DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trl and lola

DIOPT Version :9

Sequence 1:	NP_001261846.1	Gene:	Trl / 2768981	FlyBaseID:	FBgn0013263	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_788308.3	Gene:	lola / 44548	FlyBaseID:	FBgn0283521	Length:	970	Species:	Drosophila melanogaster

Alignment Length:	735	Identity:	162/735 - (22%)
Similarity:	272/735 - (37%)	Gaps:	217/735 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YSLTWGDYGTSLVSAIQLLRCHGDLVDCTLAAGGRSFPAHKIVLCAASPFLLDLLKNTPCKHPVV 73
            :.|.|.::.::|:|....|..:..||||||||.|:...|||:||.|.||:...||:....|||:.
  Fly     7 FCLRWNNHQSTLISVFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPYFATLLQEQYDKHPIF 71

  Fly    74 MLAGVNANDLEALLEFVYRGEVSVDHAQLPSLLQAAQCLNIQGLAPQTVTKDDYTTHSIQLQHMI 138
            :|..|...:|.|:::::|||||::...||.:||:||:.|.|:||:      |:.|.
  Fly    72 ILKDVKYQELRAMMDYMYRGEVNISQDQLAALLKAAESLQIKGLS------DNRTG--------- 121

  Fly   139 PQHHDQDQLIATIATAPQQTVHAQVVEDIHHQGQILQATT--QTNAA-----GQQQTIVTTDAAK 196
                      ..:|..|:.:.|       |..|::..|.|  ||..|     |...|......::
  Fly   122 ----------GGVAPKPESSGH-------HRGGKLSGAYTLEQTKRARLATGGAMDTSGDVSGSR 169

  Fly   197 HDQAVIQAFLPARKRKPRVKKMSPTAPKISKVEGMDTIMGTPTSSHGSGSVQQVLGENGAEGQLL 261
            ...:     .|:|:|: :|::.|               |......:.:.||.|....|
  Fly   170 EGSS-----SPSRRRR-KVRRRS---------------MENDAHDNSNSSVLQAAASN------- 206

  Fly   262 SSTPIIKSEGQKVETIVTMDPNNMIPVTSANAATGEITPAQGATGSSGGNTSGVLSTPKAKRAKH 326
                                 .:::..|.|..|...:...|.::|.:.|.:|...||.:.:....
  Fly   207 ---------------------QSILQQTGAGLAVSALVTTQLSSGPAAGTSSQASSTQQQQPLTS 250

  Fly   327 PPGTEKPRS---RSQSEQPATCPICYAVIRQSRNLRRHLELRHFAKPGVKKEKKSKSGNDTTLDS 388
            ...|:|..|   .|.:..||:.....|.::|:     ||.           ::::::.:|.....
  Fly   251 TNVTKKTESAKLTSSTAAPASGASASAAVQQA-----HLH-----------QQQAQTTSDAINTE 299

  Fly   389 SMEMNTTAEGDNTVGSDGAGGAGSA-GGQSSATSGKKSSSGSSGSGSGAL----------SSSGS 442
            :::..:........|.|.....||| ||.:|||....:|:.:|...:|.:          |||..
  Fly   300 NVQAQSQGGAQGVQGDDEDIDEGSAVGGPNSATGPNPASASASAVHAGVVVKQLASVVDKSSSNH 364

  Fly   443 VPQVQ--TVQSLHTLQGVQVKK--DPDAQQQQ------QQQQQQQQQQQQQAMTVSGATG----- 492
            ..:::  :|.|:.:...::.|.  |.||..:.      .::....::..|.|.|..|..|
  Fly   365 KHKIKDNSVSSVGSEMVIEPKAEYDDDAHDENVEDLTLDEEDMTMEELDQTAGTSQGGEGSSQTY 429

  Fly   493 ------------GQVQQQVQQVQQQVQQQQQQQQQQQQQ---------LQHHQIIDSS------- 529
                        |.:.|..||...|..:|.:.:|.:..|         |:.:.|:.:.
  Fly   430 ATWQHDRSQDELGLMAQDAQQRDPQASKQDKGEQTEGAQDEFELDDCLLESNDIVITQNKDGFVL 494

  Fly   530 -----GNITTATTSAQAAAAAQQ-QA-------AGQQQQLV------AQSDGSE--------SGA 567
                 ||||.|......|.|.|| ||       |||....:      |.:..||        :..
  Fly   495 HVKKLGNITAAKLEENQAVAQQQGQAAVTVTGPAGQPTPTITELLNAAAASHSEPKPTLTTLTST 559

  Fly   568 PLSI-----------------AQVQTLQGHQIIGNLNQVNITDFQQQQPQQQQQQQQQQ------ 609
            |:.:                 ..:.|...|.....::..:|.....|:|..|:..||.|
  Fly   560 PIKLPSSECELINIKKIIPATTTIATHHPHTSSTIIHPHHIIQHVSQEPHHQEHHQQHQTIHIEE 624

  Fly   610 -----QQQQQQQQQTQ-QTL 623
                 ||..|||...| ||:
  Fly   625 VPQTSQQHHQQQHHHQLQTV 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trl	NP_001261846.1	BTB	27..117	CDD:279045	40/89 (45%)
		BTB	35..118	CDD:197585	38/82 (46%)
		GAGA	319..372	CDD:150045	10/55 (18%)
lola	NP_788308.3	BTB	22..117	CDD:279045	42/100 (42%)
		BTB	33..117	CDD:197585	39/89 (44%)
		C2H2 Zn finger	905..925	CDD:275368
		C2H2 Zn finger	935..955	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10615
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.010