DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trl and BTBD18

DIOPT Version :9

Sequence 1:	NP_001261846.1	Gene:	Trl / 2768981	FlyBaseID:	FBgn0013263	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001138573.1	Gene:	BTBD18 / 643376	HGNCID:	37214	Length:	712	Species:	Homo sapiens

Alignment Length:	411	Identity:	95/411 - (23%)
Similarity:	153/411 - (37%)	Gaps:	83/411 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 DCTLAAGGRSFPAHKIVLCAASPFLLDLL-KNTPCK--HPVVMLAGVNANDLEALLEFVYRGEVS 96
            |..|.|.|.:.|||..:|.|.|||..:.| :..|.:  ..|:.|.|:..:.|..|::|:|..|:.
Human    35 DVLLQAEGEAVPAHCCILSACSPFFTERLERERPAQGGKVVLELGGLKISTLRKLVDFLYTSEME 99

  Fly    97 VDHAQLPSLLQAAQCLNIQGLAPQTVTKDDYTTHSIQLQH----MIPQHHDQD-QLIATIATAPQ 156
            |...:...:|.||:.|.:..|            .|:||:.    ..||....: :.:...:.||
Human   100 VSQEEAQDVLSAARQLRVSEL------------ESLQLEGGKLVKAPQGRRLNRECLQPTSAAP- 151

  Fly   157 QTVHAQVVEDIHHQGQILQATTQT---------NAAGQQQTIVTTDAAKHDQAVIQAFLPARKR- 211
              :.|:||...||....| .|.||         .:.|:::.....:....|.......|..:.|
Human   152 --ISARVVTPSHHPHTPL-PTNQTPCPLGAIRLKSLGKEEGPQENNRQNADNLSGTLLLKRKARA 213

  Fly   212 --KPRVKKMSPTA----PKISKVE-GMDTIMGTPTSSHGSGSVQQVLGENGAEGQLLSSTPIIKS 269
              .|:.|..||::    |:.:|.: .:|..:.:|.|.:.|           .:..|| ...|..|
Human   214 CPTPQEKNSSPSSHSQEPRENKNDTALDPTVLSPPSLYPS-----------VDKHLL-PRKIRLS 266

  Fly   270 EGQKVETIVTMDPNNM------IPVT---------SANAATGEITPAQGATG--SSGGNTSGVLS 317
            ..:....|.|..|:::      :|.|         |.|..|.|..|..|...  .|..|.||:..
Human   267 RSKPSPGICTSKPSSILSGSSSVPATPGRRLWRQRSVNKETPEDKPKPGRASPLQSTPNPSGLGK 331

  Fly   318 TPKAKRAKHPPGTEKPRSRSQSE--------QPATCPICYAVIRQSRNLRRHLELRHFAKPGVKK 374
            |..::  |..|....|.|.|..|        :......|:.|: |...|:...:......||  .
Human   332 TGGSR--KRSPEVRAPNSDSAEEGQVGRVKLRKIVNGTCWEVV-QETPLKNTQDSPQIPDPG--G 391

  Fly   375 EKKSKSGNDTTLDSSMEMNTT 395
            :.:..||......:..||:.|
Human   392 DFQEPSGTQPFSSNEQEMSPT 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trl	NP_001261846.1	BTB	27..117	CDD:279045	27/84 (32%)
		BTB	35..118	CDD:197585	27/85 (32%)
		GAGA	319..372	CDD:150045	11/60 (18%)
BTBD18	NP_001138573.1	BTB	24..120	CDD:306997	27/84 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..176		7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..355		37/156 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	374..410		6/37 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	653..676
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	691..712
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910