DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trl and ZBTB49

DIOPT Version :9

Sequence 1:	NP_001261846.1	Gene:	Trl / 2768981	FlyBaseID:	FBgn0013263	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001317554.1	Gene:	ZBTB49 / 166793	HGNCID:	19883	Length:	765	Species:	Homo sapiens

Alignment Length:	737	Identity:	146/737 - (19%)
Similarity:	226/737 - (30%)	Gaps:	230/737 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LVSAIQLLRCHGDLVDCTLAAGGRSFPAHKIVLCAASPFLLDLLKNTPC-KHPVVMLAGVNANDL 83
            |:..:...|..|.|.||.|...|..|.|||.||.|.|.:...|.:|:.. |:.|..|...|.:.:
Human    11 LLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNSSSQKNDVFHLDVKNVSGI 75

  Fly    84 EALLEFVYRGEVSVDHAQLPSLLQAAQCLNIQG-------------------------------L 117
            ..:|:|:|...:.::...:..:|..||||.:|.                               |
Human    76 GQILDFMYTSHLDLNQDNIQVMLDTAQCLQVQNVLSLCHTFLKSATVVQPPGMPCNSTLSLQSTL 140

  Fly   118 APQT--VTKDDYTTHSIQLQHMIPQHHDQDQLIATIATAPQQTVHAQVVEDIHHQ-GQILQATTQ 179
            .|..  |..::|..|.:|......|.:         .|..:...||....:.||. |:|.:....
Human   141 TPDATCVISENYPPHLLQECSADAQQN---------KTLDESHPHASPSVNRHHSAGEISKQAPD 196

  Fly   180 T-----------------------------NAAGQQQTIV---------TTD---------AAKH 197
            |                             :|||..|..|         :||         |..|
Human   197 TSDGSCTELPFKQPNYYYKLRNFYSKQYHKHAAGPSQERVVEQPFAFSTSTDLTTVESQPCAVSH 261

  Fly   198 DQAVIQA-------FL--PARKRKPR----------VKKMS-PTAPKISKVEGMDT-----IMGT 237
            .:.::::       ||  |.....|.          ||:|. ..|..:.|:..:.:     .:..
Human   262 SECILESPEHLPSNFLAQPVNDSAPHPESDATCQQPVKQMRLKKAIHLKKLNFLKSQKYAEQVSE 326

  Fly   238 PTSSHGSGSVQQVLGENGAEGQLLSSTPIIKSEGQKVETIVTMDPNNMIPVTSANAATGEITPAQ 302
            |.|..|.....:...:|..|.....|     :|.::.|.:|:.:..|.|..|.        .|..
Human   327 PKSDDGLTKRLESASKNTLEKASSQS-----AEEKESEEVVSCENFNCISETE--------RPED 378

  Fly   303 GATGSSGGNTSGVLSTPK-------AKRAKHPPGTEKPRSRSQSEQPATCPICYAVIRQSRNLRR 360
            .|.......|   |.:.:       .|..|||...|..:.....|:|..|.||.....|:.||:.
Human   379 PAALEDQSQT---LQSQRQYACELCGKPFKHPSNLELHKRSHTGEKPFECNICGKHFSQAGNLQT 440

  Fly   361 HLELRH--------------FAKPG-VKKEKKSKSGND-----------TTLDSSMEMNTTAEGD 399
            ||. ||              ||..| |::.....||..           :...:..|...|...|
Human   441 HLR-RHSGEKPYICEICGKRFAASGDVQRHIIIHSGEKPHLCDICGRGFSNFSNLKEHKKTHTAD 504

  Fly   400 NTVGSDGAGGAGSAGGQSSAT------SGKK----SSSGSSGSGSGAL-----SSSGSVPQVQTV 449
            .....|..|  .|...|....      :|::    |:.|....|||.|     :.:|..|....:
Human   505 KVFTCDECG--KSFNMQRKLVKHRIRHTGERPYSCSACGKCFGGSGDLRRHVRTHTGEKPYTCEI 567

  Fly   450 --------------QSLHTLQGVQVKKDPDAQQQQQQQQQQQQQQQQQA------------MTVS 488
                          :.:|...|   .:.||..::..|..:....::.|:            |.||
Human   568 CNKCFTRSAVLRRHKKMHCKAG---DESPDVLEELSQAIETSDLEKSQSSDSFSQDTSVTLMPVS 629

  Fly   489 GATGGQVQQQVQQVQQQVQQQQQQQQ----QQQQQLQHHQIIDSSGNITTATTSAQAAAAAQQQA 549
                  |:..|..|:..|.:......    :.:..:|.|.:.|..      ..|......|:.|.
Human   630 ------VKLPVHPVENSVAEFDSHSGGSYCKLRSMIQPHGVSDQE------KLSLDPGKLAKPQM 682

  Fly   550 AGQQQQLVAQS--DGSESGAPL 569
            ...|.|..|.|  |....|.||
Human   683 QQTQPQAYAYSDVDTPAGGEPL 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trl	NP_001261846.1	BTB	27..117	CDD:279045	30/121 (25%)
		BTB	35..118	CDD:197585	27/114 (24%)
		GAGA	319..372	CDD:150045	20/74 (27%)
ZBTB49	NP_001317554.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..203		9/46 (20%)
ZBTB49	NP_001317554.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	275..294		4/18 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000