DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trl and ZSCAN5C

DIOPT Version :9

Sequence 1:	NP_001261846.1	Gene:	Trl / 2768981	FlyBaseID:	FBgn0013263	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001345342.1	Gene:	ZSCAN5C / 649137	HGNCID:	34294	Length:	496	Species:	Homo sapiens

Alignment Length:	395	Identity:	75/395 - (18%)
Similarity:	118/395 - (29%)	Gaps:	139/395 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 LLDLLKNT--PCKHPVVMLAGVNANDLEALLEFVYRGEVSVDHAQLPSLLQ-------AAQCLNI 114
            |.|||:|.  |.|..||...|     .|.|::     |..|:.|:.|:.::       :.:..::
Human   115 LEDLLRNNRRPKKWSVVSFLG-----KEYLMQ-----ESDVEMAEAPASVRDDPRHVSSQRTSSV 169

  Fly   115 QGLAPQTVTKDDYTTHSIQLQHMIP---QHHDQDQLI--ATI------ATAPQQTVHAQVVEDIH 168
            ..:.|:    :...:..:|....:|   :..::|.|:  .|:      |..|:.|:...:.||..
Human   170 NQMCPE----EGQASQELQTLPRVPALFRRQEEDFLLPETTVMKGDPKALRPKPTLEKDLEEDRE 230

  Fly   169 HQGQILQATTQ-----TNAAGQQQTIVTTDAAKHDQAVIQAFLPARKRKPRVKKMSPTAPKISKV 228
            ....:.....|     |...|.::       .|..|           ::..|:.:....|....|
Human   231 ENPGLTSPEPQLPNSPTGVVGAKE-------GKEPQ-----------KRASVENVDADTPSACVV 277

  Fly   229 EGMDTIMGTPTSSHGSGSVQQVLGENGAEGQLLSSTPIIKSEGQKVETIVTMDPNNMIPVTSANA 293
            |       ...|:| |||....|...|.:.....:|.|.:.|.|
Human   278 E-------REASTH-SGSRGDALNLRGLKRSKPDATSISQEEPQ--------------------- 313

  Fly   294 ATGEITPAQGATGSSGGNTSGVLSTPKAKRAKHPPGTE----------------KPR------SR 336
              ||.||............:.|.|...|....||.|.|                |.|      :|
Human   314 --GEATPVGNRESPGQAEINPVHSPGPAGPVSHPSGQEVKELLPFACEVCGKRFKYRGKLAVHTR 376

  Fly   337 SQS-----------------------------EQPATCPICYAVIRQSRNLRRHLELRHFAKPGV 372
            |.:                             |:|.||.||.....|...|:.|.......||..
Human   377 SHTGERLFQCNLCGKRFMQRIGLQFHQRTHTGERPYTCDICQKQFTQKSYLKCHKRSHTGEKPFE 441

  Fly   373 KKEKK 377
            .|:.|
Human   442 CKDCK 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trl	NP_001261846.1	BTB	27..117	CDD:279045	16/66 (24%)
		BTB	35..118	CDD:197585	16/67 (24%)
		GAGA	319..372	CDD:150045	20/103 (19%)
ZSCAN5C	NP_001345342.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38
		SCAN	40..124	CDD:153421	5/8 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	149..188		3/42 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	203..347		35/192 (18%)
		zf-C2H2	356..378	CDD:333835	3/21 (14%)
		C2H2 Zn finger	358..378	CDD:275368	3/19 (16%)
		zf-H2C2_2	371..393	CDD:372612	2/21 (10%)
		C2H2 Zn finger	386..406	CDD:275368	0/19 (0%)
		COG5048	410..>473	CDD:227381	12/37 (32%)
		C2H2 Zn finger	414..434	CDD:275368	6/19 (32%)
		C2H2 Zn finger	442..462	CDD:275368	2/5 (40%)
		zf-C2H2	468..490	CDD:333835
		C2H2 Zn finger	470..490	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000