DRSC/TRiP Functional Genomics Resources

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Protein Alignment Trl and ZBTB44

DIOPT Version :9

Sequence 1:NP_001261846.1 Gene:Trl / 2768981 FlyBaseID:FBgn0013263 Length:623 Species:Drosophila melanogaster
Sequence 2:NP_001357148.1 Gene:ZBTB44 / 29068 HGNCID:25001 Length:616 Species:Homo sapiens


Alignment Length:491 Identity:93/491 - (18%)
Similarity:159/491 - (32%) Gaps:171/491 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 YGTSLVSAIQLLRCHGDLVDCTLAAGGRSFPAHKIVLCAASPFLLDLL--------KNTPCKHPV 72
            :...::..:.:||..|...|.|:....:.|.|||:||.|.|.|....|        ||      |
Human    13 HSQEMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAEDENKN------V 71

  Fly    73 VMLAGVNANDLEALLEFVYRGEVSVDHAQLPSLLQAAQCLNIQGLAPQTVTKDDYTTHSIQLQHM 137
            :.|..|.......|||:.|...:|::...:..:|.||..:.:..:|.   |..::...||     
Human    72 LDLHHVTVTGFIPLLEYAYTATLSINTENIIDVLAAASYMQMFSVAS---TCSEFMKSSI----- 128

  Fly   138 IPQHHDQDQLIATIATAPQQTVHAQVVEDIHHQGQILQATTQTNAAGQQQTIVTTDAAKHDQAVI 202
                     |..|..:.|::.:.|         ||  :..:..|...:..:|   .....:.:|:
Human   129 ---------LWNTPNSQPEKGLDA---------GQ--ENNSNCNFTSRDGSI---SPVSSECSVV 170

  Fly   203 QAFLPA-----RKRKPRVKKMSPTAPKISKVEGMDTIMGTPTSSHGSGSVQQVLGENG------- 255
            :..:|.     ||||..: .|||.:|         ...||.|||      .|||..:.       
Human   171 ERTIPVCRESRRKRKSYI-VMSPESP---------VKCGTQTSS------PQVLNSSASYSENRN 219

  Fly   256 ----------------------------AEGQLLSSTPIIKSEGQKVETIVTMDPNNMI------ 286
                                        ||.......|.....|:::...||.:.....      
Human   220 QPVDSSLAFPWTFPFGIDRRIQPEKVKQAENTRTLELPGPSETGRRMADYVTCESTKTTLPLGTE 284

  Fly   287 ---------------------PVTSANAATGE---------------ITPAQGATGS-SGGNTSG 314
                                 ||:::.::..:               |:|...:.|| ..|.:.|
Human   285 EDVRVKVERLSDEEVHEEVSQPVSASQSSLSDQQTVPGSEQVQEDLLISPQSSSIGSVDEGVSEG 349

  Fly   315 VLSTPKAKRAKHPP----------------------GTEKPRSRSQSEQPATCPICYAVIRQSRN 357
            :.:.........||                      .||:| |.:..::|..||.|.....:.:|
Human   350 LPTLQSTSSTNAPPDDDDRLENVQYPYQLYIAPSTSSTERP-SPNGPDRPFQCPTCGVRFTRIQN 413

  Fly   358 LRRHLELRHFAKPGVKKEKKSKSGNDTTLDSSMEMN 393
            |::|: |.|   .|:|..:..:.|...|...|::|:
Human   414 LKQHM-LIH---SGIKPFQCDRCGKKFTRAYSLKMH 445

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TrlNP_001261846.1 BTB 27..117 CDD:279045 28/97 (29%)
BTB 35..118 CDD:197585 25/90 (28%)
GAGA 319..372 CDD:150045 15/74 (20%)
ZBTB44NP_001357148.1 BTB_POZ_ZBTB44 15..130 CDD:349537 32/137 (23%)
COG5048 383..>449 CDD:227381 19/68 (28%)
C2H2 Zn finger 401..421 CDD:275368 7/20 (35%)
zf-H2C2_2 413..438 CDD:338759 8/28 (29%)
C2H2 Zn finger 429..449 CDD:275368 4/17 (24%)
C2H2 Zn finger 457..476 CDD:275368
zf-C2H2 487..508 CDD:333835
C2H2 Zn finger 489..511 CDD:275371
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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