DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33490 and Efhb

DIOPT Version :9

Sequence 1:	NP_996047.1	Gene:	CG33490 / 2768970	FlyBaseID:	FBgn0053490	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001100349.1	Gene:	Efhb / 301168	RGDID:	1566407	Length:	852	Species:	Rattus norvegicus

Alignment Length:	606	Identity:	139/606 - (22%)
Similarity:	230/606 - (37%)	Gaps:	143/606 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GRYIERNPGIRAAGLTSTVQFNGAKDCLFVVSLEEEAEDRIRALCRRSRPKPAKR---------- 59
            |::.:|.|....||....|.:..| :||            ...|.|...|..||:
  Rat   271 GKFFDRAPSWPTAGKVKPVGYRVA-NCL------------TEKLPRLMTPPEAKKYFNFRYPPPG 322

  Fly    60 ----------TPKLP---TH--------QIGDILNNENPGLFAELQNKFRENMF--HKKPGLGEA 101
                      .|::.   ||        .:..::|.:....|.:.....:|:::  |::..||::
  Rat   323 AERIFYGRANDPQIAPYLTHGMRPKGLVTMSSLINPQPITTFQQKVKDKKESIYFSHQRAPLGKS 387

  Fly   102 R-ETNSKPSYVTNLSHTFGKITQSNCNDSLYSIVLPPKSAEQVNREYGEYHDKHIISHNHYFPAE 165
            . :|...|..:..::.|.|..|....  |:..:|.|.||.|.|.:|..|.||.:.||||.||..|
  Rat   388 HDQTPGLPKGMDVINTTLGTPTIREL--SVRDVVNPSKSFEDVFKEGQEGHDLYTISHNDYFAGE 450

  Fly   166 QINRRYS-KPFNRFNTFGLPPTLDPSG---IKMKHCLEE--GEEHLKIVKKPQKDIDDRTKGPLG 224
            ..||:|: ..|:|||.:|:|......|   .|..|.|.|  .|...|||.|...|.:::.:..||
  Rat   451 AKNRKYNPASFHRFNLYGVPTPHCNDGRTMAKTLHWLHELQMERGAKIVSKRADDFEEKFQHRLG 515

  Fly   225 KKYSWYP----YQIPENMTFGRTL-PRETDVRSLLEYTSPSI----KSEKLAIAVSHLNMLRKML 280
            :...  |    ..:|...|||..| |.|.....|:.|..|..    |..:.|:..:..:.|:|..
  Rat   516 RVLD--PIAETMNVPPGHTFGACLQPEEYGAGDLIHYRGPDEYLRGKDRQRALVAAARHHLKKFN 578

  Fly   281 QERDDFNMNQVISALGKKDTEGQRQLPLDEVIN--VLHKLSIPADAEKIRNAASHFQLFVD---E 340
            .:..|    .::.|....|.:|      |.||:  .||:..:.|:....:....|...:.|   :
  Rat   579 HQHFD----TLLMAFRHYDKKG------DGVIDRAELHEACVQANLHLDKMLLDHLFDYCDVDQD 633

  Fly   341 GCCSEKVKYEELCDLLSILKSLPLI---------GSITPMPKVTYNQ-----DTAYRQLCADLMK 391
            |.    :.|.|..:.|:....:||.         |..|....||...     |.:......|::.
  Rat   634 GL----INYLEFANFLTWKDRIPLTEYEKRVVIKGKKTDCENVTETSIVGETDPSLLVNPEDIVP 694

  Fly   392 KPP----------------EGPQFKTAKKASIKQDMNAAP---FKDFNSPQKAPIEQDMDETRSR 437
            |.|                ...|:||. .:.|...:.|.|   :..:..|   .|..|:...|
  Rat   695 KEPGSSEEIVRTILRPGDKVSDQYKTT-SSEINAVVGAVPSICYPIYGVP---TIRSDIPAPR-- 753

  Fly   438 DYKTSQKTPIQQDMDDTRVGD------VINPEFSTLCGLWPSDFKALRSKDEIERIFKDI---VS 493
                     |::..|....|:      :::|...:..|::..||...|||:||..|..:|   ::
  Rat   754 ---------IRRVSDMNNYGEEGNAYALLHPSIFSQKGVFERDFFKTRSKEEISDILTNIGVKLT 809

  Fly   494 KEDFQTIWLSLMDEQKDQNEM 514
            :|:|:.:| :|..::..|.|:
  Rat   810 EEEFENVW-NLASQKHQQGEV 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33490	NP_996047.1	None
Efhb	NP_001100349.1	EFh	585..646	CDD:238008	14/70 (20%)
Efhb	NP_001100349.1	EF-hand_7	585..645	CDD:290234	14/69 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CJU2
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	78	1.000	Inparanoid score	I5140
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1016066at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto96216
orthoMCL	1	0.900	-	-		OOG6_104929
Panther	1	1.100	-	-	O	PTHR12086
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.830