DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG33288 and HERC2

DIOPT Version :9

Sequence 1:NP_996136.2 Gene:CG33288 / 2768968 FlyBaseID:FBgn0053288 Length:1115 Species:Drosophila melanogaster
Sequence 2:NP_004658.3 Gene:HERC2 / 8924 HGNCID:4868 Length:4834 Species:Homo sapiens


Alignment Length:881 Identity:167/881 - (18%)
Similarity:274/881 - (31%) Gaps:301/881 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 ISGPNQS--AVICESGRLFVWGENHYGQLGIGGHGGASGKKGGGSHNGNGDIVTKPTCVKALKTL 98
            ::|.::|  ||..| |:::..||...|:||:|...|.               |..|..:.||.:.
Human  2997 VAGGSKSLFAVTVE-GKVYACGEATNGRLGLGISSGT---------------VPIPRQITALSSY 3045

  Fly    99 GLKICDVAFGNHWAVMLTHSNEIFFTGRNIFPEDTHVAQHFTSAQVDQQPCAIIRKPFRLEEFDD 163
            .:|...|..|...|..||...::|..|..    |.....||:....|        ||..:|..  
Human  3046 VVKKVAVHSGGRHATALTVDGKVFSWGEG----DDGKLGHFSRMNCD--------KPRLIEAL-- 3096

  Fly   164 YLSKNEETDNFMTVQAGKEHFAVLTTTGRLI--GCGSNAQLQLGELEADYDGHPVEIRLDAPVQQ 226
                  :|.....:..|..|.|.||::|.|.  |.|...:|..|:.........|::.|...|.|
Human  3097 ------KTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQ 3155

  Fly   227 FTCGPE--STLVLTATGNLFLTGHLNEFVFPRFTELQK------NLPPTEAIIFMHISKTSEVYI 283
            ..||..  .||.||..|.:|..|..:      |.:|.:      |:|                  
Human  3156 VACGSRDAQTLALTDEGLVFSWGDGD------FGKLGRGGSEGCNIP------------------ 3196

  Fly   284 VTNAGSIYRSFESLRNKSLVFQRFYDYDCEENGPIWKLLKGFSFYAVLSKANKFFT----TFSES 344
                    ::.|.|..:.:.     ..:|           |..|...|:|:...:|    .:...
Human  3197 --------QNIERLNGQGVC-----QIEC-----------GAQFSLALTKSGVVWTWGKGDYFRL 3237

  Fly   345 GH----HLKTFREISKFKNLRLLDIAVGDQHVLV-----------------QGIPRSSMSSASVN 388
            ||    |::..:.:...:..:::.:|||..|.|.                 ||           |
Human  3238 GHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQG-----------N 3291

  Fly   389 GSAEPNRYVNRSFVLQPTDANGNKEDTRTHSGRSLIKQEGMEETEDLSMSTTVGELAAAAGAGTA 453
            |:...||        :||...|               .||.:.|.            .|.|:..:
Human  3292 GTTTVNR--------KPTLVQG---------------LEGQKITR------------VACGSSHS 3321

  Fly   454 AAMEAVKHLINGEKPEEKSDLTRYQDLNANIESADIIPKEHKEAKGSDEIGPNSNISEKEEDNQI 518
            .|...|                   |:........::.:..::..|:..:|..|:.......|:|
Human  3322 VAWTTV-------------------DVATPSVHEPVLFQTARDPLGASYLGVPSDADSSAASNKI 3367

  Fly   519 ADRVTPGNKNESAADQEKSVHSPNTAATSEAIKTNDGYKEMKPSATIESPVITA-------DTKE 576
                       |.|...|    ||..:.::.:.:.||....:.:.   |.::||       |...
Human  3368 -----------SGASNSK----PNRPSLAKILLSLDGNLAKQQAL---SHILTALQIMYARDAVV 3414

  Fly   577 SSLKP--IVSPVKTKRSPAKTIESSIKSSSSPVKPTESMQKLPTPPTHTPTPPNSPTESLRSNKS 639
            .:|.|  :::||:.. |.:....|...:.:||:...|.|..:......:|.|.....|.:.|.  
Human  3415 GALMPAAMIAPVECP-SFSSAAPSDASAMASPMNGEECMLAVDIEDRLSPNPWQEKREIVSSE-- 3476

