DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33288 and Als2

DIOPT Version :9

Sequence 1:	NP_996136.2	Gene:	CG33288 / 2768968	FlyBaseID:	FBgn0053288	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	NP_649347.1	Gene:	Als2 / 40410	FlyBaseID:	FBgn0037116	Length:	1486	Species:	Drosophila melanogaster

Alignment Length:	1315	Identity:	251/1315 - (19%)
Similarity:	405/1315 - (30%)	Gaps:	472/1315 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ASGAIFTLGKSHLAENTQSYFYIKNDPVKRLISGPNQSAVICES-GRLFVWGENHYGQLGIGGHG 68
            |:|:...:|..| |..|..:     ||::....|.....|.|.: |.:||
  Fly   109 ATGSGRDVGHPH-AWQTLGF-----DPLELHAEGVRIRRVCCSAQGVVFV--------------- 152

  Fly    69 GASGKKGGGSHNGNGDIVTKPTCVKALKT-----------LGLKICDVAFGNHWAVMLT------ 116
            |||           |:.....:|.:..|.           .|.::.|:|.||...|||.
  Fly   153 GAS-----------GETYVMGSCGEVFKAEQQPRHMRLYEEGKELLDLAAGNEHFVMLVAPYNLA 206

  Fly   117 -HSNEIFFTGRNIFPEDTHVAQHFTSAQVDQQPCAI----------------------------- 151
             .:.::........|||...:....|:...::..|.
  Fly   207 DDALQLSVASAKEEPEDERASVKSISSGHSERSVAANTRHLLHQGYALLHTQLFTFGASNNGLLG 271

  Fly   152 ----IRKP--FRLEEFDDYLSKNEETDNFMTVQAGKEHFAVLTTTGRLIGCGSNAQLQLGELEAD 210
                ||:.  .||::.|..        ...::.||.||....|..|||...|.|...||||   |
  Fly   272 SGDHIRRANVMRLQKLDSM--------GVCSIAAGLEHTVARTLDGRLYHWGLNNHSQLGE---D 325

  Fly   211 YDGHPVEIRLD-----APVQQ-----FTCGPESTLVLTATGNLFLTGHLNEFVFPRFTELQKNLP 265
            ... |:||.:.     .|::|     .|||...||:|.|:|.:    |..: ..|....||::..
  Fly   326 VSS-PMEITITENTAALPIEQNSALEATCGDYHTLLLNASGQI----HSLQ-PAPPMRHLQQSST 384

  Fly   266 PTEAIIFMHISKT--SEVYIVTNAGSIYRSFESLRNKSLVFQRFYDYDCEENGPIWKLLKGFSFY 328
            ..:.::.:.:...  .::.::..:|..     :|:|:. .|||.|.|                :.
  Fly   385 YAQTLLQLQLGAAWPRQLRLLMCSGGY-----TLQNQR-QFQRQYHY----------------YL 427

  Fly   329 AVLSKANKFFTTFSESGHHLKTFREISKFKNL-----------RLLDIAVGDQHVLVQGIPRSSM 382
            :.|....:......::...|:.::..|..:.|           |:|.:.|...|.| :|..|:..
  Fly   428 SHLQSQLQLLLKHRQAVQTLEIWQRQSALEPLSALGPLLINWERILCLLVATLHSL-EGFYRADF 491

  Fly   383 SSASVNGSAEPNRYVNRSFVLQPTDANGNKEDTRTHSGRSLIKQEGMEETEDLSMSTTVG--ELA 445
                                :||.|               |:.....:|..||....|..  ::.
  Fly   492 --------------------VQPAD---------------LLFICHYKEYIDLFDGYTKAYCDVF 521

  Fly   446 AAAGAGTAAAMEAVKHLINGEKP----EEKSDLTR--------YQDLNANIESADIIPK------ 492
            :..|.|     |||..:.....|    .|:|.:||        ||   ..::..:::.:
  Fly   522 SVNGFG-----EAVVAITGLSSPLAELNEESYVTRLFQQPFSIYQ---LFVQFMELLVRTQSEYG 578

  Fly   493 EHKEAKGSDEIGPNSNISEKEEDNQIADRVTPGNKN---------------ESAADQEKSVHSPN 542
            ||:.|  ..|...:|.||::...| ..|..:..::|               .||....|.|.|..
  Fly   579 EHRVA--WSEFARHSCISQELAVN-TKDFWSSNDRNPRIVQFRGRHRRVILTSALVPLKLVTSGI 640

