DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ppk5 and Scnn1a

DIOPT Version :10

Sequence 1:NP_996138.2 Gene:ppk5 / 2768987 FlyBaseID:FBgn0053289 Length:474 Species:Drosophila melanogaster
Sequence 2:NP_035454.3 Gene:Scnn1a / 20276 MGIID:101782 Length:699 Species:Mus musculus


Alignment Length:601 Identity:110/601 - (18%)
Similarity:197/601 - (32%) Gaps:218/601 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 LKYVISDNN---YSWWIKLYFAII------FALVLFVAVNLAVGIYNKWDSTPVIIGISSKMTPI 59
            ::.|.|.:|   .::|..|:....      |||           ::.::.|.||.:.|:...   
Mouse    97 IRLVCSKHNRMKTAFWAVLWLCTFGMMYWQFAL-----------LFEEYFSYPVSLNINLNS--- 147

  Fly    60 DQIPFPTITVCNMNQAK----KSKVEHL------------------------------------- 83
            |::.||.:|||.:|..:    |..:|.|                                     
Mouse   148 DKLVFPAVTVCTLNPYRYTEIKEDLEELDRITEQTLFDLYKYNSSYTRQAGGRRRSTRDLRGALP 212

  Fly    84 ----------MPGSIRYAMLQKTCYKESN---------FSQYMDTQHRN----ETFSNFILDV-- 123
                      .|...|.|....:..:::|         ....:..|:::    :|:|:.:..|  
Mouse   213 HPLQRLRTPPPPNPARSARSASSSVRDNNPQVDRKDWKIGFQLCNQNKSDCFYQTYSSGVDAVRE 277

  Fly   124 ---------------------SEKCADLIVSCIFHQQRIPCTDIFRETFVDEGLCCIFNVLHPYY 167
                                 .|.....|.:|.|:|  .||.......|           .||.|
Mouse   278 WYRFHYINILSRLPDTSPALEEEALGSFIFTCRFNQ--APCNQANYSQF-----------HHPMY 329

  Fly   168 --LYKFKSPYIRDFTSSDRFADIAVDWDPISGYPQRLPSSYYPRPGVGVGTSMGLQIVLNGHVDD 230
              .|.|.:....:.            |  :|..|               |.:.||.:.|....:|
Mouse   330 GNCYTFNNKNNSNL------------W--MSSMP---------------GVNNGLSLTLRTEQND 365

  Fly   231 YFCSSTNGQGFKILLYNPIDQPRMKESGLPVMIGHQTSFRIIARNVEATPS-------------- 281
            :....:...|.:::::...:...|.:.|..|..|.:||   |:...||..|              
Mouse   366 FIPLLSTVTGARVMVHGQDEPAFMDDGGFNVRPGVETS---ISMRKEALDSLGGNYGDCTENGSD 427

  Fly   282 --IRNIHRTKRQCIFSDEQELLFYRYYTRRNCEAECDSMFFLRLCSCIPYYLPLIYP---NASVC 341
              ::|::.:|                ||::.|...|.....::.|.|.  |  :.||   ....|
Mouse   428 VPVKNLYPSK----------------YTQQVCIHSCFQENMIKKCGCA--Y--IFYPKPKGVEFC 472

  Fly   342 DVFHFE----CLNRAESQIFDLQS----SQCKEFCLTSCHDLIF----FPDAFSTPFSQKDVKAQ 394
            |.....    |..:.:: .|.|.|    |:|::.|..:.:.|..    :|...|..:..:.:..|
Mouse   473 DYLKQSSWGYCYYKLQA-AFSLDSLGCFSKCRKPCSVTNYKLSAGYSRWPSVKSQDWIFEMLSLQ 536

  Fly   395 TNYLTNFSSEYMRKNLAVVN-FFHTDNYFRSSVRTSYTGPTEYMASTGGIMSLMIG---FSVIFL 455
            .||..|    ..|..:|.:| ||...||..:|...|.| ....:::.|...||..|   .||:.:
Mouse   537 NNYTIN----NKRNGVAKLNIFFKELNYKTNSESPSVT-MVSLLSNLGSQWSLWFGSSVLSVVEM 596

  Fly   456 AEIIYIILFVSTLLLI 471
            ||:|:.:|.::.::|:
Mouse   597 AELIFDLLVITLIMLL 612

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ppk5NP_996138.2 ASC 4..460 CDD:459966 107/588 (18%)
Scnn1aNP_035454.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..71
ENaC 79..676 CDD:273304 110/601 (18%)
Gating release of inhibition by proteolysis (GRIP), protease-sensitive region that is responsible for the proteolytic activation of the channel. /evidence=ECO:0000305|PubMed:18650438 200..270 6/69 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 211..244 4/32 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 637..699
PY motif, recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L. /evidence=ECO:0000250|UniProtKB:P37088 669..673
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.