DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33288 and herc2

DIOPT Version :9

Sequence 1:	NP_996136.2	Gene:	CG33288 / 2768968	FlyBaseID:	FBgn0053288	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	XP_021332870.1	Gene:	herc2 / 558479	ZFINID:	ZDB-GENE-070718-6	Length:	4831	Species:	Danio rerio

Alignment Length:	877	Identity:	165/877 - (18%)
Similarity:	269/877 - (30%)	Gaps:	307/877 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 KRLISGPNQSAVICESGRLFVWGENHYGQLGIGGHGGASGKK------------------GGGSH 79
            ::.:||...:|.|  ..::||||.|...||     ||..|.|                  .|||.
Zfish  2939 RKRLSGLESAATI--RTKVFVWGLNDKDQL-----GGLKGSKIKVPSFSETLSALNVVQVAGGSK 2996

  Fly    80 ------------------NG------NGDIVTKPTCVKALKTLGLKICDVAFGNHWAVMLTHSNE 120
                              ||      :...:..|..:.||....:|...|..|...|:.||...:
Zfish  2997 SLFAVTAEGKVYACGEATNGRLGLGLSSGTIPIPRQISALSNYVVKKVAVHSGGRHAMALTVDGK 3061

  Fly   121 IFFTGRNIFPEDTHVAQHFTSAQVDQQPCAIIRKPFRLEEFDDYLSKNEETDNFMTVQAGKEHFA 185
            :|..|..    |.....||:....|        ||..:|..        :|.....:..|..|.|
Zfish  3062 VFSWGEG----DDGKLGHFSRMNCD--------KPRLIEAL--------KTKRIRDIACGSSHSA 3106

  Fly   186 VLTTTGRLI--GCGSNAQLQLGELEADYDGHPVEIRLDAPVQQFTCGPE--STLVLTATGNLFLT 246
            .:|::|.|.  |.|...:|..|:.........|::.|...|.|..||..  .||.||..|.:|..
Zfish  3107 AITSSGELYSWGLGEYGRLGHGDNTTQLRPKLVKVLLGHRVVQVACGSRDAQTLALTDEGMVFSW 3171

  Fly   247 GHLNEFVFPRFTELQK------NLPPTEAIIFMHISKTSEVYIVTNAGSIYRSFESLRNKSLVFQ 305
            |..:      |.:|.:      |:|                          ::.|.|..:.:.
Zfish  3172 GDGD------FGKLGRGGSEGCNIP--------------------------QNIERLNGQGVC-- 3202

  Fly   306 RFYDYDCEENGPIWKLLKGFSFYAVLSKANKFFT----TFSESGH----HLKTFREISKFKNLRL 362
               ..:|           |..|...|:|:...:|    .:...||    |::..:.:...:..::
Zfish  3203 ---QIEC-----------GAQFSLALTKSGVVWTWGKGDYFRLGHGTDVHVRKPQMVEGLRGKKI 3253

  Fly   363 LDIAVGDQHVLV-----------------QGIPRSSMSSASVNGSAEPNRYVNRSFVLQPTDANG 410
            :.:|||..|.|.                 ||           ||:...||        :||...|
Zfish  3254 VHVAVGALHCLAVTETGQVFAWGDNDHGQQG-----------NGTTTVNR--------KPTLVQG 3299

  Fly   411 NKEDTRTHSGRSLIKQEGMEETEDLSMSTTVGELAAAAGAGTAAAMEAVKHLINGEKPEEKSDLT 475
                           .||.:.|.            .|.|:..:.|...|
Zfish  3300 ---------------LEGQKITR------------VACGSSHSVAWTTV---------------- 3321

  Fly   476 RYQDLNANIESADIIPKEHKEAKGSDEIGPNSNISEKEEDNQIADRVTPGNKNESAADQEKSVHS 540
               |:........::.:..:::.|:..:|..|     :.|..:......|..|.          .
Zfish  3322 ---DVTTPSVHEPVLFQTARDSLGASYLGVPS-----DSDPSLLSNKLNGVNNV----------K 3368

  Fly   541 PNTAATSEAIKTNDGYKEMKPSATIESPVITADTKESSLKPIVSPVKTKRSPAKTIESSIKSSSS 605
            ||..:.::.:.:.||..                .|:.:|..::|.::...:....:.:.:.|...
Zfish  3369 PNRPSLAKILLSLDGNL----------------AKQQALSHVLSSLQIMYARDAVVGALMPSCMM 3417

  Fly   606 PVK-PTESMQKLPTPPTHTPTPPNSPTESLRSNKSAHDMELVDPKPKVP---GSQETLLRPRTPY 666
            |:: |:.|    |.||:.. :..:||.|:......:...|.|.|.|.:.   |...|.....||
Zfish  3418 PLECPSSS----PVPPSDC-SSASSPCEAEGPALPSESEERVSPHPWMDSKRGEVTTSEDATTP- 3476

  Fly   667 PESSNSSTPQTIKKTPIRNFSYESAMDHDHLERTSPELVSSLDTVEEVPTAKIHVNTPTPPTEDD 731
               |::.||.|...:. |.|                     :...::...|.|...|.|...||.
Zfish  3477 ---SSAVTPSTASASS-RPF---------------------IPVTDDPGAASIIAETMTKTKEDS 3516

  Fly   732 EHLAV----------EITT------TKDSTDSSKVINEIRFINDGVDVTSRVEE-------QMPD 773
            |:.:.          |.|:      |:...|..|:...:|..:.|.:|.|.|..       |:.|
Zfish  3517 ENQSKAVGPEPQYLDEFTSLLIPDDTRVMVDLLKLAVSLRSGDKGKEVLSAVLSGMGTACPQVAD 3581

  Fly   774 TPLESSVEDLESDGEQKMQRGEEQVDKIVTSS 805
            ..||..|.:|| |.....|.|......:|..|
Zfish  3582 MLLELCVTELE-DVATDCQSGRLSSQPVVVES 3612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33288	NP_996136.2	ATS1	5..>260	CDD:227511	63/272 (23%)
herc2	XP_021332870.1	RCC1	<483..772	CDD:332518
		Cyt-b5	1204..1276	CDD:306642
		MIB_HERC2	1862..1920	CDD:310955
		UBA_HERC2	2453..2499	CDD:270585
		Cul7	2548..2625	CDD:314424
		ZZ_HERC2	2700..2744	CDD:239084
		APC10-HERC2	2759..2902	CDD:176485
		RCC1	2946..3316	CDD:332518	94/490 (19%)
		RCC1	4020..4325	CDD:332518
		HECTc	4418..4789	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900