DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rpn12R and PSMD8

DIOPT Version :9

Sequence 1:	NP_996086.1	Gene:	Rpn12R / 2768973	FlyBaseID:	FBgn0036465	Length:	262	Species:	Drosophila melanogaster
Sequence 2:	NP_002803.2	Gene:	PSMD8 / 5714	HGNCID:	9566	Length:	350	Species:	Homo sapiens

Alignment Length:	262	Identity:	108/262 - (41%)
Similarity:	166/262 - (63%)	Gaps:	4/262 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SNLYTELKNEWSKHAPNLTHCSRLLDGFKLELVRSNFGTIQTASSSKQKDQLIKSREMLEIAVEH 66
            :.:|.:||.||::.:|||:.|...|...||.|:..||  :.|..:...|.|||.:|::|||..:.
Human    92 TGMYEQLKGEWNRKSPNLSKCGEELGRLKLVLLELNF--LPTTGTKLTKQQLILARDILEIGAQW 154

  Fly    67 SITIKDYAAFERYMAQLNTYYYDYDKYLESSKHMYKFMGLNLLYMLATNRLADFHIELERLPTAL 131
            ||..||..:||||||||..||:||.:.|..|.:|::.:|||||::|:.||:|:||.||||||...
Human   155 SILRKDIPSFERYMAQLKCYYFDYKEQLPESAYMHQLLGLNLLFLLSQNRVAEFHTELERLPAKD 219

  Fly   132 LLHDSFIQPVLALENYYMEGRYNKILQAKKSMPSEIYSNFMDILVNTAREEIASCMEKSYLKMAP 196
            :..:.:|:..::||.|.|||.|||:..||.::|:|.|:.|:|||::|.|:|||.|:||:|.|:.
Human   220 IQTNVYIKHPVSLEQYLMEGSYNKVFLAKGNIPAESYTFFIDILLDTIRDEIAGCIEKAYEKIL- 283

  Fly   197 KLAAQRLGLRPGSKELFELATKRQWCLDEEGNYDYAGLHTRPME-KVPAKDIATHNLTYAQELEK 260
            ...|.|:......|::.:.|.||.|.|.....|.:|....:|.: .:|:.::|...:.||::||.
Human   284 FTEATRILFFNTPKKMTDYAKKRGWVLGPNNYYSFASQQQKPEDTTIPSTELAKQVIEYARQLEM 348

  Fly   261 IV 262
            ||
Human   349 IV 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpn12R	NP_996086.1	CSN8_PSD8_EIF3K	98..228	CDD:287089	55/129 (43%)
PSMD8	NP_002803.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
PSMD8	NP_002803.2	CSN8_PSD8_EIF3K	201..315	CDD:370807	48/114 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144953
Domainoid	1	1.000	83	1.000	Domainoid score	I8350
eggNOG	1	0.900	-	-		E1_KOG3151
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2152
OMA	1	1.010	-	-		QHG53806
OrthoDB	1	1.010	-	-		D1183195at2759
OrthoFinder	1	1.000	-	-		FOG0003512
OrthoInspector	1	1.000	-	-		otm40647
orthoMCL	1	0.900	-	-		OOG6_102164
Panther	1	1.100	-	-	O	PTHR12387
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1201
SonicParanoid	1	1.000	-	-		X2884
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.700