DRSC/TRiP Functional Genomics Resources

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Protein Alignment Trl and BCL6

DIOPT Version :9

Sequence 1:NP_001261846.1 Gene:Trl / 2768981 FlyBaseID:FBgn0013263 Length:623 Species:Drosophila melanogaster
Sequence 2:NP_001124317.1 Gene:BCL6 / 604 HGNCID:1001 Length:706 Species:Homo sapiens


Alignment Length:545 Identity:102/545 - (18%)
Similarity:166/545 - (30%) Gaps:185/545 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSLPMNSLYSLTWGDYGTSLVSAIQLLRCHGDLVDCTLAAGGRSFPAHKIVLCAAS----PFLLD 61
            |:.|.:|....|  .:.:.::..:..||....|.|..:......|.|||.||.|.|    ....|
Human     1 MASPADSCIQFT--RHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTD 63

  Fly    62 LLKNTPCKHPVVML-AGVNANDLEALLEFVYRGEVSVDHAQLPSLLQAA---------------- 109
            .||   |...|:.| ..:|......||:|:|...:::....:.:::..|                
Human    64 QLK---CNLSVINLDPEINPEGFCILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKFI 125

  Fly   110 ----------------QCLNIQGLAPQTV------------------------------------ 122
                            :.||.:.|.||.:                                    
Human   126 KASEAEMVSAIKPPREEFLNSRMLMPQDIMAYRGREVVENNLPLRSAPGCESRAFAPSLYSGLST 190

  Fly   123 TKDDYTTHSIQLQHM------------------------------------IPQHHDQDQLIATI 151
            ....|:.:|    |:                                    :|..:.:..|..:.
Human   191 PPASYSMYS----HLPVSSLLFSDEEFRDVRMPVANPFPKERALPCDSARPVPGEYSRPTLEVSP 251

  Fly   152 AT------APQQTVHAQVVEDIHH---QGQILQATTQTNA-------AGQQQTIVTTDAAKHDQA 200
            ..      :|::|:..:...|:|:   :|....|.:..||       |.:::     :....:..
Human   252 NVCHSNIYSPKETIPEEARSDMHYSVAEGLKPAAPSARNAPYFPCDKASKEE-----ERPSSEDE 311

  Fly   201 VIQAFLPARKRKPRVKKMSPTAPKISKVEGMDTIMGTPTSSHGS--GSVQQVLGENGAEGQLLSS 263
            :...|.|......|...:||.:|:.|     |....:||.|..|  ..:.|..|...|:    |.
Human   312 IALHFEPPNAPLNRKGLVSPQSPQKS-----DCQPNSPTESCSSKNACILQASGSPPAK----SP 367

  Fly   264 TPIIKSEGQKVETIVTMDPN-NMIPVTSANAATGEITP-------------------AQGATG-S 307
            |.......:|.:.||....| |..|.....|..|.::|                   .|..|. |
Human   368 TDPKACNWKKYKFIVLNSLNQNAKPEGPEQAELGRLSPRAYTAPPACQPPMEPENLDLQSPTKLS 432

  Fly   308 SGGNTSGVLSTPKAKRAKHPPG---TEKPRSRSQSEQPATC--PICYAVIRQSRNLRRHLEL-RH 366
            :.|..|.:   |:|.|..:...   |..|||.|:|..|...  |.|.:...||   .:|.|: .|
Human   433 ASGEDSTI---PQASRLNNIVNRSMTGSPRSSSESHSPLYMHPPKCTSCGSQS---PQHAEMCLH 491

  Fly   367 FAKPGVKKEKKSKSGNDTTLDSSME 391
            .|.|...:|........:  |||.|
Human   492 TAGPTFPEEMGETQSEYS--DSSCE 514

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TrlNP_001261846.1 BTB 27..117 CDD:279045 26/126 (21%)
BTB 35..118 CDD:197585 23/119 (19%)
GAGA 319..372 CDD:150045 19/58 (33%)
BCL6NP_001124317.1 BTB 22..126 CDD:279045 24/106 (23%)
BTB 33..126 CDD:197585 21/95 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 317..349 10/36 (28%)
Required for interaction with NuRD complex and for transcriptional repressor activity 376..379 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 407..467 14/62 (23%)
C2H2 Zn finger 520..541 CDD:275368
C2H2 Zn finger 548..568 CDD:275368
zf-H2C2_2 560..585 CDD:290200
C2H2 Zn finger 576..596 CDD:275368
zf-H2C2_2 588..613 CDD:290200
C2H2 Zn finger 604..624 CDD:275368
zf-H2C2_2 616..641 CDD:290200
C2H2 Zn finger 632..652 CDD:275368
zf-H2C2_2 645..669 CDD:290200
C2H2 Zn finger 660..678 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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