Protein Alignment ind and NKX6-1

DIOPT Version :10

• Sequence 1: NP_996087.2
• Gene: ind / 2768974
• FlyBaseID: FBgn0025776
• Length: 320
• Species: Drosophila melanogaster
• Sequence 2: NP_006159.2
• Gene: NKX6-1 / 4825
• HGNCID: 7839
• Length: 367
• Species: Homo sapiens
• Alignment Length: 309
• Identity: 80/309 - (25%)
• Similarity: 105/309 - (33%)
• Gaps: 111/309 - (35%)

  Fly    14 RPNLSQKKEKLGSPGGSPTAAA-------------AVAAAAMLPSIPMLPYPASYVGSYLFSLGI 65
            :|..:.....||||....:||.             .||:.|.|||       ||..||
Human    73 KPPATGGLSSLGSPPQQLSAATPHGINDILSRPSMPVASGAALPS-------ASPSGS------- 123

  Fly    66 QQQQQQQQQQQQHAAAAAAAAAAAAALQQHPHVSSSPGSLYHPYAQLFASKRKSSGFSNYEGCYP 130
             ............|:|||||||||||      .:|||..|.             :|...:....|
Human   124 -SSSSSSSASASSASAAAAAAAAAAA------AASSPAGLL-------------AGLPRFSSLSP 168

  Fly   131 SPPLSANPNSQQLPPIHNLYGSP------VVGGLPLP-----------EPGSFCTSPSASSSASL 178
            .||          ||  .||.||      .||..|.|           .||...:.|...:
Human   169 PPP----------PP--GLYFSPSAAAVAAVGRYPKPLAELPGRTPIFWPGVMQSPPWRDA---- 217

  Fly   179 DYTNNFDEPQGKRFKHESSCSPNSSPLKNHSSGGPVEITPLINDYADSSKRIRTAFTSTQLLELE 243
                            ..:|:|:..              .::.|.....|..|..|:..|:..||
Human   218 ----------------RLACTPHQG--------------SILLDKDGKRKHTRPTFSGQQIFALE 252

  Fly   244 REFSHNAYLSRLRRIEIANRLRLSEKQVKIWFQNRRVK-QKKGGSESPT 291
            :.|....||:...|..:|..|.::|.|||:||||||.| :||..:|..|
Human   253 KTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMAT 301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ind	NP_996087.2	Homeodomain	228..284	CDD:459649	23/56 (41%)
NKX6-1	NP_006159.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..133		17/74 (23%)
		Repressor domain. /evidence=ECO:0000250	102..268		56/245 (23%)
		Homeodomain	235..293	CDD:459649	23/57 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	294..367		3/8 (38%)
		Involved in DNA-binding. /evidence=ECO:0000250	306..367