DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33288 and EEA1

DIOPT Version :9

Sequence 1:	NP_996136.2	Gene:	CG33288 / 2768968	FlyBaseID:	FBgn0053288	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	XP_011537116.1	Gene:	EEA1 / 8411	HGNCID:	3185	Length:	1453	Species:	Homo sapiens

Alignment Length:	1036	Identity:	192/1036 - (18%)
Similarity:	348/1036 - (33%)	Gaps:	295/1036 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   290 IYRSFESLRNKSLVFQRFYDYDCEENGPIWKLLK--GFSFYAVLSKANKFFTTFSESGHHLKTFR 352
            :.|..|.|..::.|.|   |...|       ||:  |....|||.|......|..:: ..|:..|
Human   235 VTRLTEELNKEATVIQ---DLKTE-------LLQRPGIEDVAVLKKELVQVQTLMDN-MTLERER 288

  Fly   353 EISKFKN------------------LRLLDIAVGDQHVLVQGIPRSSMSSASVNGSAEPNRYVNR 399
            |..|.|:                  || .::|.|.|.|.|. :.......:|||...:.|:.:..
Human   289 ESEKLKDECKKLQSQYASSEATISQLR-SELAKGPQEVAVY-VQELQKLKSSVNELTQKNQTLTE 351

  Fly   400 SFVLQPTDANGNKEDTRTHSGRSLIKQ--EGMEETEDLSMSTTVGELAAAAGAGTAAAMEAVKHL 462
            :.:.:..|....:|   .|:..|:.|:  :.....:||........|:|:         |...|.
Human   352 NLLKKEQDYTKLEE---KHNEESVSKKNIQATLHQKDLDCQQLQSRLSAS---------ETSLHR 404

  Fly   463 INGEKPEE-------KSDL----TRYQDLNANIESADIIPKEHKEAKG---SDEIGP-NSNISEK 512
            |:.|..|:       |.:|    |:||.|.|..:... ..:|.||..|   ..||.. :|.:.|.
Human   405 IHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQ-QQREEKEQHGLQLQSEINQLHSKLLET 468

  Fly   513 E-----------EDNQIADRVTPGNKNESAAD------------QEKSVHSPNTAATSEAIKTND 554
            |           |..|::..... :|.:..||            :||..:|  |....:..||..
Human   469 ERQLGEAHGRLKEQRQLSSEKLM-DKEQQVADLQLKLSRLEEQLKEKVTNS--TELQHQLDKTKQ 530

  Fly   555 GYKEMKPSATIESPVITADTKESSLKPIVSPVKTKRSPAKTIESSIKSSSSPVK----------- 608
            .::|.:  |..:|........::.|:.::..:..|....:.:|:.::.|...:.
Human   531 QHQEQQ--ALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYA 593

  Fly   609 -------PTESMQKLPTPPTHTPTPPNSPTESLRSNKSAHDM-------ELVDPKPKVPGSQETL 659
                   .|..:.:|..............||.|::...:|..       ::.:.|..:..:|:.:
Human   594 KIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRV 658

  Fly   660 LRPRTPYPESSNSSTPQTIKKTPIRNFSYESAMDHDHLERTSPELVSSLDTVEEVPTAKI--HVN 722
            |...|    |.|....|.       |.|.|.....|...:...||:.|.:..:....|.:  |::
Human   659 LSLET----SVNELNSQL-------NESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLD 712

  Fly   723 TPTPPTEDDEHLAVEITTTKDST-----DSSKVINEI---------RFIN--------------- 758
            |.....:|.:....:|||..|..     |..:..:::         ::::
Human   713 TAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKL 777

  Fly   759 --DGVDVTSRVEEQMPD--------TPLESSVEDLESDGE-------------QKMQRGEEQVDK 800
              |.::|.:..|:.:.|        |.||....:|....|             ||.....|.:.:
Human   778 EADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQ 842

  Fly   801 IVTSSEEAVSKVGEDAIDVMDSTR-------NSIQTAVKNAANGARDAMEAVGERMATGARGAVD 858
            .:|..||....:.:|...:...|:       |.|||.|..... .:...||:...::| .:..:.
Human   843 KLTKQEEEKKILKQDFETLSQETKIQHEELNNRIQTTVTELQK-VKMEKEALMTELST-VKDKLS 905

  Fly   859 TVGGAV----------GAAGKGA------------HRL--------------------ASDAMHA 881
            .|..::          ...||.|            |:|                    ..:|.|.
Human   906 KVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQ 970

  Fly   882 VEQVGSSAMHAVEQAGS----------------NAVKAASETKDSMGRAMD-----SVTSK---- 921
            ::...:|....:.||.:                |.:|.:||.|.....|:.     :|..|
Human   971 LKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELE 1035

  Fly   922 ---------ISTEVLGAKENISSL-FQIKAAREADPQTTPCSTPRGEDDLSFKEGAPKTTTTLGS 976
                     .:.|:...||.||.| ...:.::|...|.......|..:.|:.::........|..
Human  1036 NKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSL 1100

  Fly   977 NEEDERTTASVNSNHNSAGHGNGNGNIFEPSTTFEDPLDAVVERSKKAMQDDIRAMQLRANSHIQ 1041
            .:||      :.||.|..|:.|   .:.:...|.:..|:....:.::.:|:..:|:|     .||
Human  1101 AQED------LISNRNQIGNQN---KLIQELKTAKATLEQDSAKKEQQLQERCKALQ-----DIQ 1151

  Fly  1042 AVAQQKEED---AKGFVKQVMDRLSCRNEKAV-RIEDELRPPAGSHNKNTNKVNSELSLTN 1098
            .....||::   .|..:.:: :.:.||.||.: ::.:||:    ||     |:.|...:||
Human  1152 KEKSLKEKELVNEKSKLAEI-EEIKCRQEKEITKLNEELK----SH-----KLESIKEITN 1202

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33288	NP_996136.2	ATS1	5..>260	CDD:227511
EEA1	XP_011537116.1	Myosin_tail_1	308..1382	CDD:279860	172/952 (18%)
		DUF342	<425..519	CDD:302792	22/97 (23%)
		FYVE_EEA1	1389..1451	CDD:277269
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900