Protein Alignment ind and NOTO

DIOPT Version :10

• Sequence 1: NP_996087.2
• Gene: ind / 2768974
• FlyBaseID: FBgn0025776
• Length: 320
• Species: Drosophila melanogaster
• Sequence 2: NP_001127934.1
• Gene: NOTO / 344022
• HGNCID: 31839
• Length: 251
• Species: Homo sapiens
• Alignment Length: 231
• Identity: 62/231 - (26%)
• Similarity: 90/231 - (38%)
• Gaps: 66/231 - (28%)

  Fly   127 GCYPSPPLSANPNSQQLPPIHNLYGSP--VVGGLPLPEP---------GSFCTSPSASSSASLDY 180
            |..|:|.....||:.:.|   ..:.||  |...|..|:|         ||.|..|:..::|||..
Human    25 GRSPAPRSPTGPNTPRAP---GRFESPFSVEAILARPDPCAPAASQPSGSACVHPAFWTAASLCA 86

  Fly   181 TNN------------------FDEPQGKRFKHESSCSPNSSPLKN------------HSSG---- 211
            |..                  :..|           .|..:|:..            |.||
Human    87 TGGLPWACPTSWLPAYLSVGFYPVP-----------GPRVAPVCGLLGFGVTGLELAHCSGLWAF 140

  Fly   212 ---GPVEITPLINDYADSSKRIRTAFTSTQLLELEREFSHNAYLSRLRRIEIANRLRLSEKQVKI 273
               .|.|.   :.|.....||:||.|...||.|||:.|:....|...:|.::|.||:|:|.||::
Human   141 PDWAPTED---LQDTERQQKRVRTMFNLEQLEELEKVFAKQHNLVGKKRAQLAARLKLTENQVRV 202

  Fly   274 WFQNRRVK-QKKGGSESPTFNLSTNSNGSPQASPVS 308
            |||||||| ||:....:...:....|...|.:|.::
Human   203 WFQNRRVKYQKQQKLRAAVTSAEAASLDEPSSSSIA 238

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ind	NP_996087.2	Homeodomain	228..284	CDD:459649	29/56 (52%)
NOTO	NP_001127934.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..47		6/24 (25%)
		PHA03247	<16..120	CDD:223021	23/108 (21%)
		Homeodomain	157..213	CDD:459649	28/55 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	224..251		3/15 (20%)