Protein Alignment CG33286 and DNAI7

DIOPT Version :10

• Sequence 1: NP_001097653.1
• Gene: CG33286 / 2768984
• FlyBaseID: FBgn0053286
• Length: 1062
• Species: Drosophila melanogaster
• Sequence 2: XP_005253463.1
• Gene: DNAI7 / 55259
• HGNCID: 29599
• Length: 780
• Species: Homo sapiens
• Alignment Length: 1117
• Identity: 182/1117 - (16%)
• Similarity: 344/1117 - (30%)
• Gaps: 472/1117 - (42%)

  Fly     1 MVKRKSTAAAKPVAEPILRYPLISENEVMDR--------------EARYMSRLNDFTVSAELVKG 51
            :::.:.....|...|..|:|    |.|.|:|              ||:.:.|.|:......|:
Human    81 LLQEEEERRLKEEEEARLKY----EKEEMERLEIQRIEKEKWHRLEAKDLERRNEELEELYLL-- 139

  Fly    52 AQRDFYNQEVDRMFRE-----HWEHHLRCDGLPRPYLPVEVRTFMSKIRFYDEIETNNSMDWTLS 111
             :|.|  .|.:::.:|     .|:|:::|||.|.|.:..|:.||:|   .:.| :||.:.:   .
Human   140 -ERCF--PEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFIS---LWKE-KTNETFE---E 194

  Fly   112 VDERSILTQNIFRVDKTRRMMMVNKDNPGEHYDHNVQMCLNALKQMDAMLDNEAEMVRMSDKRQK 176
            |.|:|.:..|:  ::|.:.:::  :..|.:..|.|:.....::.|:..:|..:..:
Human   195 VIEKSKVVLNL--IEKLKFILL--ETPPCDLQDKNIIQYQESILQLQELLHLKFGV--------- 246

  Fly   177 DVIEVYTEVEAEIGDLFDRLTYRVLSMQDAYMESKDGRVA--VW-SYTCNPWRLDLWGLRNVPII 238
             ..|:..:..:.:.||......:|:         ||..|.  || :...||..      |:|
Human   247 -ATEILLKQASTLADLDSGNMEKVI---------KDENVTLYVWANLKKNPRH------RSV--- 292

  Fly   239 FDQLELPVMLAEFSATSVEVQIPKSVLKDCVTIRSLHMDFDNISQNAKSFEIAVKASLNYPNAGI 303
                       .||.|.:..:||:.:....:.:|.||..:|::|
Human   293 -----------RFSETQIGFEIPRILATSDIAVRLLHTHYDHVS--------------------- 325

  Fly   304 VDIENSVVNEWHMQLEIQEETLNLMLTRRREYED-MMELIAEKTEQAAKA-AKQTDPDKMVKITI 366
                                .|:.:.|..:||.. :.||:.:..:...|| :|:.:.:.
Human   326 --------------------ALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEES------ 364

  Fly   367 PKAPKEPPYVPTGMFPDIYEDFLRIEESQYSGYLDEVCHPRHLDMQPFEINLRDYIMLGGIYSIM 431
             |..:...::       |.|:.:::||.|
Human   365 -KQQERGSHL-------IQEEEIKVEEEQ------------------------------------ 385

  Fly   432 FIRRPDQTQFEQFNIVLHEDGRVVHILTEMKADIPVEAVRKSNIGRKTRETYRGTKIKLEDDELP 496
                                           .||.|                   |:...::|
Human   386 -------------------------------GDIEV-------------------KMSSAEEE-- 398

  Fly   497 YFIVTLQVAADLCKWSEPVVCHFITEKDFIPTDYKRESYWVPTMQSVIRHSEYAGRSMLNLGSQI 561
                           ||.:.|             :||       ..|:..:..|.:.:|   .:.
Human   399 ---------------SEAIKC-------------ERE-------MKVLSETVSAAQLLL---VEN 425

  Fly   562 SGDSANIFRPSLRSFLRQSKVGAAPKPGVPIEDFKLEKKLSHLEIRTLEKYCLP----RIISSFK 622
            |.:..:.|..::....:.:.:|.                :.||:|..|...|.|    .|:
Human   426 SSEKPDFFEDNVVDLCQFTTLGG----------------VYHLDILELPPQCKPVKGWMIV---- 470

  Fly   623 FPVDFRDEKREFIRQGPRALVKRPDAEEVVTQVKTLDFNYNSQVLGPERMYPYFPQMDPIKYPIP 687
                      |.:::|.:.....|:..|        :|.       .|..:|
Human   471 ----------EILKEGLQKYTYPPETTE--------EFE-------TENAFP------------- 497

  Fly   688 FDDLEPGPVNPTSALELLKTFDNIKSKYQEKHIDLISQPDEQDKKSKQKKLGVKEEDDVPEAQIA 752
                   |:..|     |:..:|:                            :..||.|.....|
Human   498 -------PIEVT-----LEVHENV----------------------------IFFEDPVVVRWDA 522

  Fly   753 KRKFSKLGDKVRSSVKTDRMDRVTVGSDKSSVKTNPMSEEQVTHWTTKYVKDVVIDRETNSITFK 817
            :.|                                        ||.|..:.:|....:...:||.
Human   523 EGK----------------------------------------HWRTDGISNVSYKPKERLVTFS 547

  Fly   818 TDRLGLLGLAFKRYEHFPFRNWSLQPNEENPDEIILCVDTFHVRIFFYI---TCKGVRGYVTDLS 879
            .|..|.:.|....:.:.|:::|.|:|.:.|  :::|.|.|....|...|   .|         :.
Human   548 LDTFGPVTLIQDAHINMPYQSWELRPLDVN--KVLLTVTTVFTEIQIQIKENLC---------ML 601

  Fly   880 KGYTAKPIKYLEIVE-----PISDFRQMRQIFISKNINIFAENDASFYIENGYFSMKHVALEMHT 939
            .....|..|::.|:|     ||.....:::    ..:|||....:.||:   ..:.|...:|:..
Human   602 SSIKLKDKKHISILEGTWMTPIPFIIALKE----AGLNIFPTRHSHFYV---IINNKVPLVEVKA 659

  Fly   940 YNIMALHCKLMKFYRSSWNRLADRRDIIMGMK-----IAKDNSDYSEV--------TMRITPEKT 991
            |..|||......|..|.||.|.:...::..::     ...:|.:::.:        .::|..|..
Human   660 YRQMALLSSAFAFGWSKWNLLCNSTKVVFKVREHLTEACTENPNWALLMFSGDRAQRLKIKEESE 724

  Fly   992 TFVQISENCSDKVNVIVLNYINTWRNIGNFTDLHQAINSMVPN-ATE-----VRNKDSILLYYVT 1050
            .|   ||...::                  |:.|..:..||.: |:|     ||:.:...:..|.
Human   725 AF---SEALKEE------------------TEFHSTLYHMVKDFASEEAMEKVRSSNCQFVNSVC 768

  Fly  1051 RMLKEIRLLSFS 1062
            .||...||||:|
Human   769 HMLLSTRLLSYS 780

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33286	NP_001097653.1	Casc1_C	793..1014	CDD:432508	48/241 (20%)
DNAI7	XP_005253463.1	Casc1_N	98..288	CDD:464947	49/228 (21%)
		Casc1_C	525..691	CDD:432508	43/223 (19%)