DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33490 and efhb

DIOPT Version :9

Sequence 1:	NP_996047.1	Gene:	CG33490 / 2768970	FlyBaseID:	FBgn0053490	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001188418.1	Gene:	efhb / 571184	ZFINID:	ZDB-GENE-091001-1	Length:	585	Species:	Danio rerio

Alignment Length:	606	Identity:	140/606 - (23%)
Similarity:	232/606 - (38%)	Gaps:	125/606 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IERN----------PGIRAAGLTSTVQFNGAKDCLFVVSLEEEAEDRIRALCRRSRPKPAK---- 58
            ||||          |.|||||....:. :..|.||..::........:|......||....
Zfish     4 IERNSSTRRRRDAFPSIRAAGKLIPIG-DRTKSCLQEITPRTVTPPMVRKFVHSLRPPVGSVRVF 67

  Fly    59 ----RTPKLPT---HQI--------GDILNNENPGLFAELQNKFRE--NMFHKKPGLGEAR-ETN 105
                ..|.:.|   |.:        |.::|......|.|...:.:|  :..::|..||.:: :..
Zfish    68 HGRANDPDIATTLVHGVNTISSINAGSVINPAPKTRFQERLRQLQEISHATNQKAPLGRSQVQGP 132

  Fly   106 SKPSYVTNLSHTFGKITQSNCNDSLYSIVLPPKSAEQVNREYGEYHDKHIISHNHYFPAEQINRR 170
            ..||::.....|||..|.  |..:...::.|||:|::|.||.||.|..:|.||..||..|.::|:
Zfish   133 GLPSWLNPEKTTFGVTTL--CFSNGGEVINPPKTADEVKREAGEGHQLYIRSHGSYFVGEHVDRK 195

  Fly   171 YS-KPFNRFNTFGLPPTLDPSGIKMKHCLEEGEEHL-----KIVKKPQKDIDDRTKGPLGKKYSW 229
            |: ..:.|.:.||:|......|..:..||....:.|     |:|.|...|..::....:||.:.
Zfish   196 YNWSHYARESRFGVPTPHYNDGRNISKCLHWPCDSLMHNSAKLVPKRCDDFREKPHPQIGKVHD- 259

  Fly   230 YP----YQIPENMTFGRTL-PRETDVRSLLEYTSPS--IKSEKLAIAVSHLNMLRKMLQERDDFN 287
             |    ..:|.:.|||..: |.......||..|.|.  :|.::...|:  ::.:|:.|::.:...
Zfish   260 -PIAETLNVPSDHTFGVLMKPDSFGAVDLLYQTPPGEYLKGKERQRAL--VSAVRQHLKKSNYQK 321

  Fly   288 MNQVISALGKKDTEGQRQLPLDEVINVLHKLSIPADAEKIRNAASHFQLFVDEGCCSEKVKYEEL 352
            .:.::.|....|.:|            |.|:    |.|.:|.|...|.:.:.:....|.:.|
Zfish   322 FSSLLEAFRYYDKKG------------LGKI----DKEDLREACHQFNMIISDPLLDELMDY--- 367

  Fly   353 CD-----LLSILKSLPLIGSITPMPKVTYNQD--TAYR-QLCADLMKKPPEGPQFKTAKKASIKQ 409
            ||     |:..::....:.....||.....||  |..| ...|.........|:..|.|.....:
Zfish   368 CDVHKDGLIDFVEFSNFLNWKDKMPISRMEQDILTGERVAWTAPANMHRTHLPESSTVKPLVKPE 432

  Fly   410 DMNAAPFKDFNSPQKAPIEQDMDETRSRDYKTSQK-------------------TPIQQDM---- 451
            |:.  |.:: .|.:|.|.......|...|:.||..                   ..|:.|:
Zfish   433 DLE--PVEE-GSTKKTPKTLSRPRTAQSDFITSNSLINAVVGGLSTSNYHTYGVPSIRADLPAPR 494

  Fly   452 -----DDTRVG------DVINPEFSTLCGLWPSDFKALRSKDEIERIFKDI---VSKEDFQTIW- 501
                 |.|..|      |:::|...:|.|:...:|.:.|:|:||.:||:.:   .:.|.|:..|
Zfish   495 IKSISDRTNYGDQATARDLLHPPLHSLYGVHEQEFFSPRTKEEIAQIFQKVGLNTADEMFEEAWR 559

  Fly   502 -LSLMDEQKDQNEMASVAQFR 521
             .|:.|...|    .||..||
Zfish   560 LASMRDPDGD----VSVESFR 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33490	NP_996047.1	None
efhb	NP_001188418.1	EF-hand_7	325..385	CDD:290234	15/78 (19%)
efhb	NP_001188418.1	EFh	325..381	CDD:238008	15/74 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CJU2
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	95	1.000	Inparanoid score	I5047
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1016066at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto40319
orthoMCL	1	0.900	-	-		OOG6_104929
Panther	1	1.100	-	-	O	PTHR12086
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.830