Protein Alignment ind and PDX1

DIOPT Version :10

• Sequence 1: NP_996087.2
• Gene: ind / 2768974
• FlyBaseID: FBgn0025776
• Length: 320
• Species: Drosophila melanogaster
• Sequence 2: NP_000200.1
• Gene: PDX1 / 3651
• HGNCID: 6107
• Length: 283
• Species: Homo sapiens
• Alignment Length: 263
• Identity: 82/263 - (31%)
• Similarity: 110/263 - (41%)
• Gaps: 51/263 - (19%)

  Fly    74 QQQQHAAAAAAAAAAAAALQQHPHVSSS-PGSLY----------HPYAQLFASKRKSS--GFSNY 125
            ::|.:||........|......|..|:| |..||          ||:.....:..:.|  ..|.|
Human     4 EEQYYAATQLYKDPCAFQRGPAPEFSASPPACLYMGRQPPPPPPHPFPGALGALEQGSPPDISPY 68

  Fly   126 EGCYPSPPLSANPNSQQLPPIHNLYGSPVVGGLPLPEPGSFCTSPSASSSASLDYTNNFDEPQGK 190
            |    .|||:.:|....|.  |:|   |....||.|..|.|   |..:....|:..|....|
Human    69 E----VPPLADDPAVAHLH--HHL---PAQLALPHPPAGPF---PEGAEPGVLEEPNRVQLP--- 118

  Fly   191 RFKHESSCSPNSSPLKNHSSGGPVEITPLINDYADSSKRIRTAFTSTQLLELEREFSHNAYLSRL 255
             |....|...::  .|...:||.....|      :.:||.|||:|..||||||:||..|.|:||.
Human   119 -FPWMKSTKAHA--WKGQWAGGAYAAEP------EENKRTRTAYTRAQLLELEKEFLFNKYISRP 174

  Fly   256 RRIEIANRLRLSEKQVKIWFQNRRVKQKK--------------GGSESPTFNLSTNSNGSPQASP 306
            ||:|:|..|.|:|:.:||||||||:|.||              ||...|..:.:..|.....|.|
Human   175 RRVELAVMLNLTERHIKIWFQNRRMKWKKEEDKKRGGGTAVGGGGVAEPEQDCAVTSGEELLALP 239

  Fly   307 VSP 309
            ..|
Human   240 PPP 242

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ind	NP_996087.2	Homeodomain	228..284	CDD:459649	34/55 (62%)
PDX1	NP_000200.1	Transactivation domain. /evidence=ECO:0000250	13..73		14/63 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..71		8/40 (20%)
		Antp-type hexapeptide	118..123		2/8 (25%)
		Homeodomain	147..203	CDD:459649	34/55 (62%)
		Nuclear localization signal. /evidence=ECO:0000250	197..203		3/5 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..283		9/42 (21%)