DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33288 and HECTD4

DIOPT Version :9

Sequence 1:	NP_996136.2	Gene:	CG33288 / 2768968	FlyBaseID:	FBgn0053288	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	NP_001103132.4	Gene:	HECTD4 / 283450	HGNCID:	26611	Length:	4428	Species:	Homo sapiens

Alignment Length:	795	Identity:	147/795 - (18%)
Similarity:	247/795 - (31%)	Gaps:	276/795 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   366 AVGDQ-------HVLVQG--------IPRS-SMSSASVNGSAEPNRYVNRSFVLQPTDANGNKED 414
            |.|||       |.|::|        :|.: |::::.|..:..||        |..:.::.:...
Human  3253 AAGDQGRFSTYFHALMEGCLAVAEVTLPTNMSVTASGVTSATAPN--------LSDSSSSSSSSP 3309

  Fly   415 TRTHSGRSLI--------KQEGMEETEDLSMSTTVGELAAAAGAGTAAAMEAVKHLINGEKPEEK 471
            .:|....||:        |:|....:.....|.||.........|             |.|||:.
Human  3310 GQTPQSPSLLSKRKKVKMKREKASSSGKRQSSRTVDSDPTVLSIG-------------GSKPEDM 3361

  Fly   472 SDLTRYQDLNANIESADIIPKEH---KEAKG----SDEI--------GPN--------SNISEKE 513
            ....|...|        :|...|   |:.:|    ||.|        ||.        |.|....
Human  3362 LWFHRALTL--------LIILRHLTRKDPQGLGVTSDAIADACQALVGPTAHSRLLVISGIPTHL 3418

  Fly   514 EDNQIADRVTPGNKNESAADQEKSVHSP----NTAATSEAIKTNDGYKEMKPSATIESPVITADT 574
            ::..:...:...........::: ::.|    :|....:..:..||  :::|..|:..|  ..|:
Human  3419 DEGVVRGAIRKACNAHGGVFKDE-IYIPLQEEDTKKPKDKAEGGDG--KVEPEKTLAFP--GTDS 3478

  Fly   575 KESSLKPIVSPVKTKRSPAKTIESSIKSSSS--------PVKPTESMQKLPTPP----THTPTPP 627
            .|.|....::|..:..:.|.|.::||.||..        .|.|..:..:||.||    .|..:..
Human  3479 MEVSTSSSLTPAMSISASASTSQASICSSQGISQTVSDLSVDPLPAGLELPIPPGLLEPHAVSSQ 3543

  Fly   628 NSPTESLRSNKSAHDM-ELVDPKPKVP-------GSQETLLRPRTPYPESSNSSTPQTIKKTPIR 684
            .|...||.|..|...: .|.:|.....       ||..|:           .|...|.:...||:
Human  3544 ESLDISLCSTGSLGSLGSLGEPLDNAETASVSDMGSMYTV-----------TSLDNQPLAARPIK 3597

  Fly   685 NFSYESAMDHDHLERTSPEL--------VSSLDTVEEVPTAKIHVNTPTPPTEDDEHLAVEITTT 741
            .|:.........:|:....|        :||||..:|:                     :|::|.
Human  3598 GFAVVEIRSRAKIEKIRASLFNNNDLIGLSSLDGEDEL---------------------MEMSTE 3641

  Fly   742 KDSTDSSKVINEIRFINDGVDVTSRVEEQMPDTPLESSVEDLESDGEQKMQRGEEQVDKIVTSSE 806
            :..|.|  |:|:..|                ||.....:||..:|   |..:||    |:|..:.
Human  3642 EILTVS--VVNQSLF----------------DTQGSPGLEDYFND---KSIKGE----KLVPGAR 3681

  Fly   807 EAVSKVGEDAIDVMDSTRNSIQTAVKNAANGARDAMEAVGERMATGARGAVDTVGGAVGAAGKGA 871
            |.::       ::..|..:|.||.....|...|
Human  3682 EVLT-------EIFKSCAHSEQTLSLTPAKPIR-------------------------------- 3707

  Fly   872 HRLASDAMHAVEQVGSSAMHAVEQAGSNAVKAASETKDSMGRAMDSVTSKISTEVLGAKENISSL 936
               .||...:.||:.|       |...|.:...........:.::...::|..:....|......
Human  3708 ---VSDIYLSKEQINS-------QTPGNLLHLFFTNVRPPKKVLEDQLTQILRKYGVPKPKFDKS 3762

  Fly   937 FQIKAAREADP-----QTTPCSTPRGEDDLSFKEGAPKTTTTLGSNEEDERTTASVNSNHNSAGH 996
            ...||.:|..|     ...|.:.|..:|                        .|.:||...:|..
Human  3763 KYSKAGKEQHPVKVVSTKRPITKPPAKD------------------------KAVLNSVSRTALS 3803

  Fly   997 GNGNGNIFEPSTTFEDPLDAVVERSKKAMQDDIRAMQLRANSHIQAVAQQKEEDAKGFVKQVMDR 1061
            ..      :|:...:.|     |:||...:|..::...:     |.|.::|....:||.|.|:||
Human  3804 EK------KPTVKPKSP-----EKSKPDEKDPEKSPTKK-----QEVPEEKYLTLEGFHKFVIDR 3852

  Fly  1062 ------------LSC 1064
                        |||
Human  3853 ARQDIRSVWRAILSC 3867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
CG33288	NP_996136.2	ATS1	5..>260	CDD:227511
HECTD4	NP_001103132.4	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900