DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trl and Zbtb44

DIOPT Version :9

Sequence 1:	NP_001261846.1	Gene:	Trl / 2768981	FlyBaseID:	FBgn0013263	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	XP_006242830.1	Gene:	Zbtb44 / 363035	RGDID:	1308984	Length:	616	Species:	Rattus norvegicus

Alignment Length:	450	Identity:	86/450 - (19%)
Similarity:	157/450 - (34%)	Gaps:	131/450 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 YGTSLVSAIQLLRCHGDLVDCTLAAGGRSFPAHKIVLCAASPFLLDLL--------KNTPCKHPV 72
            :...::..:.:||..|...|.|:....|.|.|||:||.|.|.|....|        ||      |
  Rat    13 HSQEMLGKLNMLRNDGHFCDITIRVQDRIFRAHKVVLAACSDFFRTKLVGQTEDENKN------V 71

  Fly    73 VMLAGVNANDLEALLEFVYRGEVSVDHAQLPSLLQAAQCLNIQGLAPQTVTKDDYTTHSIQLQHM 137
            :.|..|.......|||:.|...:|::...:..:|.||..:.:..:|.   |..::...||
  Rat    72 LDLHHVTVTGFIPLLEYAYTATLSINTENIIDVLAAASYMQMFSVAS---TCSEFMKSSI----- 128

  Fly   138 IPQHHDQDQLIATIATAPQQTVHAQVVEDIHHQGQILQATTQTNAAGQQQTI--VTTDAAKHDQA 200
                     |..|..:.|::.:.|         ||  :.::..|...:..:|  |:::.:..::.
  Rat   129 ---------LWNTPNSQPEKGLDA---------GQ--ENSSNCNFTSRDGSISPVSSECSAVERT 173

  Fly   201 VIQAFLPARKRKPRVKKMSPTAP-KISKVEGMDTIMGTPTS-----------------SHGSGSV 247
            :.......||||..: .|||.:| |.|.......::.:..|                 :...|..
  Rat   174 IPVCRESRRKRKSYI-VMSPESPVKCSTQTNSPQVLNSSASYAENRNQPVDSSLAFPWTFPFGID 237

  Fly   248 QQVLGENG--AEGQLLSSTPIIKSEGQKVETIVTMDPNNMI------------------------ 286
            :::..|..  ||.......|.....|:::...||.:.....
  Rat   238 RRIQPEKAKQAENTRTLELPGPSEAGRRMADYVTCESTKTTLPLGTEEDVRVKVERLSDEEVHEE 302

  Fly   287 ---PVTSANAATGE---------------ITPAQGATGS-SGGNTSGV------LST-------P 319
               ||:::.::..:               |:|...:.|| ..|.|.|:      .||       .
  Rat   303 VSQPVSASQSSLSDQQTVPGSEPVQEDLLISPQSSSIGSVDEGVTEGLPTLQSTSSTNAHADEDD 367

  Fly   320 KAKRAKHP---------PGTEKPRSRSQSEQPATCPICYAVIRQSRNLRRHLELRHFAKP 370
            :.:..::|         ..||:| |.:..::|..||.|.....:.:||::|:.:....||
  Rat   368 RLENVQYPYQLYIAPSTSSTERP-SPNGPDRPFQCPTCGVRFTRIQNLKQHMLIHSGIKP 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trl	NP_001261846.1	BTB	27..117	CDD:279045	29/97 (30%)
		BTB	35..118	CDD:197585	26/90 (29%)
		GAGA	319..372	CDD:150045	13/60 (22%)
Zbtb44	XP_006242830.1	BTB	21..125	CDD:279045	31/112 (28%)
		BTB	32..128	CDD:197585	28/104 (27%)
		COG5048	383..>449	CDD:227381	12/44 (27%)
		zf-C2H2	399..421	CDD:278523	6/21 (29%)
		C2H2 Zn finger	401..421	CDD:275368	6/19 (32%)
		zf-H2C2_2	413..438	CDD:290200	4/13 (31%)
		C2H2 Zn finger	429..449	CDD:275368
		C2H2 Zn finger	457..476	CDD:275368
		C2H2 Zn finger	489..511	CDD:275371
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000