DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ind and HOXD3

DIOPT Version :9

Sequence 1:	NP_996087.2	Gene:	ind / 2768974	FlyBaseID:	FBgn0025776	Length:	320	Species:	Drosophila melanogaster
Sequence 2:	NP_008829.3	Gene:	HOXD3 / 3232	HGNCID:	5137	Length:	432	Species:	Homo sapiens

Alignment Length:	277	Identity:	89/277 - (32%)
Similarity:	123/277 - (44%)	Gaps:	64/277 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 SIPMLPYPASYVGSYLFSLGIQQQQQQQQQQQQHAAAAAAAAAAAAALQQHPHVSSS-PGSLYHP 108
            |.|..|||.....|.|               ......:|.:..::|.|:...|..:. .||...|
Human    44 STPHQPYPPPAAASSL---------------DTDYPGSACSIQSSAPLRAPAHKGAELNGSCMRP 93

  Fly   109 YAQLFASKRKSSGFS-----NYEGCYPSPPLSANPNSQQLPPIHNLYGSPV--VGGLPLPEPGSF 166
            ..   .:.:...|.|     |.|...|.||    |....|||     .||.  .||:|..:|..
Human    94 GT---GNSQGGGGGSQPPGLNSEQQPPQPP----PPPPTLPP-----SSPTNPGGGVPAKKPKG- 145

  Fly   167 CTSPSASSSASLDYTNNFD--EPQGKRFKHESSCSPNSSPLKNHSSGGPVEITPLINDYADSSKR 229
              .|:||||::......|.  :...:..|.::||:......::.|..||            :|||
Human   146 --GPNASSSSATISKQIFPWMKESRQNSKQKNSCATAGESCEDKSPPGP------------ASKR 196

  Fly   230 IRTAFTSTQLLELEREFSHNAYLSRLRRIEIANRLRLSEKQVKIWFQNRRVKQK-----KGGSES 289
            :|||:||.||:|||:||..|.||.|.||:|:||.|.|:|:|:||||||||:|.|     ||...|
Human   197 VRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKAKGILHS 261

  Fly   290 PTFNLSTNSNGSPQASP 306
            |       ::.||:.||
Human   262 P-------ASQSPERSP 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ind	NP_996087.2	Homeobox	231..283	CDD:278475	34/51 (67%)
HOXD3	NP_008829.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..62		7/32 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	68..197		37/155 (24%)
		Antp-type hexapeptide	160..165		1/4 (25%)
		Homeobox	198..250	CDD:306543	34/51 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	253..280		8/26 (31%)
		DUF4074	369..430	CDD:315871
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..432
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810