Protein Alignment ind and HHEX

DIOPT Version :10

• Sequence 1: NP_996087.2
• Gene: ind / 2768974
• FlyBaseID: FBgn0025776
• Length: 320
• Species: Drosophila melanogaster
• Sequence 2: NP_002720.1
• Gene: HHEX / 3087
• HGNCID: 4901
• Length: 270
• Species: Homo sapiens
• Alignment Length: 240
• Identity: 63/240 - (26%)
• Similarity: 92/240 - (38%)
• Gaps: 78/240 - (32%)

  Fly    94 QHPHVSSSPGSLYHPYAQLFASKRKSSGFSNYEGCYPSPPLSANPNSQQLPPIH--NLYGSPVVG 156
            |:||...:.|::..|   |:|               |:|         .|.|.|  ..|...::|
Human     2 QYPHPGPAAGAVGVP---LYA---------------PTP---------LLQPAHPTPFYIEDILG 39

  Fly   157 -GLPLPEPGSFCTSPSAS-SSASLDYTNNFDEPQGKRFKHESSCSPNSSPLKNHSS--------- 210
             |...|.|.....||::| :|....|.....||           :|......:||:
Human    40 RGPAAPTPAPTLPSPNSSFTSLVSPYRTPVYEP-----------TPIHPAFSHHSAAALAAAYGP 93

  Fly   211 ---GGPVEITP-LINDYADS-----------------------SKRIRTAFTSTQLLELEREFSH 248
               |||:...| .:|||..:                       .|..:..|::.|.:|||::|..
Human    94 GGFGGPLYPFPRTVNDYTHALLRHDPLGKPLLWSPFLQRPLHKRKGGQVRFSNDQTIELEKKFET 158

  Fly   249 NAYLSRLRRIEIANRLRLSEKQVKIWFQNRRVKQKKGGSESPTFN 293
            ..|||...|..:|..|:|||:|||.||||||.|.::...|:|..|
Human   159 QKYLSPPERKRLAKMLQLSERQVKTWFQNRRAKWRRLKQENPQSN 203

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ind	NP_996087.2	Homeodomain	228..284	CDD:459649	26/55 (47%)
HHEX	NP_002720.1	Interaction with SOX13. /evidence=ECO:0000269|PubMed:20028982	1..137		34/172 (20%)
		Homeodomain	136..194	CDD:459649	26/57 (46%)
		Required for WNT signaling induction. /evidence=ECO:0000269|PubMed:20028982	137..270		29/67 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	194..270		3/10 (30%)