DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33490 and efhb

DIOPT Version :9

Sequence 1:	NP_996047.1	Gene:	CG33490 / 2768970	FlyBaseID:	FBgn0053490	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001188396.1	Gene:	efhb / 100490241	XenbaseID:	XB-GENE-6035362	Length:	582	Species:	Xenopus tropicalis

Alignment Length:	616	Identity:	130/616 - (21%)
Similarity:	236/616 - (38%)	Gaps:	132/616 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MANI--GRYIERNPGIRAAGLTSTVQFNGAKDCLFVVSLEEEAEDRIRALCRRSRPKPA------ 57
            :|:|  ||:|:|:|.||:||....|. ..|..||..:.........::......||.|.
Frog     4 LASIYQGRFIDRSPSIRSAGKLFPVG-ERAASCLVEIHPRTNTPPVVQKFLNTRRPNPGARRLFY 67

  Fly    58 -----KRTPKLPTHQI--------GDILNNENPGLFAELQNKFRENMF--HKKPGLG-EARETNS 106
                 .|.....||.:        |.::|......|....|..:|.::  |::..|| :..:|.:
Frog    68 GKANDSRVEDYVTHGVSTRPSLSAGALINLPPKTFFQHRLNDRKEAIYTSHQQRPLGKQPDQTKA 132

  Fly   107 KPSYVTNLSHTFGKITQSNCNDSLYSIVLPPKSAEQVNREYGEYHDKHIISHNHYFPAEQINRRY 171
            .|:.:.....|||:  :|..:.|..:|:.||||.:::..|..:.|..::::||.|...|..:|:|
Frog   133 LPATIDLNEMTFGQ--KSKRDISASTIINPPKSFQELKEESQKGHQLYVVTHNDYDVGEPKDRKY 195

  Fly   172 S-KPFNRFNTFGLPPTLDPSGIKMKHCLE-----EGEEHLKIVKKPQKDIDDRTKGPLGKKYSWY 230
            . ..:.:...||:.......|..:...|.     :.:|...||.|...|..:|.:..|||...
Frog   196 DCTTYRKNKRFGIETPHFNDGRHVARSLRWLYETKMKERANIVPKGVDDFRERFQHQLGKVCD-- 258

  Fly   231 P----YQIPENMTFGRTLPRETD---VRSLLEYTSP------SIKSEKLAIAVSHLNMLRKMLQE 282
            |    .::|.:.|||  :|.:.:   |:..|::|:.      |.|...:..||      .:..:.
Frog   259 PIADTMKVPPDHTFG--IPTQHEKYGVKDALDFTTAKNFLCGSDKHRAIRAAV------HQHFKS 315

  Fly   283 RDDFNMNQVISALGKKDTEGQRQLPLDEVINVLHKLSI--------------PADAEKIRNAASH 333
            .:..|...::.|....|..|..::..:|:.:...:..:              ..|.:.:.|.|.
Frog   316 TNYENFGLLLEAFRYYDKNGIGKITKEELKSTCVQFGLDLHIDLFEFILQYCEVDKDGLINFAD- 379

  Fly   334 FQLFVDEGCCSEKVKYEELCDLLSILKSLPLIGSITPMPKVTYNQDTAYRQLCADLMKKPPEGPQ 398
            |..||:   ..:|:..|||.:.|          .......||::.|::.::    ..::..|..:
Frog   380 FIRFVN---WKDKMAVEELEERL----------YRHGKKHVTWSPDSSIKR----HQERTDESSE 427

  Fly   399 FKTAKKASIKQDMNAAPFKDFNSPQKAPIEQDMDETRS--------------RDYKTSQKTPIQQ 449
            .:..|:|:.:|     |.|..:.    ...:.:|..|:              ..|:......|:.
Frog   428 TECPKEAASEQ-----PLKILSK----VANEALDNYRTTSSQISAVVGGPGFHSYRPCGLPSIRT 483

  Fly   450 DM---------DDTRVGDVINPEFSTLCG-------LWPSDFKALRSKDEIERIFKDI---VSKE 495
            |:         |.|..||. :..|..||.       ::..:|...|||.||.:|..:|   :|.|
Frog   484 DITPPHFRRLTDKTNYGDE-SSVFGLLCPSVFSQHMIYEDEFFKSRSKKEIAQILNNIGVFISGE 547

  Fly   496 DFQTIWLSLMDEQ-KDQNEMASVAQFRAQMK 525
            ||:.:|.....|. |.:..:.|:......||
Frog   548 DFEELWQKAAKEHPKGEVSVESIRYVLDAMK 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33490	NP_996047.1	None
efhb	NP_001188396.1	EF-hand_7	324..384	CDD:290234	8/60 (13%)
efhb	NP_001188396.1	EFh	324..384	CDD:238008	8/60 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1016066at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12086
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020