Protein Alignment CG33287 and DNAI7

DIOPT Version :10

• Sequence 1: NP_001137993.1
• Gene: CG33287 / 2768986
• FlyBaseID: FBgn0053287
• Length: 1101
• Species: Drosophila melanogaster
• Sequence 2: XP_005253463.1
• Gene: DNAI7 / 55259
• HGNCID: 29599
• Length: 780
• Species: Homo sapiens
• Alignment Length: 789
• Identity: 142/789 - (17%)
• Similarity: 272/789 - (34%)
• Gaps: 204/789 - (25%)

  Fly   435 TQFEKFNIVLHEDGRVLKVIPQVVAKQDNRKSRLTEYTRM------TLGTSQMKLSEEELPFFVV 493
            |:.|:..::..|:.|.||...:...|.:..:....|..|:      .|....::...|||....:
Human    74 TKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLERRNEELEELYL 138

  Fly   494 TVQLPPH----------LCRWGKPEVCHYLR--ELQTPTRAPDRSTLVTL----------NVLSP 536
            ..:..|.          |.:|.     ||::  ....|:.|.:.:|.::|          .|:..
Human   139 LERCFPEAEKLKQETKLLSQWK-----HYIQCDGSPDPSVAQEMNTFISLWKEKTNETFEEVIEK 198

  Fly   537 IRISSELSKR-------------EDGSV----------QSTLANQFSPPLKSLLKQSITYGHFP- 577
            .::...|.::             :|.::          |..|..:|....:.||||:.|.....
Human   199 SKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLHLKFGVATEILLKQASTLADLDS 263

  Fly   578 ------LRGEPIANF---NLDKSLNKIEIMKLEKMC---LPRIISSFKFPSEFVE---DQLTSEA 627
                  ::.|.:..:   ||.|:.....:...|...   :|||:::.......:.   |.:::..
Human   264 GNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQIGFEIPRILATSDIAVRLLHTHYDHVSALH 328

  Fly   628 LKSRPNR--------LVKRLDTETAVEAKTPAEIYFEYESQER-----PERAFPIFEK--TVAIE 677
            ..|.|::        |||  |....||.....|:..|.:.|||     .|....:.|:  .:.::
Human   329 PVSTPSKEYTSAVTELVK--DDVKNVEKAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEVK 391

  Fly   678 FSSAAELMPSIECGNKATACGLLSTLEDIKEKYLQRPQELLDQIQVQVSKKSEKKAEKWENKNAD 742
            .|||.|...:|:|                 |:.::...|.:...|:.:.:.|.:|.:.:|:
Human   392 MSSAEEESEAIKC-----------------EREMKVLSETVSAAQLLLVENSSEKPDFFED---- 435

  Fly   743 GRSSAFSFRDRSSFANVNGKKTALDAKTKINETEIMITISTSENKMEIPSTSK-------TRTRR 800
                  :..|...|..:.|          :...:|          :|:|...|       ....:
Human   436 ------NVVDLCQFTTLGG----------VYHLDI----------LELPPQCKPVKGWMIVEILK 474

  Fly   801 SGSVMKRRSTRKSARMEDMDRFRPMD-----------SEPPVLL------DHWTKEYIMESQINL 848
            .|..........:...|..:.|.|::           .|.||::      .||..:.|.......
Human   475 EGLQKYTYPPETTEEFETENAFPPIEVTLEVHENVIFFEDPVVVRWDAEGKHWRTDGISNVSYKP 539

  Fly   849 ETNTLTFRTDRLGIFGLAFKRYEHFPFRDWCLQPSEDNPDEVILSLDTFHVRMFFYISARGVRGY 913
            :...:||..|..|...|....:.:.|::.|.|:|.:.|  :|:|::.|....:...|...
Human   540 KERLVTFSLDTFGPVTLIQDAHINMPYQSWELRPLDVN--KVLLTVTTVFTEIQIQIKEN----- 597

  Fly   914 VTDLVKGYTAKPVKYLEIVE-----PISDFRELRKLLIERNLNIFAENDASYYITNGYFSIKHIA 973
             ..::.....|..|::.|:|     ||.....|:    |..||||....:.:|:   ..:.|...
Human   598 -LCMLSSIKLKDKKHISILEGTWMTPIPFIIALK----EAGLNIFPTRHSHFYV---IINNKVPL 654

  Fly   974 LELHTYNTMALQCKLMKFCRSSWNRLAQRRDIIVEMK-----IAKDNSDYSEVTMRITPEKTTFV 1033
            :|:..|..|||......|..|.||.|.....::.:::     ...:|.:::  .:..:.::...:
Human   655 VEVKAYRQMALLSSAFAFGWSKWNLLCNSTKVVFKVREHLTEACTENPNWA--LLMFSGDRAQRL 717

  Fly  1034 KISEMCSDDVNVVKLRYEDTWRNVNNYNDFGQAIYSL-----NPHTLEGSNKDAMLFV-YLKRLL 1092
            ||.|........:|   |:|        :|...:|.:     :...:|........|| .:..:|
Human   718 KIKEESEAFSEALK---EET--------EFHSTLYHMVKDFASEEAMEKVRSSNCQFVNSVCHML 771

  Fly  1093 NEIRPLSYS 1101
            ...|.||||
Human   772 LSTRLLSYS 780

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33287	NP_001137993.1	Casc1_C	835..1053	CDD:432508	47/227 (21%)
DNAI7	XP_005253463.1	Casc1_N	98..288	CDD:464947	31/194 (16%)
		Casc1_C	525..691	CDD:432508	41/180 (23%)