| Sequence 1: | NP_996087.2 | Gene: | ind / 2768974 | FlyBaseID: | FBgn0025776 | Length: | 320 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_079141.2 | Gene: | NANOG / 79923 | HGNCID: | 20857 | Length: | 305 | Species: | Homo sapiens |
| Alignment Length: | 185 | Identity: | 57/185 - (30%) |
|---|---|---|---|
| Similarity: | 76/185 - (41%) | Gaps: | 44/185 - (23%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 129 YPSPPLSANPNSQQLPPIHNLYGSPVVGGLPLPEPGSFCTSPSASSSASLDYTNNFDEPQGKRFK 193
Fly 194 HESSCSPNSSPLKNHSSGGPVEITPLINDYADSSKRIRTAFTSTQLLELEREFSHNAYLSRLRRI 258
Fly 259 EIANRLRLSEKQVKIWFQNRRVKQKKGGSESPTFNLSTNSNGSPQ--ASPVSPQV 311 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| ind | NP_996087.2 | Homeodomain | 228..284 | CDD:459649 | 27/55 (49%) |
| NANOG | NP_079141.2 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..96 | 21/98 (21%) | |
| COG5576 | 74..191 | CDD:227863 | 43/125 (34%) | ||
| Homeodomain | 97..152 | CDD:459649 | 27/54 (50%) | ||
| Required for DNA-binding. /evidence=ECO:0000269|PubMed:25825768 | 122..151 | 15/28 (54%) | |||
| 8 X repeats starting with a Trp in each unit | 196..240 | ||||
| Sufficient for transactivation activity. /evidence=ECO:0000250 | 196..240 | ||||
| Sufficient for strong transactivation activity. /evidence=ECO:0000250 | 241..305 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||