DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trl and ttk

DIOPT Version :9

Sequence 1:	NP_001261846.1	Gene:	Trl / 2768981	FlyBaseID:	FBgn0013263	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001189329.1	Gene:	ttk / 48317	FlyBaseID:	FBgn0003870	Length:	813	Species:	Drosophila melanogaster

Alignment Length:	676	Identity:	146/676 - (21%)
Similarity:	234/676 - (34%)	Gaps:	223/676 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YSLTWGDYGTSLVSAI-QLLRCHGD-LVDCTLAAGGRSFPAHKIVLCAASPFLLDLLKNTPCKHP 71
            :.|.|.::.::|:|.. |||  |.: ..|.|||..|:...|||:||.|.||:...|..:.|.|||
  Fly     8 FCLRWNNHQSNLLSVFDQLL--HAETFTDVTLAVEGQHLKAHKMVLSACSPYFNTLFVSHPEKHP 70

  Fly    72 VVMLAGVNANDLEALLEFVYRGEVSVDHAQLPSLLQAAQCLNIQGL--------------APQTV 122
            :|:|..|..:|:::||:|:||||||||..:|.:.|:.|:.|.|:||              |....
  Fly    71 IVILKDVPYSDMKSLLDFMYRGEVSVDQERLTAFLRVAESLRIKGLTEVNDDKPSPAAAAAGAGA 135

  Fly   123 TKDDYTTHSIQLQ----HMIPQHHDQDQLIATIATAPQQTVHAQVVEDIHHQGQILQATTQTNAA 183
            |..:.|..:.|||    :::|| .::.|....:|:|..                          |
  Fly   136 TGSESTATTPQLQRIQPYLVPQ-RNRSQAGGLLASAAN--------------------------A 173

  Fly   184 GQQQTIVTTDAAKHDQAVIQAFLPARKR-KPRVKKMSPTAPKISKVEGMDTIMGTPTSSHGSGSV 247
            |...|:..     ....:..|.:|.||| :||            |:.|         ||:|:|:.
  Fly   174 GNTPTLPV-----QPSLLSSALMPKRKRGRPR------------KLSG---------SSNGTGND 212

  Fly   248 QQVLGENGAEGQLLSSTPIIKSEGQKVETIVTMDPNNMIPVTSANAATGEITPAQGATGSSGGNT 312
            ..                             ..|..||:. .|::...|::     ...|..||.
  Fly   213 YD-----------------------------DFDRENMMN-DSSDLGNGKM-----CNESYSGND 242

  Fly   313 SGVLSTPKAKRAKHPPGTEKPRSRSQSEQPATCPICYAVIRQSRNLRRHLELRHFAKPGVKKEKK 377
            .|  |......|.|.....:.|....|             ::|:|.:.|..:.|       .|..
  Fly   243 DG--SDDNQPNAGHTDDLNESRDSLPS-------------KRSKNSKDHRVVSH-------HEDN 285

  Fly   378 SKSGNDTTLDSSMEMNTTAEGDNTVGSDGAGGAGSAGGQSSATSGKKSSSGSSGSGSGALSSSGS 442
            |.|...|.....:..........|:.:...|  ||:.|.|...|..:.|           ....|
  Fly   286 STSVTPTKATPELSQRLFGSSSTTISATAPG--GSSTGPSETISLLEIS-----------DERES 337

  Fly   443 VPQVQTVQSLHTLQGVQVK---KDPDAQQQQQQQQQQQQQQQQQAMTVSGATGGQVQQQVQ---- 500
            .|     ..|.|:.|::::   ....|||...|...:.:.:.:|| |.|..:...::||::
  Fly   338 AP-----VHLPTILGLKIRAINTTTPAQQGSPQTPTKSKPKIRQA-TGSNNSNSLLKQQLRGGAK 396

  Fly   501 ----------------QVQQQVQQQQQQQQQQQQQLQHHQIIDSSGNITTATTSAQAAAAAQQQA 549
                            ......::|.::..::.|.           .:.........|.||:|||
  Fly   397 DPEVPPATRITGAVTPNAALNAEEQSKEMPKKNQD-----------EVNACIGLHSLANAAEQQA 450

  Fly   550 AGQQQQLVAQSDGSESGAPLSIAQVQTLQGHQII----GNLNQVNITDFQQQQPQQQQQQQQQ-- 608
            |                   .:|....|. ||::    .|.:.:|.||:.|||.|:......|
  Fly   451 A-------------------QVASTGNLH-HQLLLHMAANNSMLNTTDYYQQQQQESPSSAGQFM 495

  Fly   609 -----------QQQQQQQQQQTQQTL 623
                       ||.:..:......||
  Fly   496 DDDLELLSLNDQQDKSDEPDHEMVTL 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trl	NP_001261846.1	BTB	27..117	CDD:279045	40/90 (44%)
		BTB	35..118	CDD:197585	40/96 (42%)
		GAGA	319..372	CDD:150045	8/52 (15%)
ttk	NP_001189329.1	BTB	23..119	CDD:279045	44/97 (45%)
		BTB	34..119	CDD:197585	40/84 (48%)
		C2H2 Zn finger	612..638	CDD:275370
		zf-C2H2_4	646..669	CDD:290605
		C2H2 Zn finger	648..669	CDD:275370
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9675
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.010