DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ind and PDX1

DIOPT Version :9

Sequence 1:NP_996087.2 Gene:ind / 2768974 FlyBaseID:FBgn0025776 Length:320 Species:Drosophila melanogaster
Sequence 2:NP_000200.1 Gene:PDX1 / 3651 HGNCID:6107 Length:283 Species:Homo sapiens


Alignment Length:263 Identity:82/263 - (31%)
Similarity:110/263 - (41%) Gaps:51/263 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 QQQQHAAAAAAAAAAAAALQQHPHVSSS-PGSLY----------HPYAQLFASKRKSS--GFSNY 125
            ::|.:||........|......|..|:| |..||          ||:.....:..:.|  ..|.|
Human     4 EEQYYAATQLYKDPCAFQRGPAPEFSASPPACLYMGRQPPPPPPHPFPGALGALEQGSPPDISPY 68

  Fly   126 EGCYPSPPLSANPNSQQLPPIHNLYGSPVVGGLPLPEPGSFCTSPSASSSASLDYTNNFDEPQGK 190
            |    .|||:.:|....|.  |:|   |....||.|..|.|   |..:....|:..|....|   
Human    69 E----VPPLADDPAVAHLH--HHL---PAQLALPHPPAGPF---PEGAEPGVLEEPNRVQLP--- 118

  Fly   191 RFKHESSCSPNSSPLKNHSSGGPVEITPLINDYADSSKRIRTAFTSTQLLELEREFSHNAYLSRL 255
             |....|...::  .|...:||.....|      :.:||.|||:|..||||||:||..|.|:||.
Human   119 -FPWMKSTKAHA--WKGQWAGGAYAAEP------EENKRTRTAYTRAQLLELEKEFLFNKYISRP 174

  Fly   256 RRIEIANRLRLSEKQVKIWFQNRRVKQKK--------------GGSESPTFNLSTNSNGSPQASP 306
            ||:|:|..|.|:|:.:||||||||:|.||              ||...|..:.:..|.....|.|
Human   175 RRVELAVMLNLTERHIKIWFQNRRMKWKKEEDKKRGGGTAVGGGGVAEPEQDCAVTSGEELLALP 239

  Fly   307 VSP 309
            ..|
Human   240 PPP 242

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
indNP_996087.2 Homeobox 231..283 CDD:278475 32/51 (63%)
PDX1NP_000200.1 Transactivation domain. /evidence=ECO:0000250 13..73 14/63 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 34..71 8/40 (20%)
Antp-type hexapeptide 118..123 2/8 (25%)
Homeobox 149..202 CDD:278475 32/52 (62%)
Nuclear localization signal. /evidence=ECO:0000250 197..203 3/5 (60%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 201..283 9/42 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0489
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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