DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trl and ZBTB14

DIOPT Version :9

Sequence 1:	NP_001261846.1	Gene:	Trl / 2768981	FlyBaseID:	FBgn0013263	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001137295.1	Gene:	ZBTB14 / 7541	HGNCID:	12860	Length:	449	Species:	Homo sapiens

Alignment Length:	379	Identity:	73/379 - (19%)
Similarity:	122/379 - (32%)	Gaps:	110/379 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 DYGTSLVSAIQLLRCHGDLVDCTLAAGGRSFPAHKIVLCAASPFLLDLLKNTPC-KHPVVMLAGV 78
            |:.|..:..:...|..|:..|..:......|.||:.||.|.|.:...|.|.... ...|:.:..:
Human    17 DHKTLFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSSVIEIDFL 81

  Fly    79 NANDLEALLEFVYRGEVSVDHAQLPSLLQAAQCLNIQGLAPQTVTKDDYTTHSIQLQHMIPQHHD 143
            .::..|.:|.::|..::||....:..::.:.|.|.|:.|......|.|
Human    82 RSDIFEEVLNYMYTAKISVKKEDVNLMMSSGQILGIRFLDKLCSQKRD----------------- 129

  Fly   144 QDQLIATIATAPQQTVHAQVVEDIHHQGQ-----ILQATTQTNAAGQQQTIVTTDAAKHDQAVIQ 203
                    .::|.:           :.||     .|:.......|...|.....:....|.
Human   130 --------VSSPDE-----------NNGQSKSKYCLKINRPIGDAADTQDDDVEEIGDQDD---- 171

  Fly   204 AFLPARKRKPRVKKMSPTAPKISKVEGMDTIMGTPTSSHGSGS------VQQ-VLGENGAEGQLL 261
                           ||:.         ||:.|||.|.....|      ||: :|.|.|:|
Human   172 ---------------SPSD---------DTVEGTPPSQEDGKSPTTTLRVQEAILKELGSE---- 208

  Fly   262 SSTPIIKSEGQKVETIVTMDPNNMIPVTSANAATGEITPAQGATGSSGGNTSGVLSTPKAKRAKH 326
             ....:...||:||::.|.:..::          |..|| |..|.:.|      :|..|.::.
Human   209 -EVRKVNCYGQEVESMETPESKDL----------GSQTP-QALTFNDG------MSEVKDEQT-- 253

  Fly   327 PPGTEKPRSRSQSE--------QPATCPICYAVIRQSRNLRRHLELRHFAKPGV 372
             ||.....|..:.|        :...|..|.........||:|.:|....:|.|
Human   254 -PGWTTAASDMKFEYLLYGHHREQIACQACGKTFSDEGRLRKHEKLHTADRPFV 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trl	NP_001261846.1	BTB	27..117	CDD:279045	21/90 (23%)
		BTB	35..118	CDD:197585	19/83 (23%)
		GAGA	319..372	CDD:150045	12/60 (20%)
ZBTB14	NP_001137295.1	BTB_POZ_ZBTB14	18..131	CDD:349513	25/137 (18%)
		Nuclear localization signal. /evidence=ECO:0000255	50..66		6/15 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..194		12/68 (18%)
		C2H2 Zn finger	279..299	CDD:275368	5/19 (26%)
		SFP1	<303..383	CDD:227516	2/4 (50%)
		C2H2 Zn finger	307..327	CDD:275368	73/379 (19%)
		zf-H2C2_2	319..344	CDD:404364
		C2H2 Zn finger	335..355	CDD:275368
		C2H2 Zn finger	363..383	CDD:275368
		C2H2 Zn finger	391..407	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910