DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rpn12R and RPN12

DIOPT Version :9

Sequence 1:	NP_996086.1	Gene:	Rpn12R / 2768973	FlyBaseID:	FBgn0036465	Length:	262	Species:	Drosophila melanogaster
Sequence 2:	NP_116710.1	Gene:	RPN12 / 850613	SGDID:	S000001948	Length:	274	Species:	Saccharomyces cerevisiae

Alignment Length:	261	Identity:	76/261 - (29%)
Similarity:	119/261 - (45%)	Gaps:	29/261 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 CSRLLDGFKLELVRSNFGTIQTASSSKQKD----QLIKSREMLEIAVEHSITIKDYAAFERYMAQ 82
            |.:||...|:||:::|   :.....|.|.|    .|:.::.:||:....||...::.:||.|..|
Yeast    23 CEKLLPPIKIELIKNN---LLIPDLSIQNDIYLNDLMITKRILEVGALASIQTFNFDSFENYFNQ 84

  Fly    83 LNTYYYDYDKYLESSKHMYKFMGLNLLYMLATNRLADFHIELERLPTAL--LLHDSFIQPVLALE 145
            |..||:..:..|..|....|.:.|.||.:|:.|....||.||:.|...:  |..||.:...:.|:
Yeast    85 LKPYYFSNNHKLSESDKKSKLISLYLLNLLSQNNTTKFHSELQYLDKHIKNLEDDSLLSYPIKLD 149

  Fly   146 NYYMEGRYNK---ILQAKKSMPSEIYSNFMDILVNTAREEIASCMEKSYLKMAPKLAAQRLGLRP 207
            .:.|||.|.|   :||:.....|| :.:|.|||.:..|:|||...|.|| ...|....:.|....
Yeast   150 RWLMEGSYQKAWDLLQSGSQNISE-FDSFTDILKSAIRDEIAKNTELSY-DFLPLSNIKALLFFN 212

  Fly   208 GSKELFELATKRQWCL-----------DEEGNYDYAGLHTRPMEKVPAKDIATHNLTYAQELEKI 261
            ..||..:.|.:|.|.:           .|:.:|:...:|    |:....:|....:.||..:|.|
Yeast   213 NEKETEKFALERNWPIVNSKVYFNNQSKEKADYEDEMMH----EEDQKTNIIEKAMDYAISIENI 273

  Fly   262 V 262
            |
Yeast   274 V 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpn12R	NP_996086.1	CSN8_PSD8_EIF3K	98..228	CDD:287089	43/145 (30%)
RPN12	NP_116710.1	CSN8_PSD8_EIF3K	122..226	CDD:420155	35/105 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343097
Domainoid	1	1.000	62	1.000	Domainoid score	I2489
eggNOG	1	0.900	-	-		E1_KOG3151
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1465
Isobase	1	0.950	-	0	Normalized mean entropy	S2152
OMA	1	1.010	-	-		QHG53806
OrthoFinder	1	1.000	-	-		FOG0003512
OrthoInspector	1	1.000	-	-		otm46610
orthoMCL	1	0.900	-	-		OOG6_102164
Panther	1	1.100	-	-	O	PTHR12387
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1201
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.740