSSQCKEFCLTSCHDLIF-------- 377
            .||          .:|:.:.|      .||   .|:...|...|...|..||:|..:
Mouse   404 YPLPEGEKYCNNRDFPDWAYC------YLN---LQMSVTQRETCLSMCKESCNDTQYKMTISMAD 459

  Fly   378 FPDAFSTPFSQKDVKAQTNYLTNFSSEYMRKNLAVVN-FFHTDNYFRSSVRTSYTGPTE----YM 437
            :|...|..:....:..:.:..:|.:  ..||.:..:| :|...||     ||....|..    .:
Mouse   460 WPSEASEDWILHVLSQERDQSSNIT--LSRKGIVKLNIYFQEFNY-----RTIEESPANNIVWLL 517

  Fly   438 ASTGGIMSLMIGFSVIFL---AEIIYIILFVSTLLLI 471
            ::.||.....:|.||:.|   .|||...::::.:.|:
Mouse   518 SNLGGQFGFWMGGSVLCLIEFGEIIIDFIWITIIKLV 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk5	NP_996138.2	ASC	4..460	CDD:279230	114/544 (21%)
Scnn1b	NP_001258952.1	ENaC	21..621	CDD:273304	116/557 (21%)
		deg-1	29..538	CDD:273309	112/539 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	594..620
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842214
Domainoid	1	1.000	108	1.000	Domainoid score	I6420
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I5146
Isobase	1	0.950	-	0	Normalized mean entropy	S7632
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8693
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.650