DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk5 and asic-2

DIOPT Version :9

Sequence 1:	NP_996138.2	Gene:	ppk5 / 2768987	FlyBaseID:	FBgn0053289	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_492099.1	Gene:	asic-2 / 189058	WormBaseID:	WBGene00012137	Length:	545	Species:	Caenorhabditis elegans

Alignment Length:	534	Identity:	115/534 - (21%)
Similarity:	193/534 - (36%)	Gaps:	151/534 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MLKYVISDNN---YSWWIKLYFAII--FALVLFVAVNLAVGIYNKWDSTPVIIGISSKMTPIDQI 62
            ::.:|.:.||   ..:||.::..::  ||..|::.:       .|:.|.|..  :::::....||
Worm    21 VVPHVANANNKISRIFWIAIFLFVLGMFAYELYILI-------AKFFSYPAT--VNTEILFEKQI 76

  Fly    63 PFPTITVCNMNQAKKSKVE-HLMPGSIRYAMLQKTCYKES---NFSQ-----YMDTQHRNETF-- 116
             ||.:||||||..|.|.|: :....|:...|   |.|.::   .||.     |.|   .:||:
Worm    77 -FPVVTVCNMNPYKYSVVKSNSAFSSVNTLM---TTYSDATVGTFSTDKWGLYAD---NDETYDL 134

  Fly   117 -----------SNFILDVSE-----KCADLIVSCIFHQQRIPCTDIFRETFVDE--GLCCIFNVL 163
                       :|.|.|.::     ..||||..|.|  ..|||::.....|:|.  |.|..||
Worm   135 DSRAADALVLEANLISDTAKVPALYTYADLIQDCSF--AGIPCSESDFTKFIDPVYGACYSFN-- 195

  Fly   164 HPYYLYKFKSPYIRDFTSSDRFADIAVDWDPISGYPQRLPSSYYPRPGVGVGTSMGL---QIVLN 225
                                  .|.::::.             ..|.|:..|..:.|   |...|
Worm   196 ----------------------EDASLNYS-------------VSREGIQFGLKLMLTVTQTKTN 225

  Fly   226 GHVDDYFCSSTNGQGFKILLYNPIDQPRMKESGLPVMIGHQTSFRI-IARNVEATPSIRNIHRTK 289
            |:.|.  ..:|...|.:|.:.:....|.:..:|:...:|::::..: :.:||.|       .:..
Worm   226 GNTDS--LPTTKLAGARIGVNSRGSSPGLDSNGIDAGVGYESAVSVSLTQNVRA-------KKPY 281

  Fly   290 RQCIFSDEQELLFYR--YYTRRNCEAECDSMFFLRLCSCIPYYLPLIYPNASVCDVF--HFECLN 350
            ..|:..:.....:|:  .||...|...|.....:..|.|....|.| ....:.|...  ..:||.
Worm   282 GTCVDREPDSSDYYKDFIYTLETCFNGCKQRDTIAKCQCANPRLAL-GSTDTACQPIKADLDCLQ 345

  Fly   351 RAESQIFDLQSSQ---------------CKEFCLTSCHDLIFFPDAFSTPF-----SQKDVKAQT 395
            ..:..    |:|.               |.|...|....|..||   ||.:     |...|.:.:
Worm   346 TLKGN----QTSSTPNIDLLVECNCNPPCDESTYTPTVSLAQFP---STSYYVATSSTAGVGSCS 403

  Fly   396 NYLTNFSSE------YMRKNLAVVNFFHTDNYFRSSVRTSYTGPTEYMAST-----GGIMSLMIG 449
            :..:.|||:      |....:.:..|..|.:|      ..||....|..|.     ||...|.:|
Worm   404 STNSKFSSKSDCQKWYNNNGMIIQVFLETLSY------ELYTETAGYTVSNVINDLGGQAGLWLG 462

  Fly   450 FSVIFLAEIIYIIL 463
            .|||.:.|:..::|
Worm   463 LSVISVVEMTGLML 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk5	NP_996138.2	ASC	4..460	CDD:279230	114/528 (22%)
asic-2	NP_492099.1	deg-1	12..474	CDD:273309	114/530 (22%)
asic-2	NP_492099.1	ASC	13..471	CDD:279230	113/527 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I4100
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28677
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.730