Protein Alignment CG33288 and RPGR

DIOPT Version :9

• Sequence 1: NP_996136.2
• Gene: CG33288 / 2768968
• FlyBaseID: FBgn0053288
• Length: 1115
• Species: Drosophila melanogaster
• Sequence 2: NP_001030025.1
• Gene: RPGR / 6103
• HGNCID: 10295
• Length: 1152
• Species: Homo sapiens
• Alignment Length: 1109
• Identity: 224/1109 - (20%)
• Similarity: 366/1109 - (33%)
• Gaps: 296/1109 - (26%)

  Fly     3 IPASGAIFTLGKSHLAENTQSYFYIKNDPVKRLISGPNQSAVICESGRLFVWGENHYGQLGIGGH 67
            :|.|||:||.|||..|||....|:.|||....|..|...|||:..:.:|:::|.|::||||:|..
Human     8 MPDSGAVFTFGKSKFAENNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSK 72

  Fly    68 GGASGKKGGGSHNGNGDIVTKPTCVKALKTLGLKICDVAFGNHWAVMLTHSNEIFFTG------- 125
            ..                ::|||||||||...:|:  .|.|.:..::.|....::.||
Human    73 SA----------------ISKPTCVKALKPEKVKL--AACGRNHTLVSTEGGNVYATGGNNEGQL 119

  Fly   126 -------RNIFPEDTHVAQHFTSAQVDQQPCAIIRKPFRLEEFDDYLSKNEETDNFMTVQAGKEH 183
                   ||.|    ||...|||....:|                             :.||...
Human   120 GLGDTEERNTF----HVISFFTSEHKIKQ-----------------------------LSAGSNT 151

  Fly   184 FAVLTTTGRLIGCGSNAQLQLGELEADYDGHPVEIRLDAPVQQFTCGPESTLVLTATGNLFLTG- 247
            .|.||..|||...|.|::.|:|.........|.::.:..||...:||...:..:|..|.|::.|
Human   152 SAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGE 216

  Fly   248 -HLNEFVFP-------RFTELQKNLPPTEAIIFMHISKTSEVYIVTNAGSIY------------- 291
             ...:...|       |..:|...:|  |.:|  .::...|..:|....::|
Human   217 PENGKLGLPNQLLGNHRTPQLVSEIP--EKVI--QVACGGEHTVVLTENAVYTFGLGQFGQLGLG 277

  Fly   292 ---------RSFESLRNKSLVFQRFYDYDCEENGPIWKLLKGFSFYAVLSKANKFFTTFSESGHH 347
                     :..|::|::::.:     ..|.||           ..|:::.....: ||.: |.|
Human   278 TFLFETSEPKVIENIRDQTISY-----ISCGEN-----------HTALITDIGLMY-TFGD-GRH 324

  Fly   348 LKTFREISKFKN----------LRLLD--IAVGDQHVLVQGIPRSSMSSA----SVNGSA----- 391
            .|....:..|.|          ||.:.  :|.|..|::|...|...::..    .:|.:.
Human   325 GKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVVFAAPHRGVAKEIEFDEINDTCLSVAT 389

  Fly   392 -EPNRYVNRSFVLQPTDANGNKEDTRTHSGRSLIKQEGMEETEDLSMSTTVGELAAAAGAGTAAA 455
             .|...:....|||           ||.|.| :.::|.....:..||..|:..:....|......
Human   390 FLPYSSLTSGNVLQ-----------RTLSAR-MRRRERERSPDSFSMRRTLPPIEGTLGLSACFL 442

  Fly   456 MEAVKHLINGEKPEEKSDLTRYQDLNANIESADIIPKEHKEAKGSDEIGPNSNISEKEEDNQIAD 520
            ..:|....: |:..::|.|:. |||....|...::.:..|||    ||..:|.:....|...|.:
Human   443 PNSVFPRCS-ERNLQESVLSE-QDLMQPEEPDYLLDEMTKEA----EIDNSSTVESLGETTDILN 501

  Fly   521 --RVTPGNKNE-----SAADQEKSVHSPNTAATSEAIKTNDG---YKEM---------------- 559
              .:...|.||     |...::|...:........|:..||.   |:||
Human   502 MTHIMSLNSNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQG 566

  Fly   560 ----KPSATIES----PVITADTKESSLKPIVSPVKTKRSPAKTIESSIKSSSSPVKPTESMQKL 616
                :|:.|||:    .|...:.||.:.....:.::.:...|.  |.::|......:.||
Human   567 IFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEAN--EENVKVHGGRKEKTE----- 624

  Fly   617 PTPPTHTPTPPNSPTESLRSNKSAHDMELVDPKPKVPGSQETLLRPRTPYPESSNSSTPQTIKKT 681
                             :.|:......|:.:.|.|..|..|       ..||.....|.:
Human   625 -----------------ILSDDLTDKAEVSEGKAKSVGEAE-------DGPEGRGDGTCE----- 660

  Fly   682 PIRNFSYESAMDHDHL---ERTSPELVSSLDTVEEVPTAKIHVNTPTPPTEDDEHLAVEITTTKD 743
                   |.:...:|.   ||...|.......:|.             |.|.::.||.:....|
Human   661 -------EGSSGAEHWQDEEREKGEKDKGRGEMER-------------PGEGEKELAEKEEWKK- 704

  Fly   744 STDSSKVINEIRFINDGVDVTSRVEEQ----MPDTPLESSVEDLESDGEQKMQRGEEQVDKIVTS 804
                          .||.:...:..||    ..:..:|...|:...:||::....||:.:|....
Human   705 --------------RDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEG 755

  Fly   805 SEEAVSKVGEDAIDVMDSTRNSIQTAVKNAANGARDAMEAVGERMATGARGAVDTVGGAVGAA-- 867
            .||...:..|...:..:..|...:.|.|. ..|..:..:..||...|..||.....||.|...
Human   756 KEEGEGEEVEGEREKEEGERKKEERAGKE-EKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEV 819

  Fly   868 --GKGAHRLASDAMHAVEQVGSSAMHAVEQAGSNAVKAASETKDSMGRAMDSVTSKISTEVLGAK 930
              |||......:.....|:.|...    |:.|....:......:..|...:........|..|.:
Human   820 EEGKGEREEEEEEGEGEEEEGEGE----EEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEE 880

  Fly   931 ENISSLFQIKAAREADPQTTPCSTPRGEDDLSFKEGAPKTTTTLGSNEEDERTTASVNSNHNSAG 995
            |            |.:.:........||::....||..:     |..|.:|.............|
Human   881 E------------EGEGEGEEEGEGEGEEEEGEGEGEEE-----GEGEGEEEEGEGKGEEEGEEG 928

  Fly   996 HGNG 999
            .|.|
Human   929 EGEG 932

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33288	NP_996136.2	ATS1	5..>260	CDD:227511	75/277 (27%)
RPGR	NP_001030025.1	RCC1	<38..312	CDD:332518	73/344 (21%)
		RCC1	314..360	CDD:306840	11/47 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	43	1.000	Domainoid score	I12392
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.000