DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trl and lov

DIOPT Version :9

Sequence 1:	NP_001261846.1	Gene:	Trl / 2768981	FlyBaseID:	FBgn0013263	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_611994.3	Gene:	lov / 38007	FlyBaseID:	FBgn0266129	Length:	1143	Species:	Drosophila melanogaster

Alignment Length:	611	Identity:	120/611 - (19%)
Similarity:	192/611 - (31%)	Gaps:	222/611 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YSLTWGDYGTSLVSAIQLLRCHGDLVDCTLAAGGRSFPAHKIVLCAASPFLLDLLKNTPCKHPVV 73
            |||.|.::...::.|...|.....|||.||.....|..|||:||.|.|||...:...|||||||:
  Fly   115 YSLRWNNHQNHILRAFDALLKTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFAETPCKHPVI 179

  Fly    74 MLAGVNANDLEALLEFVYRGEVSVDHAQLPSLLQAAQCLNIQGLAPQTV---------TKDDY-- 127
            :|.......::|:::|:||||:||...:|.:|:||.:.|.::||...:|         :.||:
  Fly   180 VLKDFRGWVVQAIVDFMYRGEISVPQQRLQTLIQAGESLQVRGLVESSVPEHTPTPAASPDDFGM 244

  Fly   128 ---------------------------------------TTHSIQLQHMIPQHHDQD-------- 145
                                                   ...::.|:....|..|:|
  Fly   245 LDTSMLSSTFEDECPTMVRPSKGGKLLMPSARLFGNASSAIAALGLRRKREQESDRDLESDQELG 309

  Fly   146 ------------------------QLIATIATAPQQTVHAQVVEDIHHQGQILQATTQTNAAGQQ 186
                                    .|..|.|.:.|..:..:::|......:  :|..|.|:.|:.
  Fly   310 GSSPMPRRKQARPRRRSGDVPHDFTLNKTDAESLQTVIKHELLERAERDQE--EAPDQDNSQGEA 372

  Fly   187 QTIVTTDAAKHDQAVIQAFLPARKRKPRVKKMSPTAPKISKVEGMDTIMGTPTSSHGSGSVQQVL 251
            :.|.::              ||:....|.|:.     |..|.||.|.......:.|     |..|
  Fly   373 EKISSS--------------PAKTLVERAKEQ-----KSMKEEGSDQPRSLNENHH-----QLEL 413

  Fly   252 GENGAEGQLLSSTPIIKSEGQKVETIV------------------TMDPN--------------- 283
            .:...:.|     ...:.|.|.:|.::                  .|.||
  Fly   414 DDEDDDDQ-----DHEEEEEQDIEELIHTTNELRRQAAAAAANAAAMSPNPSPCLSDGPEDLCTT 473

  Fly   284 ----NMI--PVTSANA----------------------------ATGEITPAQGATGSSGGNTSG 314
                .:|  |.:||:.                            |....|.....|..|||| :|
  Fly   474 KKGKELISGPSSSADCESNNNNSSKLQDNNQRIMLSLKDIRQLNANPNPTAIHTPTSCSGGN-NG 537

  Fly   315 VLSTPKAKRAKHPPGTEKP---------RSRSQSEQPATCPICYAVIRQSRNLRRHLE------L 364
            :|:.|       |||...|         ....:::..|......|......:...|:|      |
  Fly   538 LLTFP-------PPGLRPPGLPDSPPCHMEALEAQMHAAAAAAVAAAGSGEHPFHHMEHQMEMSL 595

  Fly   365 RHFAKPGVKKEKKSKSGNDTTLDSSMEMNTTAEGDNTVGSDGAGGAGSAGGQSSATSGKKSSSGS 429
            ...|......:::.:...|     ..:.|..|  .|.:|..|....|...|         ...|:
  Fly   596 AAAAAAAAMHQREPRDPRD-----GRDHNAFA--SNLLGPMGMPPFGGHNG---------GHPGN 644

  Fly   430 SGSGSGALSSSGSVPQVQTVQSLHTL 455
            ||.|:|.   .|.....:..:|::.|
  Fly   645 SGPGNGC---PGQAAHERLEESMNRL 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trl	NP_001261846.1	BTB	27..117	CDD:279045	37/89 (42%)
		BTB	35..118	CDD:197585	35/82 (43%)
		GAGA	319..372	CDD:150045	11/67 (16%)
lov	NP_611994.3	BTB	130..225	CDD:279045	39/94 (41%)
		BTB	141..226	CDD:197585	36/84 (43%)
		HTH_psq	791..834	CDD:283007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10615
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.010