  Fly   543 TAATSEAIKTNDGYKEMKPSATIESPVIT--ADTKESSLKPIVSP-----VKTKRSPAKTI---- 596
            :.:::..|..:|...::..::....|:.|  ..|:..||: :.:|     |.|:....:.:
  Fly   641 SRSSNSFILFSDFLCQVSGNSLYSYPLTTLWVWTEGDSLR-LTTPEKSFLVSTRSQEMRKVWLDQ 704

  Fly   597 -ESSIKSSSSPVKPTESMQKLPTPPTHTPTPPNSPTESLRSNKSAHDMELVDPK---PKVPGS-Q 656
             :|||.:|..                   .|..||..|.||  :.::.....||   .|..|: :
  Fly   705 LQSSIIASLG-------------------KPLGSPVPSYRS--TGYEFSREHPKFSRVKACGTWR 748

  Fly   657 ETLLRPR--TPYPESSNSSTPQTIKKTPIRNFSYESAMDHDHLERTSPELVSSLDTVEEVPTAKI 719
            :.:|...  ..||:.|                .|...:.|..:|.....:         :||..:
  Fly   749 KGVLHGNCYLEYPDGS----------------VYCGELQHGIIEGFGKMV---------IPTTGL 788

  Fly   720 HVNTPTPPTEDDEHLAVEITTTKDSTDSSKVINEIRFINDGVDVTSRVEEQMPDTPLESSVED-- 782
            :|..                           ....||...||     .|....|:| ||.|.:
  Fly   789 YVGN---------------------------FKGGRFHGHGV-----YEMHCKDSP-ESEVYEGN 820

  Fly   783 -----LESDGEQKMQR----GEEQVDKIVTSSEEAVSKVG--EDAID-------VMDSTRNSIQT 829
                 ....|..:..|    ||.|.:        |.|..|  ||.:.       ..|:.|:.|.:
  Fly   821 FCEGLFHGHGVMRNNRYIYVGEYQAN--------ARSGYGVIEDLVSGDKYMGMFADNKRSGIGS 877

  Fly   830 AVKNAANGARDAMEAVGERMATGARGAVDTVGGAV----------------GAAGKGAHRLAS-D 877
            .:.|..    |..|        |:....|..|..|                |..|:|.:.:.| |
  Fly   878 CITNRG----DYFE--------GSFSGDDLTGSGVAVFENDYYYEGELTLLGPNGRGEYYMPSGD 930

  Fly   878 AMHAVEQVGSSAM------HAVEQAGSNAVKAASETKDS---------MGRAMDSVTSKISTEVL 927
            |..     ||.||      ...|..|:......|.|.|:         :.|......|.:..:|:
  Fly   931 ACG-----GSGAMGTGEFDDTCELIGNKMFGQLSGTWDTVRIQAGELVLNRRFPKYPSSLGRQVV 990

  Fly   928 GAKENISSLFQIKAAREADPQTTPCSTPRGEDDLSFKEGAPKTTTTLGSNEEDERTTA------S 986
            .......|||.   ..|:|......||.        ..|..::..||..:.:...:||      :
  Fly   991 DHNRKWRSLFN---NFESDLANCTASTS--------SSGGNQSAGTLRKSSKPTLSTAQIWNCIA 1044

  Fly   987 VNSNHNSAGHGNGNGNIFE--------PSTTFEDPLDAVVERSKKAMQDDIRAMQLRANSHIQAV 1043
            |..:...|..|...||.|.        |..| ..|| |....:..|:.    .:|..|.|.:
  Fly  1045 VYMSKQRAREGTKPGNYFNNILLSLPLPQKT-SSPL-AKARTTTSALS----KLQTEAASAL--- 1100

  Fly  1044 AQQKEEDAKGFVKQVMDRLSCRNEKAVRIEDELRPPAG----------SHNKNTNKVNSEL---- 1094
                  |..||..:.:......|.|          |.|          .||.:.:..||.|
  Fly  1101 ------DFLGFPPRRIQSQEALNSK----------PGGLQRADSLISMGHNTSRDLDNSSLASFQ 1149

  Fly  1095 ---SLTNGQAHGDQS 1106
               ||.|...:||:|
  Fly  1150 LDQSLMNSTVNGDES 1164

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33288	NP_996136.2	ATS1	5..>260	CDD:227511	68/318 (21%)
Als2	NP_649347.1	RCC1	258..304	CDD:278826	9/53 (17%)
		RCC1_2	292..321	CDD:290274	10/28 (36%)
		RCC1	308..361	CDD:278826	20/56 (36%)
		PH-like	616..715	CDD:302622	19/118 (16%)
		VPS9	1373..1479	CDD:280383
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900