DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trl and NACC2

DIOPT Version :9

Sequence 1:	NP_001261846.1	Gene:	Trl / 2768981	FlyBaseID:	FBgn0013263	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_653254.1	Gene:	NACC2 / 138151	HGNCID:	23846	Length:	587	Species:	Homo sapiens

Alignment Length:	413	Identity:	79/413 - (19%)
Similarity:	139/413 - (33%)	Gaps:	96/413 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 MNSLYSLTWGDYGTSLVSAIQLLRCHGDLVDCTLAAGGRSFPAHKIVLCAASPFLLDLLKNTPCK 69
            |:.:..:...::|.:::..:...|..|...|.::...|::|.||:.||.|:|.:..||.... .|
Human     1 MSQMLHIEIPNFGNTVLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGN-SK 64

  Fly    70 HPVVMLAGVNANDLEALLEFVYRGEVSVDHAQLPSLLQAAQCLNIQGLAPQTVTKDDYTTHSIQL 134
            ....:...|.....:.:|.|.|.|.::         :.|::.|.:.           ||...:|:
Human    65 SAFELPGSVPPACFQQILSFCYTGRLT---------MTASEQLVVM-----------YTAGFLQI 109

  Fly   135 QHMIPQHHDQDQLIATIATAPQQTVHAQVVEDIHHQGQILQATTQTNAAGQQQTIVTTDAAKHDQ 199
            ||::.:..|    :....::|.......|:||...:.|......|..||.....:|:....
Human   110 QHIVERGTD----LMFKVSSPHCDSQTAVIEDAGSEPQSPCNQLQPAAAAAAPYVVSPSVP---- 166

  Fly   200 AVIQAFLPARKR-KPRVKKMSPTAPKISKVEGMDTIMGTPTSSHGSGSVQQVLGENGAEGQLLSS 263
                  :|...| |....::.|..|.::....::|   .|..     .|....|...|.|.....
Human   167 ------IPLLTRVKHEAMELPPAGPGLAPKRPLET---GPRD-----GVAVAAGAAVAAGTAPLK 217

  Fly   264 TPIIKSEGQKVETIVTMDPN-NMIPVTSANAATGEITPAQGATGSSGGNTSGVLSTPKAKRAKHP 327
            .|.:...|  |.::.|:.|. ..:|.            .||...|.|.::   |.|..:..:.|.
Human   218 LPRVSYYG--VPSLATLIPGIQQMPY------------PQGERTSPGASS---LPTTDSPTSYHN 265

  Fly   328 PGTEK--------------------PRSRSQSEQPATCPI----CYAVIRQSRNL---------- 358
            ...|:                    ..|.:..|:|...|:    |..:.|....|
Human   266 EEDEEDDEAYDTMVEEQYGQMYIKASGSYAVQEKPEPVPLESRSCVLIRRDLVALPASLISQIGY 330

  Fly   359 RRHLELRHFAKPGVKKEKKSKSG 381
            |.|.:|.....||.|.|..:.||
Human   331 RCHPKLYSEGDPGEKLELVAGSG 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trl	NP_001261846.1	BTB	27..117	CDD:279045	21/89 (24%)
		BTB	35..118	CDD:197585	19/82 (23%)
		GAGA	319..372	CDD:150045	13/86 (15%)
NACC2	NP_653254.1	BTB	20..120	CDD:279045	27/124 (22%)
		BTB	31..114	CDD:197585	24/103 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..272		9/46 (20%)
		BEN	373..450	CDD:214981
		TIM_phosphate_binding	496..>581	CDD:304361
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	80	1.000	Inparanoid score	I5230
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050