DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trl and psq

DIOPT Version :9

Sequence 1:	NP_001261846.1	Gene:	Trl / 2768981	FlyBaseID:	FBgn0013263	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001369078.1	Gene:	psq / 36118	FlyBaseID:	FBgn0263102	Length:	1170	Species:	Drosophila melanogaster

Alignment Length:	695	Identity:	181/695 - (26%)
Similarity:	255/695 - (36%)	Gaps:	193/695 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YSLTWGDYGTSLVSAIQLLRCHGDLVDCTLAAGGRSFPAHKIVLCAASPFLLDLLKNTPCKHPVV 73
            :||.|.:|..::.|..|.||.....||.||:....|..|||:||.|.|.:...||...|||||.:
  Fly    10 FSLRWNNYQNTMTSVFQQLREDLSFVDVTLSCEHGSLKAHKVVLSACSTYFQKLLLENPCKHPTI 74

  Fly    74 ML-AGVNANDLEALLEFVYRGEVSVDHAQLPSLLQAAQCLNIQGLAPQTVTKDDYT-------TH 130
            :| |.:...||:.:::||||||:.|..::|..||:.|:.|.|:||.......||..       |.
  Fly    75 ILPADIIFTDLKTIIDFVYRGEIDVTESELQGLLRTAEQLKIKGLCETAENADDLNDAATATITV 139

  Fly   131 SIQLQH----------MIP-----------QHHDQDQLIATIATAPQQTVHAQVVEDIHHQ---- 170
            |..:|.          ::|           |||.|.|.........||.||||..:....|
  Fly   140 SENIQQAVVGNIVNAAIVPGAPSPSLEQQQQHHQQQQQQQAQEQHQQQQVHAQQQQQQQQQINAA 204

  Fly   171 ---------------GQILQATTQTNA---AGQQQTIVTTDAAKHDQAVIQAFLPARKRKPRVKK 217
                           ||:|.::...::   ||.||...|...           |....||.|:|:
  Fly   205 LLTQHGVSSGSVSLSGQLLSSSASGSSGSLAGGQQASQTPSG-----------LQPTPRKSRLKR 258

  Fly   218 MSPTAPKISKVEGMDTIMGTPTSSHGSGSVQQVLGENGAEGQLLSSTP-------IIKSEGQKVE 275
            ..  :|.:|...|..:..|:     .|||.||            ...|       .|..:||...
  Fly   259 SK--SPDLSSGGGAGSSGGS-----SSGSTQQ------------QPQPAHHHHPQTILIQGQNPN 304

  Fly   276 TIVTMD---PNNMIPVT----SANAATGEITPAQGATGSSGGNTSGVLSTPKAK---RAKHPPG- 329
            :||::.   ..|.|||:    .::|...|.....|.....||:|.|...:.:..   ..:|.|.
  Fly   305 SIVSLQQTADGNYIPVSGSGDDSDAEDHEHEHNHGHGHGHGGHTHGHGHSHEHSHDHEHEHKPNK 369

  Fly   330 ---TE----KPRSRSQSEQPATCPIC------YAVIRQSRNLRRHLELRHFAKPGV--------- 372
               ||    .|.|.|.|.......:.      .|::.|....|...:.::....|:
  Fly   370 ICKTEHSVASPASNSSSASNNAAGVSGVTSTGQAIVTQIVVARDGKDTKNMTSLGMGMNGGLLGV 434

  Fly   373 -------KKEKKSKSGNDTTLDSSMEM------------NTT--AEGDNTVGSDGAGGAGSAGGQ 416
                   ..|..:.|....|:...:::            |||  .:.||.:            .|
  Fly   435 PMGFLDFTPEPPAPSATPVTVTEHVDLSCNPSTDTRDLSNTTEPLDIDNHL------------AQ 487

  Fly   417 SSATSGKKSSSGSSGSGSGALSSSGSVPQV--QTVQSLHTL-------QGVQVKKDPDAQQQQQQ 472
            ......:......|...:|..|:|..|..:  :.:::.|..       |..|......|.||.||
  Fly   488 QIHRLDQSPMHSISHHHTGDESNSNLVQHIKSEVIEAKHLAAQHHALSQAQQQHAHHQAHQQHQQ 552

  Fly   473 QQQQQQQQQQQAMTVSGATGGQVQQQVQQVQQQVQQQQQQQQQQQQQLQHHQIIDSSGNITTATT 537
            .||||.|||||.:            ..||:..|.|.||||||||||| ||||           ..
  Fly   553 HQQQQHQQQQQHL------------HAQQLLAQSQLQQQQQQQQQQQ-QHHQ-----------QQ 593

  Fly   538 SAQAAAAAQQQAAGQQQQLVAQSDGSESGAPLSIAQVQTLQGHQI 582
            ..||||||  .|||    :..|..|..:.|.:..|.|..:...||
  Fly   594 QQQAAAAA--AAAG----VHGQHGGHVTHADIGGATVMEIDPSQI 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trl	NP_001261846.1	BTB	27..117	CDD:279045	38/90 (42%)
		BTB	35..118	CDD:197585	36/83 (43%)
		GAGA	319..372	CDD:150045	11/69 (16%)
psq	NP_001369078.1	BTB_POZ_BAB-like	34..118	CDD:349624	36/83 (43%)
		HTH_psq	717..>747	CDD:283007
		HTH_psq	767..804	CDD:283007
		HTH_psq	821..866	CDD:283007
		HTH_psq	873..916	CDD:283007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10615
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.010