DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trl and zbtb2

DIOPT Version :9

Sequence 1:	NP_001261846.1	Gene:	Trl / 2768981	FlyBaseID:	FBgn0013263	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001016668.1	Gene:	zbtb2 / 549422	XenbaseID:	XB-GENE-977864	Length:	514	Species:	Xenopus tropicalis

Alignment Length:	449	Identity:	83/449 - (18%)
Similarity:	148/449 - (32%)	Gaps:	156/449 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 DYGTSLVSAIQLLRCHGDLVDCTLAAGGRSFPAHKIVLCAASPF--LLDLLKNTPCKHPVVMLAG 77
            ::|..|:..:...|..|.|.|||:|.|...|.|||.||.:.|.:  :|.:.:.:.|       ..
Frog     5 NHGLILLQQLNAQREFGFLCDCTVAIGDVYFKAHKSVLASFSNYFKMLFVHQTSEC-------VR 62

  Fly    78 VNANDLEA-----LLEFVYRGEVS---VDHAQLPS---------LLQAAQCLNIQGL-------- 117
            :.:.|::.     ||..:|.|:::   :|..:|..         |:|.|...:..|.
Frog    63 LKSTDIQPDIFSYLLHLMYTGKMAPQLIDPVRLEQGIKFLHAFPLIQEASLASHGGFSHADQVFP 127

  Fly   118 -----------------------APQTVTKD----------DYTTHSIQLQHMIPQHHDQDQLIA 149
                                   |.:..|:|          |.|:.::|:          .||.:
Frog   128 LASSLYGIQIADHQIRPPAKVTPATEKATRDTRSQTSRLGQDTTSENVQI----------SQLPS 182

  Fly   150 TIATAPQ------QTVHAQVVEDIHHQGQILQATTQTNAAGQQQTIVTTDAAKHDQAVIQAFLPA 208
            .:.||.:      :||||.:..:.  ...:|...|.......:::  .||.......:...
Frog   183 ALPTANRTNLTFSETVHAPLSPEA--SSSVLPTATSVEENSMEES--PTDEQNTSLTIAHV---- 239

  Fly   209 RKRKPRVKKMSPTAPKI--------------SKVEGMDTIMGTPTSSHGSG----SVQQVLGENG 255
               ||.:.|.:.:.||.              |..|.:....|.|.|| .:|    |:......||
Frog   240 ---KPSIMKRNGSFPKYYACHLCGRRFNLRSSLREHLQLHTGIPFSS-AAGQTETSISPSFCNNG 300

  Fly   256 AEGQLLSSTPIIKSEGQKVETIVTMDPNNMIPVTSANAATGEITPAQGATGSSGGNTSGVLSTPK 320
            |:        :.|...:..|..:..| ::|..::.:....|:
Frog   301 AD--------LGKESMETTEAGIISD-SDMPQISDSPIIDGQ----------------------- 333

  Fly   321 AKRAKHPPGT---------EKPRSRSQSEQPATCPICYAVIRQSRNLRRHLELRHFAKP 370
             ::|:.||.|         :..:.|....:...|.||.....|..:.|.|:.: |..||
Frog   334 -QQAETPPPTDIADIDNLEQADQEREVKRRKYECSICGRKFIQKSHWREHMYI-HTGKP 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trl	NP_001261846.1	BTB	27..117	CDD:279045	27/108 (25%)
		BTB	35..118	CDD:197585	25/132 (19%)
		GAGA	319..372	CDD:150045	14/61 (23%)
zbtb2	NP_001016668.1	BTB_POZ_ZBTB2	3..117	CDD:349502	29/118 (25%)
		ZnF_C2H2	254..276	CDD:197676	2/21 (10%)
		C2H2 Zn finger	256..276	CDD:275368	2/19 (11%)
		zf-C2H2	364..386	CDD:333835	6/22 (27%)
		C2H2 Zn finger	366..386	CDD:275368	6/20 (30%)
		zf-H2C2_2	378..400	CDD:372612	5/14 (36%)
		C2H2 Zn finger	393..443	CDD:275368
		C2H2 Zn finger	450..466	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910