  Fly   640 AHDMELVDPKPKVPGSQETLLRPRTPYPESSNSST--PQTIKKTPIRNFSYESAMDHDHLERTSP 702
                :.|.|....|.:.....||..|..:...:::  .:|:.||.                    
Human  3477 ----DAVTPSAVTPSAPSASARPFIPVTDDLGAASIIAETMTKTK-------------------- 3517

  Fly   703 ELVSSLDTVEEVPTAKIHVNTPTPPTEDDEHLAVEITTTKDSTDSSKVINEIRFI------NDGV 761
                  :.||....|.    .|.|...|      |.|:...:.|:..|::.::..      :.|.
Human  3518 ------EDVESQNKAA----GPEPQALD------EFTSLLIADDTRVVVDLLKLSVCSRAGDRGR 3566

  Fly   762 DVTSRV-------EEQMPDTPLESSVEDLESDGEQKMQRGEEQVDKIVTSSEEAVSKVGEDAIDV 819
            ||.|.|       ..|:.|..||..|.:||.               :.|.|:             
Human  3567 DVLSAVLSGMGTAYPQVADMLLELCVTELED---------------VATDSQ------------- 3603

  Fly   820 MDSTRNSIQTAVKNAANGARDAMEAVGERMATGARG 855
              |.|.|.|..|..:::...|.....|.....||.|
Human  3604 --SGRLSSQPVVVESSHPYTDDTSTSGTVKIPGAEG 3637

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG33288NP_996136.2 ATS1 5..>260 CDD:227511 58/229 (25%)
HERC2NP_004658.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 50..88
RCC1 1-1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21 415..461
RCC1 1-2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21 462..512
RCC1 1-3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21 513..568
RCC1 514..566 CDD:278826
RCC1 1-4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21 569..620
RCC1 569..620 CDD:278826
RCC1 1-5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21 623..674
RCC1 623..672 CDD:278826
RCC1 1-6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21 675..726
RCC1 675..724 CDD:278826
RCC1 1-7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21 728..778
Cyt-b5 1209..1282 CDD:278597
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1555..1575
MIB_HERC2 1870..1929 CDD:284184
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1933..1958
UBA_HERC2 2460..2507 CDD:270585
Cul7 2554..2631 CDD:288381
ZZ_HERC2 2706..2750 CDD:239084
APC10-HERC2 2765..2910 CDD:176485
RCC1 2-1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21 2958..3009 4/11 (36%)
RCC1 2960..3007 CDD:278826 2/9 (22%)
RCC1 2-2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21 3010..3064 18/69 (26%)
RCC1 3010..3062 CDD:278826 17/67 (25%)
RCC1 2-3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21 3065..3116 14/70 (20%)
RCC1 3065..3114 CDD:278826 13/68 (19%)
RCC1 3117..3168 CDD:278826 14/50 (28%)
RCC1 2-4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21 3118..3168 14/49 (29%)
RCC1 2-5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21 3171..3222 13/98 (13%)
RCC1 3171..3220 CDD:278826 12/96 (13%)
RCC1 3223..3272 CDD:278826 9/48 (19%)
RCC1 2-6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21 3224..3274 9/49 (18%)
RCC1 2-7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21 3275..3326 15/96 (16%)
RCC1 3275..3324 CDD:278826 14/94 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3602..3629 7/41 (17%)
RCC1 3-1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21 3951..4002
RCC1 3-2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21 4004..4056
RCC1_2 4039..4069 CDD:290274
RCC1 4057..4106 CDD:278826
RCC1 3-3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21 4058..4108
RCC1 3-4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21 4110..4162
RCC1 4110..4160 CDD:278826
RCC1 4163..4212 CDD:278826
RCC1 3-5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21 4164..4214
RCC1 4215..4263 CDD:278826
RCC1 3-6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21 4216..4266
RCC1 4267..4316 CDD:278826
RCC1 3-7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21 4268..4318
HECTc 4421..4792 CDD:238033
HECTc 4464..4790 CDD:214523
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4804..4834
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5184
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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