DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ind and Pdx1

DIOPT Version :9

Sequence 1:	NP_996087.2	Gene:	ind / 2768974	FlyBaseID:	FBgn0025776	Length:	320	Species:	Drosophila melanogaster
Sequence 2:	NP_074043.4	Gene:	Pdx1 / 29535	RGDID:	62387	Length:	283	Species:	Rattus norvegicus

Alignment Length:	195	Identity:	68/195 - (34%)
Similarity:	90/195 - (46%)	Gaps:	34/195 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 YPSPPLSANPNSQQLPPIHNLYGSPVVGGLPLPEPGSFCTSPSASSSASLDYTNNFDEPQGKRFK 193
            |..|||:.:|....|.  |:|   |...||..|.||.|   |:.:.      |...:||......
  Rat    68 YEVPPLADDPAGAHLH--HHL---PAQLGLAHPPPGPF---PNGTE------TGGLEEPSRVHLP 118

  Fly   194 HESSCSPNSSPLKNHSSGGPVEITPLINDYADSSKRIRTAFTSTQLLELEREFSHNAYLSRLRRI 258
            .....|..:...|:..:||.....|      :.:||.|||:|..||||||:||..|.|:||.||:
  Rat   119 FPWMKSTKAHAWKSQWAGGAYAAEP------EENKRTRTAYTRAQLLELEKEFLFNKYISRPRRV 177

  Fly   259 EIANRLRLSEKQVKIWFQNRRVKQKK--------------GGSESPTFNLSTNSNGSPQASPVSP 309
            |:|..|.|:|:.:||||||||:|.||              ||.|.|..:.:..|.....|.|..|
  Rat   178 ELAVMLNLTERHIKIWFQNRRMKWKKEEDKKRSSGTTSGGGGGEEPEQDCAVTSGEELLALPPPP 242

Fly 310 309
Rat 243 242

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ind	NP_996087.2	Homeobox	231..283	CDD:278475	32/51 (63%)
Pdx1	NP_074043.4	Transactivation domain	13..73		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..81		5/12 (42%)
		Antp-type hexapeptide	118..123		0/4 (0%)
		Homeobox	149..203	CDD:395001	32/53 (60%)
		Nuclear localization signal. /evidence=ECO:0000250	197..203		3/5 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..283		10/42 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810