DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trl and BCL6B

DIOPT Version :9

Sequence 1:	NP_001261846.1	Gene:	Trl / 2768981	FlyBaseID:	FBgn0013263	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_862827.2	Gene:	BCL6B / 255877	HGNCID:	1002	Length:	479	Species:	Homo sapiens

Alignment Length:	415	Identity:	86/415 - (20%)
Similarity:	141/415 - (33%)	Gaps:	111/415 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 YGTSLVSAIQLLRCHGDLVDCTLAAGGRSFPAHKIVLCAASPFLLDLLKNTPCKHPVVMLAGVNA 80
            :.:.::..:..||..|.|.|.||..||:...|||.||.|.|.|...:.:..         |||..
Human    20 HSSDVLGNLNELRLRGILTDVTLLVGGQPLRAHKAVLIACSGFFYSIFRGR---------AGVGV 75

  Fly    81 NDL------EA-----LLEFVYRGEVSVDHAQLPSLLQAAQCLNIQGLAPQTVTKDDYTTHSIQL 134
            :.|      ||     ||:|:|...:.:..|..|::|.||..|.::              |.:|.
Human    76 DVLSLPGGPEARGFAPLLDFMYTSRLRLSPATAPAVLAAATYLQME--------------HVVQA 126

  Fly   135 QHMIPQHHDQDQLIA---------TIATAP------QQTVHAQVVEDIH--HQGQILQATTQTNA 182
            .|...|...:...|:         |..|||      :...|.....:..  .||....|:....|
Human   127 CHRFIQASYEPLGISLRPLEAEPPTPPTAPPPGSPRRSEGHPDPPTESRSCSQGPPSPASPDPKA 191

  Fly   183 AG--QQQTIVTTDAAKHDQAVI----------QAFLPARKRKPRVKKMSPTAPKISKVEGMDTIM 235
            ..  :.:.||....|....:::          ||.||:..........|.::.:...:.|..:.:
Human   192 CNWKKYKYIVLNSQASQAGSLVGERSSGQPCPQARLPSGDEASSSSSSSSSSSEEGPIPGPQSRL 256

  Fly   236 GTPTSSHGSGSVQQVLGENGAEGQLLSSTP-IIKSEGQKVETIVTMDPNNMIPVTSANAATGEIT 299
             :||::    :||...|..       :||| ::.|:.|                .::.:.:....
Human   257 -SPTAA----TVQFKCGAP-------ASTPYLLTSQAQ----------------DTSGSPSERAR 293

  Fly   300 PAQGATGSSGGNTSGVLSTPKAKRAKHPPGTEKP-------------------RSRSQSEQPATC 345
            |..|:...|..|...|........:..|...:||                   |:....|:|..|
Human   294 PLPGSEFFSCQNCEAVAGCSSGLDSLVPGDEDKPYKCQLCRSSFRYKGNLASHRTVHTGEKPYHC 358

  Fly   346 PICYAVIRQSRNLRRHLELRHFAKP 370
            .||.|...:..||:.|..:....||
Human   359 SICGARFNRPANLKTHSRIHSGEKP 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trl	NP_001261846.1	BTB	27..117	CDD:279045	33/100 (33%)
		BTB	35..118	CDD:197585	29/93 (31%)
		GAGA	319..372	CDD:150045	15/71 (21%)
BCL6B	NP_862827.2	BTB_POZ	19..132	CDD:365784	36/134 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	143..190		8/46 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	210..259		6/49 (12%)
		C2H2 Zn finger	330..350	CDD:275368	1/19 (5%)
		COG5048	354..>411	CDD:227381	10/30 (33%)
		C2H2 Zn finger	358..378	CDD:275368	7/19 (37%)
		zf-H2C2_2	370..395	CDD:372612	5/14 (36%)
		C2H2 Zn finger	386..406	CDD:275368
		zf-C2H2	412..434	CDD:333835
		C2H2 Zn finger	414..434	CDD:275368
		zf-H2C2_2	427..451	CDD:372612
		C2H2 Zn finger	442..460	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000