DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trl and ZBTB2

DIOPT Version :9

Sequence 1:	NP_001261846.1	Gene:	Trl / 2768981	FlyBaseID:	FBgn0013263	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_065912.1	Gene:	ZBTB2 / 57621	HGNCID:	20868	Length:	514	Species:	Homo sapiens

Alignment Length:	640	Identity:	118/640 - (18%)
Similarity:	199/640 - (31%)	Gaps:	217/640 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 DYGTSLVSAIQLLRCHGDLVDCTLAAGGRSFPAHKIVLCAASPFLLDLLKNTPCKHPVVMLAGVN 79
            ::|..|:..:...|..|.|.|||:|.|...|.|||.||.:.|.:...|
Human     5 NHGLILLQQLNAQREFGFLCDCTVAIGDVYFKAHKSVLASFSNYFKML----------------- 52

  Fly    80 ANDLEALLEFVYRGEVSVDHAQLPSLLQAAQCLNIQGLAPQTVTKD--DYTTHSIQLQHMIPQHH 142
                     ||:               |.::|:.   |.|..:..|  .|..|.:....|.||..
Human    53 ---------FVH---------------QTSECVR---LKPTDIQPDIFSYLLHLMYTGKMAPQLI 90

  Fly   143 DQDQLIATIATAPQQTVHAQVVEDIHHQGQILQATTQTNAAGQQ--------QTIVTTDAAKHD- 198
            |..:|             .|.::.:|....|.:|:..:..|...        .::.....|.|.
Human    91 DPVRL-------------EQGIKFLHAYPLIQEASLASQGAFSHPDQVFPLASSLYGIQIADHQL 142

  Fly   199 -QAVIQAFLPAR-KRKPRVKKMSPTAPKISKVEGMDTIMGTPTSSHGSGSVQQVLGENGAEGQLL 261
             ||...|..|.: .|.||        |:.|::                 |.:||     .|...|
Human   143 RQATKIASAPEKLGRDPR--------PQTSRI-----------------SQEQV-----PEASQL 177

  Fly   262 SSTPIIKSEGQKVETIVTMDPNNMIPVTSANAATGEITPAQGATGSSGGNTSGVLSTPKAKRAKH 326
            |         |....:..::..||.|   ::.....::|.             ::|||.   ...
Human   178 S---------QLTSNLAQVNRTNMTP---SDPLQTSLSPE-------------LVSTPV---PPP 214

  Fly   327 PPGTEKPRSRSQS-EQPATCPICYAVIRQSRNLRRHLELRHFAKPGVKKEKKS--------KSGN 382
            |||.|.....|.| ||||:..|.:                  .||.:.|...|        ..|.
Human   215 PPGEETNLEASSSDEQPASLTIAH------------------VKPSIMKRNGSFPKYYACHLCGR 261

  Fly   383 DTTLDSS----MEMNTTAEGDNTVGSDGAGGAGSAGGQSSATSGKKSSSGSSGSGSGALSSSGSV 443
            ..||.||    ::::|           |.....|..|:|.......|::...|..:..:..:|.:
Human   262 RFTLRSSLREHLQIHT-----------GVPFTSSQQGESRVPLTLCSNAADLGKDAMEVPEAGMI 315

  Fly   444 --PQVQTVQSLHTLQGVQVKKDP------DAQQQQQQQQQQQQQQQQQAMTVSGATGGQVQQQVQ 500
              .::|.:.....:.|.|..:.|      |....:|..|:::.::::...|:.|
Human   316 SDSELQHISDSPIIDGQQQSETPPPSDIADIDNLEQADQEREVKRRKYECTICG----------- 369

  Fly   501 QVQQQVQQQQQQQQQQQQQLQHHQIIDSSGNITTAT---TSAQAAAAAQQQAAGQQQQLVAQSDG 562
                       ::..|:...:.|..|.:......:|   :..:|..||:.....|........|.
Human   370 -----------RKFIQKSHWREHMYIHTGKPFKCSTCDKSFCRANQAARHVCLNQSIDTYTMVDK 423

  Fly   563 S-------ESGAPLSIAQVQTLQGHQIIGNLNQVNITDFQQQQPQQQQQQQQQQQ 610
            .       |.|:.:....|||.:.:       :.|:.|.....|.:..:...|.|
Human   424 QTLELCTFEEGSQMDNMLVQTNKPY-------KCNLCDKTFSTPNEVVKHSCQNQ 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trl	NP_001261846.1	BTB	27..117	CDD:279045	20/89 (22%)
		BTB	35..118	CDD:197585	17/82 (21%)
		GAGA	319..372	CDD:150045	14/53 (26%)
ZBTB2	NP_065912.1	BTB	14..>84	CDD:306997	25/113 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	149..231		28/139 (20%)
		C2H2 Zn finger	256..276	CDD:275368	5/19 (26%)
		zf-C2H2	363..385	CDD:306579	4/43 (9%)
		C2H2 Zn finger	365..385	CDD:275368	4/41 (10%)
		zf-H2C2_2	377..399	CDD:316026	3/21 (14%)
		C2H2 Zn finger	392..443	CDD:275368	8/50 (16%)
		C2H2 Zn finger	450..466	CDD:275368	3/15 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910