DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trl and Btbd18

DIOPT Version :9

Sequence 1:	NP_001261846.1	Gene:	Trl / 2768981	FlyBaseID:	FBgn0013263	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001138572.1	Gene:	Btbd18 / 100270744	MGIID:	3650217	Length:	723	Species:	Mus musculus

Alignment Length:	430	Identity:	92/430 - (21%)
Similarity:	149/430 - (34%)	Gaps:	99/430 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 IQLLRCH-----GDLVDCTLAAGGRSFPAHKIVLCAASPFLLDLL-KNTPC--KHPVVMLAGVNA 80
            :..|:.|     |...|..|.|.|.:.|||..:|.|.|||..:.| :..|.  :..|:.:.|:..
Mouse    19 VAFLQLHHQQQSGVFCDALLQAEGEAVPAHCCILSACSPFFTERLERERPVQGRKVVLEMGGLKI 83

  Fly    81 NDLEALLEFVYRGEVSVDHAQLPSLLQAAQCLNIQGL------------APQ--TVTKD---DYT 128
            ..|..|::|:|..|:.|...:...:|.||:.|.:..|            |||  .:.::   ...
Mouse    84 QTLRKLVDFLYTSEMEVSQEEAQDVLSAARQLRVSELETLQLEGGKLVKAPQGRRLNRECLQPPA 148

  Fly   129 THSIQLQHMIPQHHDQDQLIATIATAPQQTVHAQVVEDIHHQGQILQATTQTNAAGQQQTIVTTD 193
            ...|..:.:.|:...|..|..|...:|...|.             |::..:...|.::..:...|
Mouse   149 AAPISARVVGPKSRPQTPLPVTQTPSPLGAVR-------------LKSLGEEEGAHKKTNLPNAD 200

  Fly   194 AAKHDQAVIQAFLPARKRKPRV-----KKMSPTA----PKISKVEGMDTIMGTPTSSHGSGSVQQ 249
            :....|.         |:|.||     .:.||::    ||.:|.....|.:   .|.:.|...|.
Mouse   201 SLSDTQL---------KKKARVCLTQESRSSPSSQREGPKETKSNPGPTAL---PSLYPSVDEQL 253

  Fly   250 V-----LGENGAEGQLLSSTPIIKSEGQKVETIVTMDPNNMIPVTSANAATGEIT---PAQGATG 306
            :     |..:.....:.:|||          :.:...|::| |.........:.|   .|||...
Mouse   254 LPRKIRLSRSKPSPHVYTSTP----------SSILSGPSSM-PTAPGRRLWRQRTVSKEAQGVDK 307

  Fly   307 SSGGNTSGVLSTP-------KAKRAKHPPGTEKPRSRSQSE--------QPATCPICYAVIRQSR 356
            ...|....:.|||       .|:..|..|....|.|.|..|        :......|:.|: |..
Mouse   308 QKPGEVRPLQSTPDPSDVGKPAENKKQSPELRAPTSSSVEEGQVGRVKLRKIVNGTCWEVV-QEP 371

  Fly   357 NLRRHLELRHFAKPGVKKEKKSKSGNDTTLDSSMEMNTTA 396
            .||...:.....:|   .:.:..||  |.|.|..|....|
Mouse   372 PLRNTQDSPQILEP---SDVEEPSG--TLLSSVNEQEIPA 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trl	NP_001261846.1	BTB	27..117	CDD:279045	29/97 (30%)
		BTB	35..118	CDD:197585	27/97 (28%)
		GAGA	319..372	CDD:150045	14/67 (21%)
Btbd18	NP_001138572.1	BTB_POZ_BTBD18	20..138	CDD:349602	33/117 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..176		5/25 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	188..350		38/184 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	370..394		5/28 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	603..637
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	699..723
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910