DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ind and hoxb3a

DIOPT Version :9

Sequence 1:	NP_996087.2	Gene:	ind / 2768974	FlyBaseID:	FBgn0025776	Length:	320	Species:	Drosophila melanogaster
Sequence 2:	NP_571192.2	Gene:	hoxb3a / 30339	ZFINID:	ZDB-GENE-990415-104	Length:	417	Species:	Danio rerio

Alignment Length:	280	Identity:	89/280 - (31%)
Similarity:	127/280 - (45%)	Gaps:	60/280 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 SYVGSYLFSL-----GIQQQQQQQQQQQQHAAAAAAAAAAAAALQQHPHVSSSPGSL-------- 105
            ||.|:..|..     ..|.....:...|:.|.:..:...:|....||.......||.
Zfish    17 SYQGANGFGYDAPAPAFQNSAHLEGDYQRSACSLQSLGTSAPPQPQHAKTKELNGSCMRPSLPPE 81

  Fly   106 YHPYAQLFASKRKSSGFSNYEGCYPSPPLS----ANPNSQQLPPIHNLYGSPVVGGLPLPEPGSF 166
            :||..|:                  |||.:    |..|:.|.|      |....||:    .||.
Zfish    82 HHPPPQV------------------SPPQNTVNVAATNATQQP------GGSGGGGV----AGSG 118

  Fly   167 CTSPSASSSASLDYTNNFDE------PQGKRFKHESSCSPNSSPLKNHSSGGPVEITPLINDYAD 225
            .||.|:|.|:|:.......:      .:.::...:.:.||::|.....||||  |.:|   ..:.
Zfish   119 GTSKSSSKSSSMATNPTLTKQIFPWMKESRQNTKQKNSSPSASSANAESSGG--EKSP---PGSA 178

  Fly   226 SSKRIRTAFTSTQLLELEREFSHNAYLSRLRRIEIANRLRLSEKQVKIWFQNRRVKQKKGGSESP 290
            :|||.|||:||.||:|||:||..|.||.|.||:|:||.|.|||:|:||||||||:|.||   :..
Zfish   179 ASKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLSERQIKIWFQNRRMKYKK---DQK 240

  Fly   291 TFNLSTNSNG-SPQASPVSP 309
            :..:.::|.| ||..||..|
Zfish   241 SKGIGSSSGGPSPTGSPPLP 260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ind	NP_996087.2	Homeobox	231..283	CDD:278475	35/51 (69%)
hoxb3a	NP_571192.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..135		26/111 (23%)
		Antp-type hexapeptide	140..145		0/4 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..184		12/41 (29%)
		Homeobox	184..236	CDD:278475	35/51 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	237..290		8/27 (30%)
		DUF4074	353..415	CDD:290032
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..417
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810