DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trl and Bcl6b

DIOPT Version :9

Sequence 1:	NP_001261846.1	Gene:	Trl / 2768981	FlyBaseID:	FBgn0013263	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001101749.1	Gene:	Bcl6b / 360551	RGDID:	1563179	Length:	472	Species:	Rattus norvegicus

Alignment Length:	429	Identity:	83/429 - (19%)
Similarity:	132/429 - (30%)	Gaps:	174/429 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 YGTSLVSAIQLLRCHGDLVDCTLAAGGRSFPAHKIVLCAASPFLLDLLKNTPCKHPVVMLAGVNA 80
            :.:.::|.:..||..|.|.|.||..||:...|||.||.|.|.|...:.:..         |||..
  Rat    20 HSSDVLSNLNELRLRGILTDVTLLVGGQPLRAHKAVLIACSGFFYSIFRGR---------AGVGV 75

  Fly    81 NDL------EA-----LLEFVYRGEVSVDHAQLPSLLQAAQCLNIQGLAPQTVTKDDYTTHSIQL 134
            :.|      ||     ||:|:|...:.:..|..|::|.||..|                    |:
  Rat    76 DVLSLPGGPEARGFAPLLDFMYTSRLRLSPATAPAVLAAATYL--------------------QM 120

  Fly   135 QHMIPQHHDQDQLIATIATAPQQTVHAQVVEDIHHQGQILQATTQTNAAGQQQTIVTTDAAKHDQ 199
            :|::...|                             :.:||:.:....
  Rat   121 EHVVQACH-----------------------------RFIQASYEPLGI---------------- 140

  Fly   200 AVIQAFLPARKRKPRVKKMSPTAPKISKVEGMDTIMGTPTSSHG-------SGSVQQVLGENGAE 257
                :..|.....||    .||.|.          .|:|..|.|       |.|..|
  Rat   141 ----SLRPMEAEPPR----PPTVPP----------PGSPRRSEGHPDPPTESRSCSQ-------- 179

  Fly   258 GQLLSSTPIIKSEGQKVETIVTMDPNNMIPVTSANAATGEITP------------AQGATGSSGG 310
            |....::|..|:...|....:.::..:....:.|..::|:..|            :..::.|..|
  Rat   180 GSPSPASPDPKACNWKKYKFIVLNSQSSQAGSLAGESSGQPCPQARLPSGDEACSSSSSSSSEEG 244

  Fly   311 NTSGV-----------------------LSTPKA----KRAKHPPGTE----------------- 331
            .|.|:                       |.||.|    |:|..|||:|
  Rat   245 ATPGLQSRLSLATTTARFKCGALANNSYLFTPPAQETSKQAHPPPGSECLSCQNCEAVAGCSSGI 309

  Fly   332 KPRSRSQSEQPATCPICYAVIRQSRNLRRHLELRHFAKP 370
            :|.:....::|..|.:|.:..|...||..|..:....||
  Rat   310 EPLAPGDEDKPYKCQLCRSAFRYKGNLASHRTVHTGEKP 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trl	NP_001261846.1	BTB	27..117	CDD:279045	33/100 (33%)
		BTB	35..118	CDD:197585	29/93 (31%)
		GAGA	319..372	CDD:150045	18/73 (25%)
Bcl6b	NP_001101749.1	BTB	28..132	CDD:279045	36/161 (22%)
		BTB	39..131	CDD:197585	32/149 (21%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		zf-H2C2_2	335..360	CDD:290200	5/14 (36%)
		C2H2 Zn finger	351..371	CDD:275368
		zf-H2C2_2	363..388	CDD:290200
		C2H2 Zn finger	379..399	CDD:275368
		zf-H2C2_2	391..416	CDD:290200
		C2H2 Zn finger	407..427	CDD:275368
		zf-H2C2_2	420..444	CDD:290200
		C2H2 Zn finger	435..453	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000