DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trl and mod(mdg4)

DIOPT Version :9

Sequence 1:	NP_001261846.1	Gene:	Trl / 2768981	FlyBaseID:	FBgn0013263	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_788698.1	Gene:	mod(mdg4) / 49228	FlyBaseID:	FBgn0002781	Length:	610	Species:	Drosophila melanogaster

Alignment Length:	533	Identity:	123/533 - (23%)
Similarity:	202/533 - (37%)	Gaps:	128/533 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YSLTWGDYGTSLVSAIQLLRCHGDLVDCTLAAGGRSFPAHKIVLCAASPFLLDLLKNTPCK-HPV 72
            :||.|.::.|:|.:......|.|||||.:|||.|:...||::||...|||...:....|.. |.:
  Fly     7 FSLCWNNFNTNLSAGFHESLCRGDLVDVSLAAEGQIVKAHRLVLSVCSPFFRKMFTQMPSNTHAI 71

  Fly    73 VMLAGVNANDLEALLEFVYRGEVSVDHAQLPSLLQAAQCLNIQGLA--------PQTVTKDDYTT 129
            |.|..|:.:.|:.|::|:|.|||:|....||:.:..|:.|.|:||.        ||..:......
  Fly    72 VFLNNVSHSALKDLIQFMYCGEVNVKQDALPAFISTAESLQIKGLTDNDPAPQPPQESSPPPAAP 136

  Fly   130 HSIQLQHMIPQHHDQDQLIATIATAPQQTVHAQV--VEDIHHQGQILQATTQTNAAGQQQTIVTT 192
            | :| |..||....|.|       .|:.:...::  |:|  ..|...|:||        |.::.|
  Fly   137 H-VQ-QQQIPAQRVQRQ-------QPRASARYKIETVDD--GLGDEKQSTT--------QIVIQT 182

  Fly   193 DAAKHDQAVIQAFLPARKRKPRVKKMSPTAPKISKVEGMDTIMGTPTSSHGSGSVQQVLGENGAE 257
            .||  .||.|            |::..| .....:::......||.|::       .::..|...
  Fly   183 TAA--PQATI------------VQQQQP-QQAAQQIQSQQLQTGTTTTA-------TLVSTNKRS 225

  Fly   258 GQLLSSTPIIKSEGQKVETIVT----MDPNNMIPVTSANAATGEITPAQGATGSSGGNTSGVLST 318
            .|..|.||...|.|.|.....|    |||.:....|.| ..|.::.|.|....:|      |:|.
  Fly   226 AQRSSLTPASSSAGVKRSKTSTSANVMDPLDSTTETGA-TTTAQLVPQQITVQTS------VVSA 283

  Fly   319 PKAKRAKHPPGTEKPRSRSQSEQPATCPICYAVIRQSRNLRRHLELRHFAKPGVKKEKKSKSGND 383
            .:||..:..|...:.......:.|                   :||...::|...::....:|:
  Fly   284 AEAKLHQQSPQQVRQEEAEYIDLP-------------------MELPTKSEPDYSEDHGDAAGD- 328

  Fly   384 TTLDSSMEMNTTAEG----DNTVG-----------SDGAG---GAGSAGGQSSATSGKK------ 424
                        |||    |:|.|           ::.||   .|.::||..:||:.|.
  Fly   329 ------------AEGTYVEDDTYGDMRYDDSYFTENEDAGNQTAANTSGGGVTATTSKAVVKQQS 381

  Fly   425 ---------SSSGSSGSGSGALSSSGSVPQVQTVQSLHTLQGVQVKKDPDAQQQQQQQQQQQQQQ 480
                     .:||..|:.....::|.|..::...:.......|:.:.......::.|.....::.
  Fly   382 QNYSESSFVDTSGDQGNTEAQAATSASATKIPPRKRGRPKTKVEDQTPKPKLLEKLQAATLNEEA 446

  Fly   481 QQQAMTVSGATGG 493
            .:.|:..|...||
  Fly   447 SEPAVYASTTKGG 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trl	NP_001261846.1	BTB	27..117	CDD:279045	35/90 (39%)
		BTB	35..118	CDD:197585	31/83 (37%)
		GAGA	319..372	CDD:150045	7/52 (13%)
mod(mdg4)	NP_788698.1	BTB	22..118	CDD:279045	37/95 (39%)
		BTB	33..118	CDD:197585	32/84 (38%)
		FLYWCH	452..512	CDD:282369	3/8 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9675
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.010